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1.发明申请Processes for desolvating solvates of atorvastatin hemi-calcium and atorvastatin hem-calcium essentially free of organic solvent 审中-公开溶解阿托伐他汀半钙溶剂化物和基本不含有机溶剂的阿托伐他汀离子钙的方法公开(公告)号：US20070027328A1
公开(公告)日：2007-02-01
申请号：US11542339
申请日：2006-10-02
IPC分类号： C07D207/34
CPC分类号： C07D207/416 , C07D207/34
摘要： The present invention provides processes for removing organic solvent from crystals of atorvastatin hemi-calcium containing organic solvent. In one process, the organic solvent is displaced by vapor diffusion of water in a vessel maintained at elevated humidity. In a second process, the organic solvent is removed by fluidized bed drying. The present invention further provides atorvastatin hemi-calcium containing 1% or less organic solvent, which can be obtained from atorvastatin hemi-calcium that has been crystallized from an organic solvent-containing solution by practice of the processes of the invention.
摘要翻译： 本发明提供从含有阿托伐他汀半钙的有机溶剂的结晶中除去有机溶剂的方法。 在一个过程中，有机溶剂通过在保持在高湿度下的容器中的水的蒸汽扩散而被置换。 在第二种方法中，通过流化床干燥除去有机溶剂。 本发明还提供含有1％以下的有机溶剂的阿托伐他汀半钙，其可以通过实施本发明的方法从含有机溶剂的溶液中结晶的阿托伐他汀半钙获得。
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公开(公告)号：US20060106230A1
公开(公告)日：2006-05-18
申请号：US11253770
申请日：2005-10-18
IPC分类号： C07D207/14
CPC分类号： C07D207/337 , C07D207/34
摘要： Novel processes for the preparation of amorphous atorvastatin hemi-calcium salt are provided, which involve dissolving atorvastatin hemi-calcium salt in certain organic solvents, and removing the solvent such as by spray drying, rapid vacuum evaporation, and/or thin film evaporation. Preferred embodiments of these processes for preparing amorphous atorvastatin hemi-calcium salt are reproducible, applicable on a large scale, and do not involve the use of hydrocarbons.
摘要翻译： 提供了制备无定形阿托伐他汀半钙盐的新方法，其涉及将阿托伐他汀半钙盐溶解在某些有机溶剂中，并通过喷雾干燥，快速真空蒸发和/或薄膜蒸发除去溶剂。 用于制备无定形阿托伐他汀半钙盐的这些方法的优选实施方案是可重复的，可大规模应用，并且不涉及使用烃。
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公开(公告)号：US20060020137A1
公开(公告)日：2006-01-26
申请号：US11233310
申请日：2005-09-21
IPC分类号： A61K31/401 , C07D207/00
CPC分类号： C07D405/06 , C07D207/34
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VII, VIII, IX, IXa, X, XI, XII, XIV, XVI and XVII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
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4.发明授权Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms 失效阿伐他汀半钙的晶体形式及其制备方法以及制备其他形式的新方法公开(公告)号：US07501450B2
公开(公告)日：2009-03-10
申请号：US10370897
申请日：2003-02-19
IPC分类号： A61K31/40 , C07D207/325
CPC分类号： C07D405/06 , A61K9/282 , A61K9/5021 , C07D207/34
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VII, VIII, IX, IXa, X, XI, XII, XIV, XVI and XVII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
摘要翻译： 本发明提供了指定为形式VI，VII，VIII，IX，IXa，X，XI，XII，XIV，XVI和XVII的阿托伐他汀的新形式及其制备方法以及制备阿托伐他汀I，II，IV ，V和无定形阿托伐他汀。
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公开(公告)号：US07151183B2
公开(公告)日：2006-12-19
申请号：US11192707
申请日：2005-07-29
IPC分类号： C07D207/34
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
摘要翻译： 本发明提供命名为形式VI，VIII，IX，X，XI和XII的阿托伐他汀的新形式及其制备方法以及制备阿托伐他汀形式I，II，IV，V和无定形阿托伐他汀的方法。
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公开(公告)号：US20050261360A1
公开(公告)日：2005-11-24
申请号：US11192707
申请日：2005-07-29
IPC分类号： A61K9/28 , A61K9/50 , A61K31/40 , A61K31/401 , A61P3/06 , A61P9/00 , B01D9/02 , C07D207/34 , C07D405/06
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
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公开(公告)号：US20090215806A1
公开(公告)日：2009-08-27
申请号：US12387634
申请日：2009-05-04
IPC分类号： A61K31/505 , C07D239/42
CPC分类号： C07D239/42
摘要： Provided is rosuvastatin calcium with a low salt by product content and processes for preparing such rosuvastatin calcium.
摘要翻译： 提供的是具有低盐产品含量的瑞舒伐他汀钙和用于制备这种瑞舒伐他汀钙的方法。
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公开(公告)号：US07189861B2
公开(公告)日：2007-03-13
申请号：US11193112
申请日：2005-07-29
IPC分类号： C07D207/34
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
摘要翻译： 本发明提供命名为形式VI，VIII，IX，X，XI和XII的阿托伐他汀的新形式及其制备方法以及制备阿托伐他汀形式I，II，IV，V和无定形阿托伐他汀的方法。
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公开(公告)号：US07161012B2
公开(公告)日：2007-01-09
申请号：US11192672
申请日：2005-07-29
IPC分类号： C07D207/34
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
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10.发明授权Desolvation process for the production of atorvastatin hemi-calcium essentially free of bound organic solvent 失效用于生产阿托伐他汀半钙的脱溶剂方法基本上不含有机溶剂公开(公告)号：US07122681B2
公开(公告)日：2006-10-17
申请号：US10370424
申请日：2003-02-19
IPC分类号： C07D207/335
CPC分类号： C07D207/416 , C07D207/34
摘要： The present invention provides processes for removing organic solvent from crystals of atorvastatin hemi-calcium containing organic solvent. In one process, the organic solvent is displaced by vapor diffusion of water in a vessel maintained at elevated humidity. In a second process, the organic solvent is removed by fluidized bed drying. The present invention further provides atorvastatin hemi-calcium containing 1% or less organic solvent, which can be obtained from atorvastatin hemi-calcium that has been crystallized from an organic solvent-containing solution by practice of the processes of the invention.
摘要翻译： 本发明提供从含有阿托伐他汀半钙的有机溶剂的结晶中除去有机溶剂的方法。 在一个过程中，有机溶剂通过在保持在高湿度下的容器中的水的蒸汽扩散而被置换。 在第二种方法中，通过流化床干燥除去有机溶剂。 本发明还提供含有1％以下的有机溶剂的阿托伐他汀半钙，其可以通过实施本发明的方法从含有机溶剂的溶液中结晶的阿托伐他汀半钙获得。
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