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1.发明申请Monomethylvaline Compounds Having Phenylalanine Carboxy Modifications at the C-Terminus 有权在C-末端具有苯丙氨酸羧基修饰的单甲基缬氨酸化合物公开(公告)号：US20090111756A1
公开(公告)日：2009-04-30
申请号：US11994459
申请日：2006-07-07
CPC分类号： A61K47/48415 , A61K38/00 , A61K39/3955 , A61K47/6811 , A61K2039/505 , C07K5/0205 , C07K7/02 , C07K16/2866 , C07K2317/76 , Y02A50/40 , Y02A50/401 , Y02A50/406 , Y02A50/48
摘要： Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
摘要翻译： 制备具有C-末端苯丙氨酸羧酸当量的MeVal-Val-Dil-Dap-Phe（MMAF）的Auristatin肽类似物，并通过各种接头包括马来酰亚氨基己酰基val-cit-PAB连接到配体上。 所得配体药物偶联物在体外和体内都是活性的。
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2.发明授权Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus 有权在C末端具有苯丙氨酸羧基修饰的单甲基缬氨酸化合物公开(公告)号：US08871720B2
公开(公告)日：2014-10-28
申请号：US11994459
申请日：2006-07-07
CPC分类号： A61K47/48415 , A61K38/00 , A61K39/3955 , A61K47/6811 , A61K2039/505 , C07K5/0205 , C07K7/02 , C07K16/2866 , C07K2317/76 , Y02A50/40 , Y02A50/401 , Y02A50/406 , Y02A50/48
摘要： Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
摘要翻译： 制备具有C-末端苯丙氨酸羧酸当量的MeVal-Val-Dil-Dap-Phe（MMAF）的Auristatin肽类似物，并通过各种接头包括马来酰亚氨基己酰基val-cit-PAB连接到配体上。 所得配体药物偶联物在体外和体内都是活性的。
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公开(公告)号：US20050225105A1
公开(公告)日：2005-10-13
申请号：US10513270
申请日：2003-02-20
申请人： Damon Meyer
发明人： Damon Meyer
IPC分类号： B60B19/02
CPC分类号： B60B19/02
摘要： A self-propelled four-wheel vehicle (1) for travel on land and/or on rails includes four hubs (9) for mounting of wheels including tires (6) for travel on land, four rail wheels (7) for travel on a railway, and four coupling assemblies, for detachably connecting the rail wheels to, outwardly of, and spaced from, the hubs. A kit for converting the vehicle for travel on rails includes, for each hub (9) of the vehicle, a rail wheel adapter (25, 44) including a flange (26, 45) for fastening to a rail wheel (7) and an axle portion (24, 46) extending transverse to the flange, a vehicle wheel adapter (10, 40) including a flange (15, 41) for fastening to a hub of the land vehicle and an axle portion (21, 42) extending transverse to the flange, and a coupler (12, 13) for coupling the rail wheel adapter to the vehicle wheel adapter.
摘要翻译： 用于在陆地和/或轨道上行驶的自行车四轮车（1）包括用于安装车轮的四个轮毂（9），包括用于在陆上行驶的轮胎（6），用于在地面上行驶的四个轨道车轮（7） 铁路和四个联接组件，用于将轨道轮可拆卸地连接到毂的外部和与其间隔开。 一种用于在轨道上行驶的车辆转换的套件包括：用于车辆的每个轮毂（9）的轨道轮适配器（25,44），其包括用于紧固到轨道车轮（7）的凸缘（26,45）和 轴部分（24,46），其横向于所述凸缘延伸;车辆车轮适配器（10,40），其包括用于紧固到所述陆地车辆的轮毂的凸缘（15,41）和横向延伸的轴部分（21,42） 以及用于将轨道轮适配器联接到车轮适配器的联接器（12,13）。
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