公开(公告)号：US06214763B1

公开(公告)日：2001-04-10

申请号：US09081013

申请日：1998-05-19

Applicant: Daniel A. Dobbs ,  Koenraad P. M. Vanhessche ,  Valentin Rautens Trauch

Inventor： Daniel A. Dobbs ,  Koenraad P. M. Vanhessche ,  Valentin Rautens Trauch

IPC: B01J3100

CPC classification number: B01J31/2409 ,  B01J23/462 ,  B01J31/2295 ,  B01J31/24 ,  B01J31/2428 ,  B01J31/2452 ,  B01J31/2471 ,  B01J2531/0205 ,  B01J2531/0266 ,  B01J2531/821 ,  B01J2531/842 ,  C07C67/303 ,  C07C69/75 ,  C07C69/716

Abstract: A catalyst of Ru comprising bidentate phosphine ligands is described which is obtained by a process that comprises treating equimolar amounts of an appropriate Ru complex and a bidentate diphosphine ligand with an acid of the formula H-Anion, wherein the anion is a non-coordinating anion, said acid being used in a ratio of 1 molar equivalent per mole of Ru complex and the treatment being carried out in a non-coordinating or weakly coordinating medium, under an oxygen-free atmosphere. Said catalyst is useful for the preparation of the preferred isomer of the Hedione®, having the configuration (+)-(1R)-cis, and of many other substrates comprising highly hindered carbon-carbon double bonds.

Abstract translation: 描述了包含二齿膦配体的Ru的催化剂，其通过包括用式H阴离子的酸处理等摩尔量的合适的Ru络合物和二齿二膦配体的方法获得，其中阴离子是非配位阴离子 ，所述酸的使用比例为每摩尔Ru配合物1摩尔当量，并且在无配位或弱配位介质中，在无氧气氛下进行处理。所述催化剂可用于制备优选的 具有（+） - （1R） - 顺式构型的Hedione的异构体以及包含高度受阻碳 - 碳双键的许多其它底物。

公开(公告)号：US06455460B1

公开(公告)日：2002-09-24

申请号：US09690980

申请日：2000-10-18

Applicant: Daniel A. Dobbs ,  Koenraad P. M. Vanhessche ,  Valentin Rautenstrauch

Inventor： Daniel A. Dobbs ,  Koenraad P. M. Vanhessche ,  Valentin Rautenstrauch

IPC: B01J3100

CPC classification number: B01J31/2409 ,  B01J23/462 ,  B01J31/2295 ,  B01J31/24 ,  B01J31/2428 ,  B01J31/2452 ,  B01J31/2471 ,  B01J2531/0205 ,  B01J2531/0266 ,  B01J2531/821 ,  B01J2531/842 ,  C07C67/303 ,  C07C69/75 ,  C07C69/716

Abstract: A catalyst of ruthenium (II) comprising bidentate phosphine ligands is described which is obtained by a process that comprises treating equimolar amounts of an appropriate Ru complex and a bidentate diphosphine ligand with an acid of the formula H-Anion, wherein the anion is a non-coordinating anion, said acid being used in a ratio of 1 molar equivalent per mole of Ru complex and the treatment being carried out in a non-coordinating or weakly coordinating medium, under an oxygen-free atmosphere. Said catalyst is useful for the preparation of the preferred isomer of the Hedione®, having the configuration (+)-(1R)-cis, and of many other substrates comprising highly hindered carbon-carbon double bonds.

Abstract translation: 描述了包含二齿膦配体的钌（II）催化剂，其通过包括用式H阴离子的酸处理等摩尔量的合适的Ru配合物和二齿二膦配体的方法获得，其中阴离子是非 - - 配位阴离子，所述酸以每摩尔Ru配合物1摩尔当量的比例使用，并且处理在无配位或弱配位介质中，在无氧气氛下进行。 所述催化剂可用于制备具有（+） - （1R） - 顺式构型的Hedione的优选异构体，以及包含高度受阻碳 - 碳双键的许多其它底物。