公开(公告)号：US20060194805A1

公开(公告)日：2006-08-31

申请号：US11412526

申请日：2006-04-26

Applicant: Rajagopal Bakthavatchalam ,  Charles Blum ,  Harry Brielmann ,  Timothy Caldwell ,  Daniel Cortright ,  Kevin Hodgetts ,  John Peterson ,  Xiaozhang Zheng

Inventor： Rajagopal Bakthavatchalam ,  Charles Blum ,  Harry Brielmann ,  Timothy Caldwell ,  Daniel Cortright ,  Kevin Hodgetts ,  John Peterson ,  Xiaozhang Zheng

IPC: A61K31/525 ,  A61K31/517 ,  A61K31/519 ,  A61K31/498 ,  C07D475/10 ,  C07D487/02

CPC classification number: C04B35/632 ,  C07D215/44 ,  C07D239/94 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12 ,  C07D471/04 ,  C07D475/06

Abstract: Capsaicin receptor agonists are provided. Such compounds are ligands that may be used to modulate VR1 activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to capsaicin receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Abstract translation: 提供辣椒素受体激动剂。 这样的化合物是可用于在体内或体外调节VR1活性的配体，并且特别可用于治疗对人，驯养的伴侣动物和家畜中的辣椒素受体激活有反应的病症。 还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

公开(公告)号：US06482611B1

公开(公告)日：2002-11-19

申请号：US09667422

申请日：2000-09-21

Applicant: Daniel Cortright ,  James Krause

Inventor： Daniel Cortright ,  James Krause

IPC: C12N1512

CPC classification number: C07K14/705

Abstract: This invention provides novel human capsaicin receptors and the nucleotide sequences encoding these receptors. Also provided are vectors encoding these receptors and mammalian and non-mammalian cells expressing these vectors. Further provided are assays for identifying compounds that modulate capsaicin receptors and diagnostic assays for capsaicin receptor polymorphisms and aberrant capsaicin receptor expression.

Abstract translation: 本发明提供新的人类辣椒素受体和编码这些受体的核苷酸序列。 还提供编码这些受体的载体和表达这些载体的哺乳动物和非哺乳动物细胞。 还提供了用于鉴定调节辣椒素受体的化合物和辣椒素受体多态性和异常辣椒素受体表达的诊断测定法的测定。