公开(公告)号：US08489488B2

公开(公告)日：2013-07-16

申请号：US13324490

申请日：2011-12-13

Applicant: James Farrell ,  James Krause

Inventor： James Farrell ,  James Krause

IPC: G06Q40/00

CPC classification number: G06Q40/04

Abstract: A system mitigates market spike effects caused by conditional ordering triggering and election in an automated matching system. The system monitors trading as a result of cascading triggering of conditional orders. When an order is executed beyond a predetermined price threshold, an instrument may be flagged, allowing matching to occur only at or within the predetermined price threshold. Orders within the price threshold are matched at the price threshold against orders beyond it, dampening any instantaneous damaging effects of the price spike. The system may adjust the price threshold when market appropriate, allowing the order flow to bring the market back to whatever is the true price level. The system mitigates purely conditional order cascade driven price fluctuations, but allows the market to continuously trade in controlled price and time intervals ensuring that true market moves can still occur without price control mechanisms hindering trade matching and true price discovery.

Abstract translation: 系统减轻了在自动匹配系统中条件排序触发和选举引起的市场尖峰效应。 由于级联触发条件订单，系统监控交易。 当订单执行超过预定价格阈值时，可以标记仪器，允许仅在或在预定价格阈值内进行匹配。 在价格门槛内的订单与价格门槛相匹配，超过它的订单，抑制价格上涨的任何瞬时的破坏性影响。 该系统可以在市场适当时调整价格门槛，允许订单流量将市场恢复到真正的价格水平。 该系统减轻了纯粹的有条件订单级联驱动的价格波动，但允许市场以可控的价格和时间间隔持续交易，确保如果没有价格控制机制阻碍贸易匹配和真正的价格发现，真正的市场动向仍然可以发生。

公开(公告)号：US08103576B2

公开(公告)日：2012-01-24

申请号：US11900810

申请日：2007-09-13

Applicant: James Farrell ,  James Krause

Inventor： James Farrell ,  James Krause

IPC: G06Q40/00

CPC classification number: G06Q40/04

Abstract: A system mitigates the effects of a market spike caused by the triggering and election of conditional orders in an automated matching system. The system monitors trading that takes place as a result of the cascading triggering of conditional orders. When an order is executed beyond a predetermined price threshold, an instrument may be flagged, allowing matching to take place only at or within the predetermined price threshold. Orders within the price threshold are matched at the price threshold against orders beyond the price threshold, in order to dampen any instantaneous damaging effects of the price spike. The system may adjust the price threshold when market appropriate, allowing the order flow to bring the market back to whatever is the true price level. The system mitigates price fluctuations that are purely conditional order cascade driven, but allows the market to continuously trade in controlled price and time intervals to ensure that a true market move can still occur and not have price control mechanisms hinder trade matching and true price discovery.

Abstract translation: 系统减轻了在自动匹配系统中触发和选择条件订单引起的市场飙升的影响。 系统监视由于级联触发有条件订单而产生的交易。 当执行订单超过预定价格阈值时，可以标记工具，允许仅在或在预定价格阈值内进行匹配。 价格门槛内的订单在价格门槛上匹配超过价格门槛的订单，以抑制价格上涨的任何即时损害影响。 该系统可以在市场适当时调整价格门槛，允许订单流量将市场恢复到真正的价格水平。 该系统减轻了纯粹是有条件的级联驱动的价格波动，但允许市场以可控的价格和时间间隔持续交易，以确保真正的市场动向仍然可以发生，没有价格控制机制阻碍贸易匹配和真正的价格发现。

公开(公告)号：US20110119173A1

公开(公告)日：2011-05-19

申请号：US13010527

申请日：2011-01-20

Applicant: Ari Studnitzer ,  Seshadri Sundaram ,  Kevin Kometer ,  Sana Fathallah-Shaykh ,  James Krause

Inventor： Ari Studnitzer ,  Seshadri Sundaram ,  Kevin Kometer ,  Sana Fathallah-Shaykh ,  James Krause

IPC: G06Q40/00

CPC classification number: G06Q40/06 ,  G06Q20/102 ,  G06Q40/04

Abstract: Systems and methods are provided for processing and distributing market data. Critical data, such as data showing that a market price has changed is distributed without further delay. When the market data does not result in a change in a market price or does not meet another critical criteria, the market data is aggregated with market data for similar events and distributed when the aggregated market data passes a quantity threshold.

Abstract translation: 提供系统和方法来处理和分发市场数据。 关键数据，如显示市场价格发生变化的数据，不再拖延地分配。 当市场数据不会导致市场价格变化或不符合另一个关键标准时，市场数据与类似事件的市场数据相结合，并在汇总的市场数据通过数量阈值时分配。

公开(公告)号：US20080046356A1

公开(公告)日：2008-02-21

申请号：US11900810

申请日：2007-09-13

Applicant: James Farrell ,  James Krause

Inventor： James Farrell ,  James Krause

IPC: G06Q40/00

CPC classification number: G06Q40/04

Abstract: A system mitigates the effects of a market spike caused by the triggering and election of conditional orders in an automated matching system. The system monitors trading that takes place as a result of the cascading triggering of conditional orders. When an order is executed beyond a predetermined price threshold, an instrument may be flagged, allowing matching to take place only at or within the predetermined price threshold. Orders within the price threshold are matched at the price threshold against orders beyond the price threshold, in order to dampen any instantaneous damaging effects of the price spike. The system may adjust the price threshold when market appropriate, allowing the order flow to bring the market back to whatever is the true price level. The system mitigates price fluctuations that are purely conditional order cascade driven, but allows the market to continuously trade in controlled price and time intervals to ensure that a true market move can still occur and not have price control mechanisms hinder trade matching and true price discovery.

Abstract translation: 系统减轻了在自动匹配系统中触发和选择条件订单引起的市场飙升的影响。 系统监视由于级联触发有条件订单而产生的交易。 当执行订单超过预定价格阈值时，可以标记工具，允许仅在或在预定价格阈值内进行匹配。 价格门槛内的订单在价格门槛上匹配超过价格门槛的订单，以抑制价格上涨的任何即时损害影响。 该系统可以在市场适当时调整价格门槛，允许订单流量将市场恢复到真正的价格水平。 该系统减轻了纯粹是有条件的级联驱动的价格波动，但允许市场以可控的价格和时间间隔持续交易，以确保真正的市场动向仍然可以发生，而且没有价格控制机制阻碍贸易匹配和真正的价格发现。

公开(公告)号：US20080015183A1

公开(公告)日：2008-01-17

申请号：US11864987

申请日：2007-09-29

Applicant: Rajagopal Bakthavatchalam ,  Charles Blum ,  Harry Brielmann ,  Timothy Caldwell ,  Stephane De Lombaert ,  Kevin Hodgetts ,  Xiaozhang Zheng ,  James Krause ,  Uri Herzberg ,  Taeyoung Yoon

Inventor： Rajagopal Bakthavatchalam ,  Charles Blum ,  Harry Brielmann ,  Timothy Caldwell ,  Stephane De Lombaert ,  Kevin Hodgetts ,  Xiaozhang Zheng ,  James Krause ,  Uri Herzberg ,  Taeyoung Yoon

IPC: A61K31/517 ,  A61K31/47 ,  A61K31/519 ,  A61K31/541 ,  A61P11/14 ,  A61P17/02 ,  C07D215/58 ,  C07D237/30 ,  C07D279/12 ,  C07D471/04 ,  C07D417/12 ,  C07D413/14 ,  C07D413/10 ,  C07D401/14 ,  C07D401/10 ,  C07D239/84 ,  C07D223/04 ,  A61P25/04 ,  A61P11/16 ,  A61K31/55 ,  A61K31/5377 ,  A61K31/502

CPC classification number: C07D401/04 ,  C07D215/42 ,  C07D215/44 ,  C07D237/34 ,  C07D239/94 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D419/14 ,  C07D471/04

Abstract: Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Abstract translation: 提供了取代的喹唑啉-4-基胺类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

公开(公告)号：US06884815B1

公开(公告)日：2005-04-26

申请号：US10461311

申请日：2003-06-12

Applicant: Andrew Thurkauf ,  Xiao-shu He ,  He Zhao ,  John Peterson ,  Xiaoyan Zhang ,  Robbin Brodbeck ,  James Krause ,  George Maynard ,  Alan Hutchison

Inventor： Andrew Thurkauf ,  Xiao-shu He ,  He Zhao ,  John Peterson ,  Xiaoyan Zhang ,  Robbin Brodbeck ,  James Krause ,  George Maynard ,  Alan Hutchison

IPC: C07C233/11 ,  C07C233/22 ,  C07C233/65 ,  C07C233/66 ,  C07C233/73 ,  C07C233/78 ,  C07C235/46 ,  C07C235/48 ,  C07C235/54 ,  C07C235/60 ,  C07C235/62 ,  C07C235/66 ,  C07C237/20 ,  C07C323/62 ,  C07D207/32 ,  C07D207/327 ,  C07D213/38 ,  C07D213/82 ,  C07D215/12 ,  C07D217/04 ,  C07D217/06 ,  C07D217/14 ,  C07D217/16 ,  C07D231/12 ,  C07D233/54 ,  C07D233/68 ,  C07D235/02 ,  C07D235/10 ,  C07D235/14 ,  C07D235/18 ,  C07D317/58 ,  C07D333/24 ,  C07D333/28 ,  C07D333/54 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D471/04 ,  A61K31/415 ,  A61K31/44 ,  C07D233/02 ,  C07D401/04 ,  C07D403/02

CPC classification number: C07D207/327 ,  C07C233/11 ,  C07C233/22 ,  C07C233/65 ,  C07C233/66 ,  C07C233/73 ,  C07C233/78 ,  C07C235/46 ,  C07C235/48 ,  C07C235/54 ,  C07C235/60 ,  C07C235/62 ,  C07C235/66 ,  C07C237/20 ,  C07C323/62 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2603/18 ,  C07D213/38 ,  C07D213/82 ,  C07D215/12 ,  C07D217/04 ,  C07D217/06 ,  C07D217/14 ,  C07D217/16 ,  C07D231/12 ,  C07D233/64 ,  C07D233/68 ,  C07D235/02 ,  C07D235/14 ,  C07D235/18 ,  C07D317/58 ,  C07D333/24 ,  C07D333/28 ,  C07D333/54 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D471/04

Abstract: This invention relates to low molecular weight, non-peptidic, non-peptidomimetic, organic molecules that act as modulators of mammalian complement C5a receptors, preferably ones that act as high affinity C5a receptor ligands and also to such ligands that act as antagonists or inverse agonists of complement C5a receptors. Preferred compounds of the invention possess some or all of the following properties in that they are: 1) multi-aryl in structure, 2) heteroaryl in structure, 3) a pharmaceutically acceptable oral dose can provide a detectable in vitro effect, 4) comprise fewer than four or preferably no amide bonds, and 5) capable of inhibiting leukocyte chemotaxis at nanomolar or sub-nanomolar concentrations.This invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds in treating a variety of inflammatory and immune system disorders. Additionally, this invention relates to the use such compounds as probes for the localization of C5a receptors.

Abstract translation: 本发明涉及作为哺乳动物补体C5a受体调节剂的低分子量，非肽，非拟肽，有机分子，优选用作高亲和力C5a受体配体的调节剂，还涉及作为拮抗剂或反向激动剂的这些配体 的补体C5a受体。 本发明优选的化合物具有一些或全部以下性质，因为它们是：1）结构中的多芳基，2）结构中的杂芳基，3）药学上可接受的口服剂量可提供可检测的体外效应，4）包含 少于四个或优选不存在酰胺键，以及5）能够以纳摩尔或亚纳摩尔浓度抑制白细胞趋化性。 本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗各种炎性和免疫系统疾病中的用途。 此外，本发明涉及使用这些化合物作为C5a受体定位的探针。

公开(公告)号：US20050019869A1

公开(公告)日：2005-01-27

申请号：US10926225

申请日：2004-08-25

Applicant: Michele Kinrade ,  Robbin Brodbeck ,  James Krause

Inventor： Michele Kinrade ,  Robbin Brodbeck ,  James Krause

IPC: C12N15/09 ,  A61K45/00 ,  A61P9/00 ,  A61P25/00 ,  A61P25/22 ,  C07K14/705 ,  C07K19/00 ,  C12N5/10 ,  C12Q1/02 ,  C12R1/91 ,  C07H21/04

CPC classification number: C07K14/70571

Abstract: Novel chimeric G-protein coupled receptors are provided as isolated polypeptides, membrane preparations containing such chimeric receptors, nucleic acids encoding such chimeric receptors, and cells expressing such receptors. The chimeric receptors are NPY5 receptors with most or all of either one or both of the third cytoplasmic loop domain or the C-terminal intracellular domain of NPY5 replaced with the corresponding region(s) of another NPY receptor, preferably an NPY1 receptor.

公开(公告)号：US06482611B1

公开(公告)日：2002-11-19

申请号：US09667422

申请日：2000-09-21

Applicant: Daniel Cortright ,  James Krause

Inventor： Daniel Cortright ,  James Krause

IPC: C12N1512

CPC classification number: C07K14/705

Abstract: This invention provides novel human capsaicin receptors and the nucleotide sequences encoding these receptors. Also provided are vectors encoding these receptors and mammalian and non-mammalian cells expressing these vectors. Further provided are assays for identifying compounds that modulate capsaicin receptors and diagnostic assays for capsaicin receptor polymorphisms and aberrant capsaicin receptor expression.

Abstract translation: 本发明提供新的人类辣椒素受体和编码这些受体的核苷酸序列。 还提供编码这些受体的载体和表达这些载体的哺乳动物和非哺乳动物细胞。 还提供了用于鉴定调节辣椒素受体的化合物和辣椒素受体多态性和异常辣椒素受体表达的诊断测定法的测定。

公开(公告)号：US4458178A

公开(公告)日：1984-07-03

申请号：US426570

申请日：1982-09-29

Applicant: David L. Tenney ,  James Krause ,  John R. Welk

Inventor： David L. Tenney ,  James Krause ,  John R. Welk

IPC: H04N9/29

CPC classification number: H04N9/29

Abstract: A CRT in a CRT device is degaussed following a timed period of device inactivity and while the screen of the CRT is darkened, as well as at device turn-on or at manual activation. The screen stays darkened until data is inputted, and degaussing reoccurs during each subsequent timed period of inactivity.

Abstract translation: CRT设备中的CRT在设备不活动的定时周期和CRT的屏幕变暗以及设备开启或手动激活之间消磁。 屏幕保持黑暗，直到输入数据，并且在每个随后的不活动定时期间内消磁消失。

公开(公告)号：US20120084194A1

公开(公告)日：2012-04-05

申请号：US13324490

申请日：2011-12-13

Applicant: James Farrell ,  James Krause

Inventor： James Farrell ,  James Krause

IPC: G06Q40/04

CPC classification number: G06Q40/04

Abstract: A system mitigates market spike effects caused by conditional ordering triggering and election in an automated matching system. The system monitors trading as a result of cascading triggering of conditional orders. When an order is executed beyond a predetermined price threshold, an instrument may be flagged, allowing matching to occur only at or within the predetermined price threshold. Orders within the price threshold are matched at the price threshold against orders beyond it, dampening any instantaneous damaging effects of the price spike. The system may adjust the price threshold when market appropriate, allowing the order flow to bring the market back to whatever is the true price level. The system mitigates purely conditional order cascade driven price fluctuations, but allows the market to continuously trade in controlled price and time intervals ensuring that true market moves can still occur without price control mechanisms hindering trade matching and true price discovery.

Abstract translation: 系统减轻了在自动匹配系统中条件排序触发和选举引起的市场尖峰效应。 由于级联触发条件订单，系统监控交易。 当订单执行超过预定价格阈值时，可以标记仪器，允许仅在或在预定价格阈值内进行匹配。 在价格门槛内的订单与价格门槛相匹配，超过它的订单，抑制价格上涨的任何瞬时的破坏性影响。 该系统可以在市场适当时调整价格门槛，允许订单流量将市场恢复到真正的价格水平。 该系统减轻了纯粹的有条件订单级联驱动的价格波动，但允许市场以可控的价格和时间间隔持续交易，确保如果没有价格控制机制阻碍贸易匹配和真正的价格发现，真正的市场动向仍然可以发生。