公开(公告)号：US20100227527A1

公开(公告)日：2010-09-09

申请号：US12397990

申请日：2009-03-04

Applicant: Lanny S. Smoot ,  Timothy Caldwell ,  Gary W. Schnuckle

Inventor： Lanny S. Smoot ,  Timothy Caldwell ,  Gary W. Schnuckle

IPC: A63J19/00

CPC classification number: A63F7/0088 ,  A63F9/34 ,  A63F2003/00662 ,  A63J19/00

Abstract: An apparatus for suspending and positioning marionettes. The apparatus includes a thin, planar support membrane such as a plastic sheet. A tender vehicle is positioned on the upper side of the support membrane. A motor or other drive mechanism selectively positions the tender vehicle relative to the support membrane. The apparatus includes a puppeteer vehicle from which a marionette is suspended. The puppeteer vehicle is positioned proximate to the lower side of the support membrane opposite the tender vehicle. To support the puppeteer vehicle, one or both of the vehicles includes one or more rotatable magnetic elements such that the attractive forces support the weight of the puppeteer vehicle and the marionette. Typically, the puppeteer vehicle is a passive follower, and the drive mechanism of the tender vehicle includes motors to move the magnetic elements and position the tender and following puppeteer vehicle with its marionette to provide a show.

Abstract translation: 用于悬挂和定位牵线木偶的装置。 该装置包括薄的平面支撑膜，例如塑料片。 招标车位于支撑膜的上侧。 马达或其他驱动机构选择性地将招标车辆相对于支撑膜定位。 该装置包括木偶车辆，牵引木马从该木偶车辆悬挂。 木偶车辆定位在支撑膜的与招标车辆相对的下侧附近。 为了支持木偶车辆，一个或两个车辆包括一个或多个可旋转的磁性元件，使得吸引力支撑木偶车辆和牵线木偶的重量。 通常，木偶车辆是被动跟随器，招标车辆的驱动机构包括用于移动磁性元件的马达，并且使用其牵线木偶定位招标和跟随木偶车辆以提供展示。

公开(公告)号：US20080015183A1

公开(公告)日：2008-01-17

申请号：US11864987

申请日：2007-09-29

Applicant: Rajagopal Bakthavatchalam ,  Charles Blum ,  Harry Brielmann ,  Timothy Caldwell ,  Stephane De Lombaert ,  Kevin Hodgetts ,  Xiaozhang Zheng ,  James Krause ,  Uri Herzberg ,  Taeyoung Yoon

Inventor： Rajagopal Bakthavatchalam ,  Charles Blum ,  Harry Brielmann ,  Timothy Caldwell ,  Stephane De Lombaert ,  Kevin Hodgetts ,  Xiaozhang Zheng ,  James Krause ,  Uri Herzberg ,  Taeyoung Yoon

IPC: A61K31/517 ,  A61K31/47 ,  A61K31/519 ,  A61K31/541 ,  A61P11/14 ,  A61P17/02 ,  C07D215/58 ,  C07D237/30 ,  C07D279/12 ,  C07D471/04 ,  C07D417/12 ,  C07D413/14 ,  C07D413/10 ,  C07D401/14 ,  C07D401/10 ,  C07D239/84 ,  C07D223/04 ,  A61P25/04 ,  A61P11/16 ,  A61K31/55 ,  A61K31/5377 ,  A61K31/502

CPC classification number: C07D401/04 ,  C07D215/42 ,  C07D215/44 ,  C07D237/34 ,  C07D239/94 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D419/14 ,  C07D471/04

Abstract: Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Abstract translation: 提供了取代的喹唑啉-4-基胺类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

公开(公告)号：US20070203133A1

公开(公告)日：2007-08-30

申请号：US10592297

申请日：2005-03-11

Applicant: Timothy Caldwell

Inventor： Timothy Caldwell

IPC: A61K31/5383 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/498 ,  A61K31/4745 ,  C07D491/22 ,  C07D471/22

CPC classification number: C07D498/14 ,  C07D471/12 ,  C07D471/14 ,  C07D491/22 ,  C07D498/04

Abstract: Substituted 5,12-diaza-benzoanthracene analogues are provided, of the Formula (I) wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Abstract translation: 提供了取代的5,12-二氮杂 - 苯并蒽类似物，其中变量如本文所述。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

公开(公告)号：US20070049571A1

公开(公告)日：2007-03-01

申请号：US11495986

申请日：2006-07-28

Applicant: Linghong Xie ,  Joseph Ochterski ,  Yang Gao ,  Bingsong Han ,  Timothy Caldwell ,  Yuelian Xu ,  John Peterson ,  Ping Ge ,  Robert Ohliger

Inventor： Linghong Xie ,  Joseph Ochterski ,  Yang Gao ,  Bingsong Han ,  Timothy Caldwell ,  Yuelian Xu ,  John Peterson ,  Ping Ge ,  Robert Ohliger

IPC: A61K31/551 ,  A61K31/55 ,  A61K31/497 ,  A61K31/496 ,  A61K31/4545 ,  A61K31/454 ,  C07D403/02

CPC classification number: C07D403/06 ,  C07D207/09 ,  C07D207/14 ,  C07D211/14 ,  C07D211/34 ,  C07D211/52 ,  C07D211/58 ,  C07D211/64 ,  C07D211/72 ,  C07D213/74 ,  C07D213/82 ,  C07D215/48 ,  C07D217/02 ,  C07D237/20 ,  C07D237/22 ,  C07D237/24 ,  C07D239/47 ,  C07D241/08 ,  C07D241/20 ,  C07D243/08 ,  C07D263/32 ,  C07D271/06 ,  C07D277/56 ,  C07D277/82 ,  C07D295/033 ,  C07D295/185 ,  C07D295/192 ,  C07D295/215 ,  C07D333/70 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/08 ,  C07D491/10 ,  C07D491/107

Abstract: Dipiperazinyl ketones and related analogues are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).

Abstract translation: 提供了二吡嗪基酮和相关的类似物，以及它们的制备和使用方法。 这样的化合物通常可用于在体内或体外调节配体与组胺H3受体的结合，并且特别可用于治疗人类，驯养的伴侣动物和家畜中的各种疾病。 提供药物组合物和治疗方法，以及使用这种配体检测组胺H3受体的方法（例如，受体定位研究）。

公开(公告)号：US20060089354A1

公开(公告)日：2006-04-27

申请号：US10539031

申请日：2003-12-12

Applicant: Rajagopal Bakthavatchalam ,  Charles Blum ,  Harry Brielmann ,  Timothy Caldwell ,  Stephane DeLombaert ,  Kevin Hodgetts ,  Xiaozhang Zheng

Inventor： Rajagopal Bakthavatchalam ,  Charles Blum ,  Harry Brielmann ,  Timothy Caldwell ,  Stephane DeLombaert ,  Kevin Hodgetts ,  Xiaozhang Zheng

IPC: A61K31/5377 ,  A61K31/519 ,  A61K31/4745 ,  A61K31/4709 ,  C07D487/02 ,  C07D413/02 ,  C07D401/02 ,  C07D471/02

CPC classification number: C07D417/14 ,  C07D239/94 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  C07D491/10 ,  C07F9/65128 ,  C07F9/65583 ,  C07F9/6561

Abstract: Acid-substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Abstract translation: 提供了酸取代的喹唑啉-4-基胺类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

公开(公告)号：US20060111337A1

公开(公告)日：2006-05-25

申请号：US11250135

申请日：2005-10-12

Applicant: Rajagopal Bakthavatchalam ,  Timothy Caldwell ,  Bertrand Chenard ,  Kevin Hodgetts ,  Scott Capitosti

Inventor： Rajagopal Bakthavatchalam ,  Timothy Caldwell ,  Bertrand Chenard ,  Kevin Hodgetts ,  Scott Capitosti

IPC: A61K31/506 ,  A61K31/5377 ,  A61K31/501 ,  A61K31/498 ,  A61K31/497 ,  A61K31/496 ,  A61K31/4745 ,  C07D471/02 ,  C07D487/02

CPC classification number: C07D471/04 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14

Abstract: Substituted biaryl quinolin-4-ylamine analogues of Formula I are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Abstract translation: 提供式I的取代的联芳基喹啉-4-基胺类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

公开(公告)号：US20070232591A1

公开(公告)日：2007-10-04

申请号：US11716354

申请日：2007-03-08

Applicant: Yang Gao ,  Bingsong Han ,  Yuelian Xu ,  Timothy Caldwell ,  Linghong Xie

Inventor： Yang Gao ,  Bingsong Han ,  Yuelian Xu ,  Timothy Caldwell ,  Linghong Xie

IPC: A61K31/55 ,  A61K31/496 ,  A61K31/4709 ,  C07D403/02

CPC classification number: C07D217/04 ,  C07D217/14 ,  C07D223/16 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D491/04 ,  C07D495/04 ,  C07D497/04 ,  C07D513/04

Abstract: Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues of the Formula: are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) and other disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).

Abstract translation: 哌嗪基氧基烷基四氢异喹啉及其相关的类似物，其中变量如本文所述。 这样的化合物可用于在体内或体外调节配体与组胺H3受体的结合，并且特别可用于治疗人，家养伴侣动物和家畜中的各种中枢神经系统（CNS）和其他疾病。 本文提供的化合物可以单独施用或与一种或多种其它CNS剂组合施用，以增强其它CNS剂的作用。 提供了治疗这种病症的药物组合物和方法，以及使用这种配体检测组胺H3受体的方法（例如，受体定位研究）。

公开(公告)号：US20060194805A1

公开(公告)日：2006-08-31

申请号：US11412526

申请日：2006-04-26

Applicant: Rajagopal Bakthavatchalam ,  Charles Blum ,  Harry Brielmann ,  Timothy Caldwell ,  Daniel Cortright ,  Kevin Hodgetts ,  John Peterson ,  Xiaozhang Zheng

Inventor： Rajagopal Bakthavatchalam ,  Charles Blum ,  Harry Brielmann ,  Timothy Caldwell ,  Daniel Cortright ,  Kevin Hodgetts ,  John Peterson ,  Xiaozhang Zheng

IPC: A61K31/525 ,  A61K31/517 ,  A61K31/519 ,  A61K31/498 ,  C07D475/10 ,  C07D487/02

CPC classification number: C04B35/632 ,  C07D215/44 ,  C07D239/94 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12 ,  C07D471/04 ,  C07D475/06

Abstract: Capsaicin receptor agonists are provided. Such compounds are ligands that may be used to modulate VR1 activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to capsaicin receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Abstract translation: 提供辣椒素受体激动剂。 这样的化合物是可用于在体内或体外调节VR1活性的配体，并且特别可用于治疗对人，驯养的伴侣动物和家畜中的辣椒素受体激活有反应的病症。 还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

公开(公告)号：US20050065162A1

公开(公告)日：2005-03-24

申请号：US10152189

申请日：2002-05-21

Applicant: Alan Hutchison ,  Linda Gustavson ,  John Peterson ,  Dario Doller ,  Timothy Caldwell ,  Taeyoung Yoon ,  Wallace Pringle ,  Yiping Shen ,  Cheryl Steenstra ,  Helen Yin ,  Xiao-shu He

Inventor： Alan Hutchison ,  Linda Gustavson ,  John Peterson ,  Dario Doller ,  Timothy Caldwell ,  Taeyoung Yoon ,  Wallace Pringle ,  Yiping Shen ,  Cheryl Steenstra ,  Helen Yin ,  Xiao-shu He

IPC: G01N33/53 ,  A61K31/352 ,  A61K31/451 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/551 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P43/00 ,  C07D209/86 ,  C07D211/44 ,  C07D211/52 ,  C07D213/64 ,  C07D213/74 ,  C07D215/12 ,  C07D215/20 ,  C07D223/04 ,  C07D239/47 ,  C07D243/08 ,  C07D295/08 ,  C07D295/096 ,  C07D295/108 ,  C07D295/18 ,  C07D311/18 ,  C07D311/58 ,  C07D317/58 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D513/04 ,  G01N33/566 ,  C07D43/14

CPC classification number: C07D513/04 ,  C07D209/86 ,  C07D211/52 ,  C07D213/64 ,  C07D213/74 ,  C07D215/12 ,  C07D215/20 ,  C07D243/08 ,  C07D295/096 ,  C07D295/108 ,  C07D311/18 ,  C07D317/58 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08

Abstract: Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

Abstract translation: 提供能够调节MCH受体活性的黑色素浓缩激素受体配体（特别是1-苄基-4-芳基哌嗪，1-苄基-4-芳基哌啶和相关化合物）。 这样的配体可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗人，驯养的伴侣动物和家畜中的各种代谢，喂养和性障碍。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。

公开(公告)号：US09011197B2

公开(公告)日：2015-04-21

申请号：US12397990

申请日：2009-03-04

Applicant: Lanny S. Smoot ,  Timothy Caldwell ,  Gary W. Schnuckle

Inventor： Lanny S. Smoot ,  Timothy Caldwell ,  Gary W. Schnuckle

IPC: A63H33/00 ,  A63J19/00 ,  A63F7/00 ,  A63F9/34 ,  A63F3/00

CPC classification number: A63F7/0088 ,  A63F9/34 ,  A63F2003/00662 ,  A63J19/00

Abstract: An apparatus for suspending and positioning marionettes. The apparatus includes a thin, planar support membrane such as a plastic sheet. A tender vehicle is positioned on the upper side of the support membrane. A motor or other drive mechanism selectively positions the tender vehicle relative to the support membrane. The apparatus includes a puppeteer vehicle from which a marionette is suspended. The puppeteer vehicle is positioned proximate to the lower side of the support membrane opposite the tender vehicle. To support the puppeteer vehicle, one or both of the vehicles includes one or more rotatable magnetic elements such that the attractive forces support the weight of the puppeteer vehicle and the marionette. Typically, the puppeteer vehicle is a passive follower, and the drive mechanism of the tender vehicle includes motors to move the magnetic elements and position the tender and following puppeteer vehicle with its marionette to provide a show.

Abstract translation: 用于悬挂和定位牵线木偶的装置。 该装置包括薄的平面支撑膜，例如塑料片。 招标车位于支撑膜的上侧。 马达或其他驱动机构选择性地将招标车辆相对于支撑膜定位。 该装置包括木偶车辆，牵引木马从该木偶车辆悬挂。 木偶车辆定位在支撑膜的与招标车辆相对的下侧附近。 为了支持木偶车辆，一个或两个车辆包括一个或多个可旋转的磁性元件，使得吸引力支撑木偶车辆和牵线木偶的重量。 通常，木偶车辆是被动跟随器，招标车辆的驱动机构包括用于移动磁性元件的马达，并且使用其牵线木偶定位招标和跟随木偶车辆以提供展示。