公开(公告)号：US06181414B2

公开(公告)日：2001-01-30

申请号：US09368521

申请日：1999-08-05

申请人： Ryan S. Raz ,  Gordon Rosenblatt ,  Daniel S. Maclean

发明人： Ryan S. Raz ,  Gordon Rosenblatt ,  Daniel S. Maclean

IPC分类号： G01J300

CPC分类号： G01N21/3563 ,  G01N15/1475 ,  G01N21/3151 ,  G01N2021/3133 ,  G01N2021/3137 ,  G01N2021/3148 ,  G01N2021/3155

摘要： A multi-channel spectral imaging module for an automated testing system for cytological applications. The multi-channel spetral imaging module generates four channels of digitized images of a cytological specimen for further processing in the automated testing system. The multi-spectral imaging module comprises a visible light source and an infrared light source, an optical imaging module, a prism module, and an output stage. The cytological specimen is strobed by the visible light and infrared light sources and the illuminated images of the specimen are focussed and coupled to the prism module by the optical imaging module. The prism module breaks the illuminated image into four channels comprising three visible light channels and an infrared channel. The output stage comprises a CCD array sensor for each channel. The CCD array sensor digitizes the image for channel and produces an output for further processing. The digitized output from the infrared channel provides additional information which is used by the automated testing system. The additional information derived from the infrared channel includes segmentation information, new identifying features for the specimen, and discrimination measures independent of the visible light channels. In another embodiment, a fifth channel is provided for a reference infrared output and the two infrared channels are operated in a differential mode.

摘要翻译： 用于细胞学应用的自动化测试系统的多通道光谱成像模块。 多通道spetral成像模块生成四个通道的细胞学标本的数字化图像，用于在自动化测试系统中进一步处理。 多光谱成像模块包括可见光源和红外光源，光学成像模块，棱镜模块和输出级。 细胞学样本被可见光和红外光源选通，并且通过光学成像模块将样本的照射图像聚焦并耦合到棱镜模块。 棱镜模块将照明图像分成四个通道，包括三个可见光通道和一个红外通道。 输出级包括用于每个通道的CCD阵列传感器。 CCD阵列传感器将通道图像数字化，并产生一个输出进一步处理。 红外通道的数字化输出提供了自动测试系统使用的附加信息。 从红外线通道导出的附加信息包括分割信息，样本的新识别特征以及独立于可见光通道的鉴别度量。 在另一个实施例中，为参考红外输出提供第五通道，并且两个红外通道以差分模式操作。