公开(公告)号：US08680247B2

公开(公告)日：2014-03-25

申请号：US12668965

申请日：2008-07-17

申请人： Jonathan Alexander Terrett ,  Li-Sheng Lu ,  Haichun Huang ,  Dapeng Yao ,  Chin Pan ,  Heidi Leblanc ,  Timothy Sproul ,  Mark Yamanaka

发明人： Jonathan Alexander Terrett ,  Li-Sheng Lu ,  Haichun Huang ,  Dapeng Yao ,  Chin Pan ,  Heidi Leblanc ,  Timothy Sproul ,  Mark Yamanaka

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61K39/44 ,  C07K16/46

CPC分类号： C07K16/28 ,  A61K39/00 ,  C07K16/303 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.

摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合磷脂酰肌醇蛋白聚糖-3的人单克隆抗体。 还提供了编码磷脂酰肌醇蛋白聚糖-3抗体的核酸分子，表达载体，宿主细胞和用于表达糖蛋白聚糖-3抗体的方法。 还提供了免疫偶联物，双特异性分子和包含磷脂酰肌醇蛋白聚糖-3抗体的药物组合物。 公开了检测磷酸三钙-3的方法，以及用于治疗各种磷酸三钙3相关病症（包括肝细胞癌）的方法。

公开(公告)号：US20100209432A1

公开(公告)日：2010-08-19

申请号：US12668965

申请日：2008-07-17

申请人： Jonathan Alexander Terrette ,  Li-sheng Lu ,  Haichun Huang ,  Dapeng Yao ,  Chin Pan ,  Heidi Leblanc ,  Timothy Sproul ,  Mark Yamanaka

发明人： Jonathan Alexander Terrette ,  Li-sheng Lu ,  Haichun Huang ,  Dapeng Yao ,  Chin Pan ,  Heidi Leblanc ,  Timothy Sproul ,  Mark Yamanaka

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  A61P35/00

CPC分类号： C07K16/28 ,  A61K39/00 ,  C07K16/303 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.

摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合磷脂酰肌醇蛋白聚糖-3的人单克隆抗体。 还提供了编码磷脂酰肌醇蛋白聚糖-3抗体的核酸分子，表达载体，宿主细胞和用于表达糖蛋白聚糖-3抗体的方法。 还提供了免疫偶联物，双特异性分子和包含磷脂酰肌醇蛋白聚糖-3抗体的药物组合物。 公开了检测磷酸三钙-3的方法，以及用于治疗各种磷酸三钙3相关病症（包括肝细胞癌）的方法。