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公开(公告)号:US20100209432A1
公开(公告)日:2010-08-19
申请号:US12668965
申请日:2008-07-17
申请人: Jonathan Alexander Terrette , Li-sheng Lu , Haichun Huang , Dapeng Yao , Chin Pan , Heidi Leblanc , Timothy Sproul , Mark Yamanaka
发明人: Jonathan Alexander Terrette , Li-sheng Lu , Haichun Huang , Dapeng Yao , Chin Pan , Heidi Leblanc , Timothy Sproul , Mark Yamanaka
CPC分类号: C07K16/28 , A61K39/00 , C07K16/303 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.
摘要翻译: 本公开提供分离的单克隆抗体,特别是以高亲和力特异性结合磷脂酰肌醇蛋白聚糖-3的人单克隆抗体。 还提供了编码磷脂酰肌醇蛋白聚糖-3抗体的核酸分子,表达载体,宿主细胞和用于表达糖蛋白聚糖-3抗体的方法。 还提供了免疫偶联物,双特异性分子和包含磷脂酰肌醇蛋白聚糖-3抗体的药物组合物。 公开了检测磷酸三钙-3的方法,以及用于治疗各种磷酸三钙3相关病症(包括肝细胞癌)的方法。
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公开(公告)号:US08680247B2
公开(公告)日:2014-03-25
申请号:US12668965
申请日:2008-07-17
申请人: Jonathan Alexander Terrett , Li-Sheng Lu , Haichun Huang , Dapeng Yao , Chin Pan , Heidi Leblanc , Timothy Sproul , Mark Yamanaka
发明人: Jonathan Alexander Terrett , Li-Sheng Lu , Haichun Huang , Dapeng Yao , Chin Pan , Heidi Leblanc , Timothy Sproul , Mark Yamanaka
IPC分类号: C07K16/30 , A61K39/395 , A61K39/44 , C07K16/46
CPC分类号: C07K16/28 , A61K39/00 , C07K16/303 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.
摘要翻译: 本公开提供分离的单克隆抗体,特别是以高亲和力特异性结合磷脂酰肌醇蛋白聚糖-3的人单克隆抗体。 还提供了编码磷脂酰肌醇蛋白聚糖-3抗体的核酸分子,表达载体,宿主细胞和用于表达糖蛋白聚糖-3抗体的方法。 还提供了免疫偶联物,双特异性分子和包含磷脂酰肌醇蛋白聚糖-3抗体的药物组合物。 公开了检测磷酸三钙-3的方法,以及用于治疗各种磷酸三钙3相关病症(包括肝细胞癌)的方法。
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公开(公告)号:US20120093826A1
公开(公告)日:2012-04-19
申请号:US13254752
申请日:2010-03-05
申请人: Jonathan Alexander Terrett , Heidi Leblanc , Haichun Huang , Erika Meaddough , Chin Pan , Bingliang Chen , Chetana Rao-Naik
发明人: Jonathan Alexander Terrett , Heidi Leblanc , Haichun Huang , Erika Meaddough , Chin Pan , Bingliang Chen , Chetana Rao-Naik
IPC分类号: A61K39/395 , C12N15/13 , C12N15/63 , A61P35/02 , C12P21/08 , C12N5/16 , A61P35/00 , C07K16/28 , C12N5/10
CPC分类号: C07K16/3007 , A61K33/24 , A61K39/39558 , A61K2039/505 , C07K16/3023 , C07K2317/24 , C07K2317/41 , C07K2317/73 , C07K2317/732 , C07K2317/77 , A61K2300/00
摘要: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, more particularly engineered antibodies resulting in increased binding to Fc receptors and/or increased potency for ADCC or immunoconjugates, which specifically bind to CADM1 with high affinity. Nucleic acid molecules encoding CADM1 antibodies, expression vectors, host cells and methods for expressing the CADM1 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CADM1 antibodies are also provided. Methods for detecting CADM1, as well as methods for treating various cancers, including lung cancer and pancreatic cancer, are disclosed.
摘要翻译: 本公开内容提供分离的单克隆抗体,特别是人单克隆抗体,更特别是工程化的抗体,其导致与Fc受体的增加的结合和/或增加对具有高亲和力特异性结合CADM1的ADCC或免疫偶联物的效力。 还提供编码CADM1抗体的核酸分子,表达载体,宿主细胞和用于表达CADM1抗体的方法。 还提供了包含CADM1抗体的双特异性分子和药物组合物。 公开了用于检测CADM1的方法,以及用于治疗各种癌症的方法,包括肺癌和胰腺癌。
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公开(公告)号:US08420084B2
公开(公告)日:2013-04-16
申请号:US13254752
申请日:2010-03-05
申请人: Jonathan Alexander Terrett , Heidi Leblanc , Haichun Huang , Erika Meaddough , Chin Pan , Bingliang Chen , Chetana Rao-Naik
发明人: Jonathan Alexander Terrett , Heidi Leblanc , Haichun Huang , Erika Meaddough , Chin Pan , Bingliang Chen , Chetana Rao-Naik
IPC分类号: A61K39/395 , C07K16/00 , C07K16/46
CPC分类号: C07K16/3007 , A61K33/24 , A61K39/39558 , A61K2039/505 , C07K16/3023 , C07K2317/24 , C07K2317/41 , C07K2317/73 , C07K2317/732 , C07K2317/77 , A61K2300/00
摘要: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, more particularly engineered antibodies resulting in increased binding to Fc receptors and/or increased potency for ADCC or immunoconjugates, which specifically bind to CADM1 with high affinity. Nucleic acid molecules encoding CADM1 antibodies, expression vectors, host cells and methods for expressing the CADM1 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CADM1 antibodies are also provided. Methods for detecting CADM1, as well as methods for treating various cancers, including lung cancer and pancreatic cancer, are disclosed.
摘要翻译: 本公开内容提供分离的单克隆抗体,特别是人单克隆抗体,更特别是工程化的抗体,其导致与Fc受体的增加的结合和/或增加对具有高亲和力特异性结合CADM1的ADCC或免疫偶联物的效力。 还提供编码CADM1抗体的核酸分子,表达载体,宿主细胞和用于表达CADM1抗体的方法。 还提供了包含CADM1抗体的双特异性分子和药物组合物。 公开了用于检测CADM1的方法,以及用于治疗各种癌症的方法,包括肺癌和胰腺癌。
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