公开(公告)号：US20060229298A1

公开(公告)日：2006-10-12

申请号：US11436099

申请日：2006-05-17

申请人： Alan Hutchison ,  Linda Gustavson ,  John Peterson ,  Dario Dollar ,  Timothy Caldwell ,  Taeyoung Yoon ,  Wallace Pringle ,  Rajagopal Bakthavatchalam ,  Yiping Shen ,  Cheryl Steenstra ,  Helen Yin ,  Robert DeSimone ,  Xiao-shu He

发明人： Alan Hutchison ,  Linda Gustavson ,  John Peterson ,  Dario Dollar ,  Timothy Caldwell ,  Taeyoung Yoon ,  Wallace Pringle ,  Rajagopal Bakthavatchalam ,  Yiping Shen ,  Cheryl Steenstra ,  Helen Yin ,  Robert DeSimone ,  Xiao-shu He

IPC分类号： A61K31/496 ,  A61K31/551 ,  A61K31/495 ,  C07D403/02

CPC分类号： C07D513/04 ,  C07D209/86 ,  C07D211/52 ,  C07D213/64 ,  C07D213/74 ,  C07D215/12 ,  C07D215/20 ,  C07D243/08 ,  C07D295/096 ,  C07D295/108 ,  C07D311/18 ,  C07D317/58 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08

摘要： Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).