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公开(公告)号：US20120034193A1
公开(公告)日：2012-02-09
申请号：US13138251
申请日：2010-01-22
申请人： Daryl Rees , Antonia Orsi , Patrick Howson , Zongqin Xia , Yaer Hu
发明人： Daryl Rees , Antonia Orsi , Patrick Howson , Zongqin Xia , Yaer Hu
IPC分类号： A61K35/12 , C07J71/00 , A61P25/00 , A61P25/28 , A61P25/16 , A61P21/00 , A61P27/02 , A61P9/04 , A61P11/06 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/18 , A61P25/30 , A61P25/32 , A61P25/36 , A61P29/00 , A61P17/06 , A61P1/00 , A61P37/08 , A61P17/04 , A61P1/04 , A61P1/18 , A61P11/02 , A61P11/14 , A61P19/02 , A61P9/10 , A61P37/00 , A61P37/06 , A61P35/00 , A61P19/08 , A61P43/00 , A61K31/58
CPC分类号： A61K31/58 , A61K31/7048
摘要： An agent selected from A/B-cis furostane, furostene, spirostane and spirostene steroidal sapogenins and ester, ether, ketone and glycosylated forms thereof is used to induce self-regulated homeostasis of neurotrophic factors (NFs), for example BDNF and/or GDNF, NFs with limited and manageable side effects in a subject, by modulating NFs in a non-toxic manner under homeostatic control. An effective amount of at least one such agent is administered to the subject, particularly in the treatment or prevention of a range of NF-mediated disorders, particularly neurological, psychiatric, inflammatory, allergic, immune and neoplastic disorders, and in the restoration or normalisation of neuronal and other function in or in relation to any damaged or abnormal tissue, including when assisting tissue (for example, skin, bone, eye and muscle) healing and general skin, bone, eye and muscle health.
摘要翻译： 使用选自A / B-顺式呋喃斯坦，呋喃葡萄烯，螺甾烷和螺甾烷基甾体皂苷元及其酯，醚，酮及其糖基化形式的药剂诱导神经营养因子（NF）的自我调节的体内平衡，例如BDNF和/或GDNF ，通过在稳态控制下以无毒的方式调节NF，在受试者中具有有限和易于治疗的副作用的NF。 特别是治疗或预防一系列NF介导的疾病，特别是神经系统疾病，精神病学，炎症，过敏性，免疫和肿瘤性疾病，以及在恢复或正常化过程中向受试者施用有效量的至少一种此类药剂 包括当辅助组织（例如皮肤，骨骼，眼睛和肌肉）愈合和一般皮肤，骨骼，眼睛和肌肉健康时，神经元和其他功能在任何损伤或异常组织中或与其相关。
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2.发明申请公开(公告)号：US20080003268A1
公开(公告)日：2008-01-03
申请号：US11811166
申请日：2007-06-07
申请人： Salomon Abrahamse , Kevin Povey , Daryl Rees
发明人： Salomon Abrahamse , Kevin Povey , Daryl Rees
IPC分类号： A61K9/00 , A61K31/7028 , A61P1/00
CPC分类号： A61K36/27 , A23L7/126 , A23L23/00 , A23L33/105 , A23L33/12
摘要： An inherently nourishing edible appetite suppressant unit serving product comprising a steroidal glycoside, preferably obtainable from Hoodia plants, in a defined proportion to the total energy content. A method of lowering daily calorie (daily energy) intake is also disclosed.
摘要翻译： 本发明的食用食欲抑制剂单元，其以与总能量含量成正比例的比例提供产品，其包含优选以Hoodia植物获得的甾族糖苷。 还公开了降低日热量（日能量）摄入量的方法。
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3.发明申请5-Beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia 失效5-β-皂苷元和假发生素衍生物及其在治疗痴呆中的应用公开(公告)号：US20060276415A1
公开(公告)日：2006-12-07
申请号：US11502784
申请日：2006-08-11
申请人： Paul Barraclough , Jim Hanson , Phil Gunning , Daryl Rees , Zongqin Xia , Yaer Hu
发明人： Paul Barraclough , Jim Hanson , Phil Gunning , Daryl Rees , Zongqin Xia , Yaer Hu
IPC分类号： A61K31/58
CPC分类号： C07J71/00 , C07J71/0005
摘要： The invention discloses the use of sapogenin derivatives in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical compositions are also disclosed
摘要翻译： 本发明公开了使用皂角苷衍生物治疗认知障碍和类似病症。 还公开了治疗方法和药物组合物
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公开(公告)号：US07138427B2
公开(公告)日：2006-11-21
申请号：US10109095
申请日：2002-03-28
申请人： Paul Barraclough , Jim Hanson , Phil Gunning , Daryl Rees , Zongqin Xia , Yaer Hu
发明人： Paul Barraclough , Jim Hanson , Phil Gunning , Daryl Rees , Zongqin Xia , Yaer Hu
IPC分类号： A61K31/35 , C07D493/20
CPC分类号： C07J71/00 , C07J71/0005
摘要： The invention discloses the use of sapogenin derivatives in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical compositions are also disclosed
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公开(公告)号：US20060165757A1
公开(公告)日：2006-07-27
申请号：US11346046
申请日：2006-02-02
申请人： Paul Barraclough , Jim Hanson , Phil Gunning , Daryl Rees , Zongqin Xia , Yaer Hu
发明人： Paul Barraclough , Jim Hanson , Phil Gunning , Daryl Rees , Zongqin Xia , Yaer Hu
摘要： The invention discloses the use of 5-hydroxysapogenin derivatives in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical composition are also disclosed.
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6.发明授权5-Beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia 失效5-β-皂苷元和假发生素衍生物及其在治疗痴呆中的应用公开(公告)号：US07507720B2
公开(公告)日：2009-03-24
申请号：US11502784
申请日：2006-08-11
申请人： Paul Barraclough , Jim Hanson , Phil Gunning , Daryl Rees , Zongqin Xia , Yaer Hu
发明人： Paul Barraclough , Jim Hanson , Phil Gunning , Daryl Rees , Zongqin Xia , Yaer Hu
IPC分类号： A61K31/58
CPC分类号： C07J71/00 , C07J71/0005
摘要： The invention discloses the use of sapogenin derivatives in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical compositions are also disclosed.
摘要翻译： 本发明公开了使用皂角苷衍生物治疗认知障碍和类似病症。 还公开了治疗方法和药物组合物。
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公开(公告)号：US20100087411A1
公开(公告)日：2010-04-08
申请号：US12539253
申请日：2009-08-11
申请人： Paul Barraclough , Jim Hanson , Phil Gunning , Daryl Rees , Zongqin Xia , Yaer Hu
发明人： Paul Barraclough , Jim Hanson , Phil Gunning , Daryl Rees , Zongqin Xia , Yaer Hu
CPC分类号： C07J71/0005
摘要： The invention discloses substituted sapogenins and their use in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical composition are also disclosed
摘要翻译： 本发明公开了取代的皂苷元及其在治疗认知障碍和类似病症中的用途。 还公开了治疗方法和药物组合物
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8.发明申请Sapogenin derivatives and their use in the treatment of cognitive dysfunction 审中-公开皂苷衍生物及其在治疗认知功能障碍中的应用公开(公告)号：US20080021004A1
公开(公告)日：2008-01-24
申请号：US11894120
申请日：2007-08-20
申请人： Paul Barraclough , Jim Hanson , Phil Gunning , Daryl Rees , Zongqin Xia , Yaer Hu
发明人： Paul Barraclough , Jim Hanson , Phil Gunning , Daryl Rees , Zongqin Xia , Yaer Hu
CPC分类号： C07J71/0005 , C07J9/00 , C07J71/00
摘要： The invention discloses the use of sapogenin derivatives in the treatment of cognitive dysfunction and similar conditions. Methods of treatment and pharmaceutical composition are also disclosed.
摘要翻译： 本发明公开了使用皂角苷衍生物治疗认知功能障碍和类似病症。 还公开了治疗方法和药物组合物。
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公开(公告)号：US20050130948A1
公开(公告)日：2005-06-16
申请号：US10507000
申请日：2003-03-27
申请人： Daryl Rees , Phil Gunning , Antonia Orsi , Zongqin Xia , Yaer Hu
发明人： Daryl Rees , Phil Gunning , Antonia Orsi , Zongqin Xia , Yaer Hu
IPC分类号： A61K31/58 , A61K31/585 , A61K31/655 , A61P9/02 , A61P9/04 , A61P11/06 , A61P21/00 , A61P21/04 , A61P25/08 , A61P25/16 , A61P25/28 , A61P27/00 , C07J20060101 , C07J71/00
CPC分类号： A61K31/58 , A61K31/655 , C07J71/00 , C07J71/0005 , Y02A50/465
摘要： The invention discloses therapeutic methods and uses of certain steroidal sapogenins, related compounds and derivatives thereof, in the treatment of non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, motor-sensory neurodegeneration or receptor dysfunction or loss in the absence of cognitive, neural and neuromuscular impairment.
摘要翻译： 本发明公开了某些甾体皂苷元，相关化合物及其衍生物在治疗非认知神经退行性疾病，非认知性神经肌肉变性，运动感觉神经变性或受体功能障碍或不存在认知神经和神经损伤的情况下的治疗方法和用途。 神经肌肉损伤
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公开(公告)号：US20110190249A1
公开(公告)日：2011-08-04
申请号：US13085225
申请日：2011-04-12
申请人： Daryl REES , Phil Gunning , Antonia Orsi , Zongqin Xia , Yaer Hu
发明人： Daryl REES , Phil Gunning , Antonia Orsi , Zongqin Xia , Yaer Hu
CPC分类号： A61K31/655 , A61K31/58 , C07J71/0005 , Y02A50/465
摘要： The invention discloses therapeutic methods and uses of certain steroidal sapogenins, related compounds and derivatives thereof, in the treatment of non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, motor-sensory neurodegeneration or receptor dysfunction or loss in the absence of cognitive, neural and neuromuscular impairment.
摘要翻译： 本发明公开了某些甾体皂苷元，相关化合物及其衍生物在治疗非认知神经退行性疾病，非认知性神经肌肉变性，运动感觉神经变性或受体功能障碍或不存在认知神经和神经损伤的情况下的治疗方法和用途。 神经肌肉损伤
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