公开(公告)号：US07078487B2

公开(公告)日：2006-07-18

申请号：US10372095

申请日：2003-02-25

申请人： Harald Jüppner ,  David A Rubin

发明人： Harald Jüppner ,  David A Rubin

IPC分类号： C07K14/72 ,  C07K14/435

CPC分类号： C07K14/461 ,  A61K38/00 ,  C07K14/723

摘要： The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present invention share homology with previously identified parathyroid hormone (PTH)/parathyroid related protein (PTHrP) receptors. Isolated nucleic acid molecules are provided encoding the zebrafish PTH1R and PTH3R receptors. PTH1R and PTH3R receptor polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of PTH1R and PTH3R receptor activity and to diagnostic and therapeutic methods.

摘要翻译： 本发明涉及从斑马鱼分离的新型甲状旁腺激素（PTH）和甲状旁腺激素相关蛋白（PTHrP）受体（PTH1R和PTH3R）。 本发明的受体与以前鉴定的甲状旁腺激素（PTH）/甲状旁腺相关蛋白（PTHrP）受体共享同源性。 提供分离的核酸分子，其编码斑马鱼PTH1R和PTH3R受体。 还提供了PTH1R和PTH3R受体多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定PTH1R和PTH3R受体活性的激动剂和拮抗剂以及诊断和治疗方法的筛选方法。

公开(公告)号：US5524382A

公开(公告)日：1996-06-11

申请号：US287012

申请日：1994-08-08

申请人： David A. Rubin

发明人： David A. Rubin

IPC分类号： A01G17/06 ,  A01G17/14

CPC分类号： A01G17/06

摘要： A decorative ornament which can be mounted on an inside or outside wall of a house or other structure and which simulates the appearance of a column. The ornament comprises an upper section which simulates the capital of a column, a lower section which simulates the base of a column, and a folded wire strung between the upper and lower sections which has parallel segments simulating the fluting of a column. When mounted on a wall facing a garden or on an inside wall, the ornament can serve as a trellis with the wires supporting plants, flowers or vines.

摘要翻译： 可以安装在房屋或其他结构的内壁或外墙上并且模拟柱的外观的装饰性装饰品。 装饰品包括模拟柱的首都的上部，模拟柱的底部的下部，以及在上部和下部之间的折叠线，该折叠线具有模拟柱的凹槽的平行部分。 当安装在面向花园或内墙上的墙壁上时，装饰品可以用支撑植物，花卉或葡萄藤的电线作为格子。

公开(公告)号：US06541220B1

公开(公告)日：2003-04-01

申请号：US09449632

申请日：1999-11-30

申请人： Harald Jüppner ,  David A. Rubin

发明人： Harald Jüppner ,  David A. Rubin

IPC分类号： C12N1512

CPC分类号： C07K14/461 ,  A61K38/00 ,  C07K14/723

摘要： The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present invention share homology with previously identified parathyroid hormone (PTH)/parathyroid related protein (PTHrP) receptors. Isolated nucleic acid molecules are provided encoding the zebrafish PTH1R and PTH3R receptors. PTH1R and PTH3R receptor polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of PTH1R and PTH3R receptor activity and to diagnostic and therapeutic methods.

摘要翻译： 本发明涉及从斑马鱼分离的新型甲状旁腺激素（PTH）和甲状旁腺激素相关蛋白（PTHrP）受体（PTH1R和PTH3R）。 本发明的受体与以前鉴定的甲状旁腺激素（PTH）/甲状旁腺相关蛋白（PTHrP）受体共享同源性。 提供分离的核酸分子，其编码斑马鱼PTH1R和PTH3R受体。 还提供了PTH1R和PTH3R受体多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定PTH1R和PTH3R受体活性的激动剂和拮抗剂以及诊断和治疗方法的筛选方法。