公开(公告)号：US5922730A

公开(公告)日：1999-07-13

申请号：US103445

申请日：1998-06-24

Applicant: David Cheng Hu ,  Alexander Aleksey Greenfield ,  Thomas Joseph Caggiano ,  Craig Eugene Caufield

Inventor： David Cheng Hu ,  Alexander Aleksey Greenfield ,  Thomas Joseph Caggiano ,  Craig Eugene Caufield

IPC: C07D498/18 ,  A61K31/445 ,  A61K31/435 ,  C07D471/04

CPC classification number: C07D498/18

Abstract: This invention relates to compounds which possess immunosuppressive and/or anti tumor and/or antinflammatory activity in vivo and/or inhibit thymocyte proliferation in vitro. These compounds are therefore useful in the treaiment of transplantation rejection, autoimmune diseases such as lupus, rheumatoid ardiritis, diabetes mellitus, multiple sclerosis and in the treatment of Candida albicans infections and also in treatment of diseases of inflammation. These compounds are represented by the formula below ##STR1## wherein W and Y are OR.sup.1 and X and Z together form a bond or W and X are OR.sup.2 and Y and Z together form a bond, wherein:R.sup.1 is selected from --(CH.sub.2).sub.n --Ar with a proviso that Ar is not phenyl,--(CH.sub.2 CH.sub.2 O).sub.n CH.sub.3 with a proviso that n is greater than one,--CH.sub.2 CH.sub.2 CH.sub.2 O(CH.sub.2 CH.sub.2 O).sub.m --CH.sub.3,--(CH.sub.2).sub.n --CH.sub.2 CH(OR.sup.3)CH.sub.2 OR.sup.4 where R.sup.3 and R.sup.4 are H, C.sub.1 -C.sub.10 alkyl, or R.sup.3 and R.sup.4 together are ethylene, methylene or dimethylmethylene;--CH.sub.2 (CH.sub.2).sub.n --OR.sup.3 with a proviso that R.sup.3 is not H, C.sub.1 -C.sub.10 alkyl, or C(O)C.sub.1 -C.sub.10 alkyl;and --CH.sub.2 (CH.sub.2).sub.n --X where X is F, Cl, Br or I;R.sup.2 is selected from H, C.sub.1 -C.sub.10 alkyl, Ar(CH.sub.2).sub.n --, C.sub.3 -C.sub.10 alkenyl, --(CH.sub.2 (CH.sub.2 O).sub.n CH.sub.3, --CH.sub.2 CH.sub.2 CH.sub.2 O(CH.sub.2 CH.sub.2 O).sub.m --CH.sub.3, --CH.sub.2 (CH.sub.2).sub.n --OR.sup.3, --CH.sub.2 (CH.sub.2).sub.n --Xwhere X is F, Cl, Br or I;and --(CH.sub.2).sub.n --CH.sub.2 CH(OR.sup.5)CH.sub.2 OR.sup.6 where R.sup.5 and R.sup.6 are selected independently from H, C.sub.1 -C.sub.10 alkyl, --(CH.sub.2).sub.n --Ar, --CONH(CH.sub.2).sub.n --Ar or COC(CH.sub.3).sub.2 --(CH.sub.2).sub.n --Ar, --COR.sup.7 and --CO.sub.2 R.sup.7, where R.sup.7 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, or Ar; or R.sup.5 and R.sup.6 together are methylene, ethylene, or dimethylmethylene;R.sup.3 and R.sup.4 indepently are H, methyl, --(CH.sub.2).sub.n CH.sub.3, --(CH.sub.2).sub.n Ar, --(CH.sub.2).sub.n CH.dbd.CH.sub.2, --C(O)R.sup.7, --CO.sub.2 R.sup.7, --CONH(CH.sub.2).sub.n Ar or --C(O)C(CH.sub.3).sub.2 --(CH.sub.2).sub.n Ar;Ar is selected independently from phenyl, pyridinyl, quinolinyl, indolyl, furanyl, 1, 2, 3-triazolyl and tetrazolyl;n=1-10 independently; andm=1-5 independently,or a pharmaceutically acceptable acid addition salt where one can be formed.

公开(公告)号：US20130304535A1

公开(公告)日：2013-11-14

申请号：US13940629

申请日：2013-07-12

Applicant: David Cheng Hu ,  Charles Nelson ,  Tim Landvoigt ,  James Tarver ,  Claribel Chan

Inventor： David Cheng Hu ,  Charles Nelson ,  Tim Landvoigt ,  James Tarver ,  Claribel Chan

IPC: G06Q10/06

CPC classification number: G06Q10/0637 ,  G06Q10/067 ,  G06Q10/10

Abstract: Systems and techniques to allow a user to design and manage business solutions. The business solution management system (150) comprises a portal layer (112), an application layer (104) and a data repository (106). The portal layer (112) comprises at least first and second agents (204, 208). The application layer (104) comprises at least first and second software applications (220, 224). The first and second agents (204, 208) provide user interfaces to the first and second software applications (220, 224). The first software application (220) is operable to allow a user to design a business solution with user parameters and user-selectable, pre-defined business process objects and pre-defined technology objects. The second software application (224) is operable to allow a user to manage the business solution. The data repository (106) comprises the pre-defined business objects (316) and pre-defined technology objects (314).

Abstract translation: 允许用户设计和管理业务解决方案的系统和技术。 业务解决方案管理系统（150）包括门户层（112），应用层（104）和数据存储库（106）。 入口层（112）包括至少第一和第二代理（204,208）。 应用层（104）至少包括第一和第二软件应用（220,224）。 第一和第二代理（204,208）向第一和第二软件应用程序（220,224）提供用户界面。 第一软件应用程序（220）可操作以允许用户设计具有用户参数和用户可选择的预定义业务处理对象和预定义技术对象的业务解决方案。 第二软件应用程序（224）可操作以允许用户管理业务解决方案。 数据存储库（106）包括预定义的业务对象（316）和预定义的技术对象（314）。