-
公开(公告)号：US07161057B2
公开(公告)日：2007-01-09
申请号：US10243087
申请日：2002-09-12
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0337 , C07K14/765 , C12N9/6424 , C12N15/63
摘要： The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids.
-
2.发明授权公开(公告)号：US06509514B1
公开(公告)日：2003-01-21
申请号：US09528120
申请日：2000-03-17
IPC分类号： A01K67027
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0337 , C07K14/765 , C12N9/6424 , C12N15/63
摘要： The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised xenogeneic transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection.
摘要翻译： 本发明的特征在于非人动物模型，其易受人类肝营养性病原体特别是人丙型肝炎病毒（HCV）的感染。 该模型基于具有人 - 小鼠嵌合肝的非人免疫受损的异种转基因动物，其中转基因提供在肝脏中表达尿激酶型纤溶酶原激活物。 本发明还涉及用于鉴定候选治疗剂的方法，例如具有抗HCV感染的抗病毒活性的试剂。
-
公开(公告)号：US07498479B2
公开(公告)日：2009-03-03
申请号：US11517941
申请日：2006-09-07
IPC分类号： A01K67/00 , A01K67/033 , A01K67/027 , C12N15/00
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0337 , C07K14/765 , C12N9/6424 , C12N15/63
摘要： The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids.
摘要翻译： 本发明的特征在于非人动物模型，其易受人类肝营养性病原体特别是人丙型肝炎病毒（HCV）的感染。 该模型基于具有人 - 小鼠嵌合肝的非人免疫受损转基因动物，其中转基因提供在肝脏中表达尿激酶型纤溶酶原激活物。 本发明还涉及用于鉴定候选治疗剂的方法，例如具有抗HCV感染的抗病毒活性的试剂。 本发明的动物也可用于评估各种药物的毒性，以及药物在降低血脂中的活性。
-
-
搜索结果
3 条记录 (耗时 0.014 秒)
