公开(公告)号：US06423334B1

公开(公告)日：2002-07-23

申请号：US09163510

申请日：1998-09-30

申请人： David J. Brayden ,  Jacqueline M. Dee

发明人： David J. Brayden ,  Jacqueline M. Dee

IPC分类号： A61K900

CPC分类号： A61K47/14 ,  Y10S514/80 ,  Y10S514/802 ,  Y10S514/807 ,  Y10S514/808 ,  Y10S514/822

摘要： A composition for enteral administration having a non-ionic vegetable oil GIT absorption enhancer capable of increasing the enteral absorbability of drugs, especially oral absorbability of hydrophilic and macromolecular drugs. The non-ionic vegetable oil GIT absorption enhancer, particularly Babassu oil or a derivative thereof, is capable of enhancing the uptake of a drug from the gastrointestinal tract so as to allow therapeutically effective amounts of the drug to be transported across the GIT of an animal such as a human without significant toxic side effects.

摘要翻译： 一种用于肠内给药的组合物，其具有能够增加药物的肠内吸收性的非离子植物油GIT吸收促进剂，特别是亲水性和大分子药物的口服吸收性。 非离子植物油GIT吸收促进剂，特别是巴布苏油或其衍生物能够增强药物从胃肠道的摄取，以便允许治疗有效量的药物跨越动物的GIT转运 如人体无明显毒副作用。

公开(公告)号：US20080254134A1

公开(公告)日：2008-10-16

申请号：US12144130

申请日：2008-06-23

申请人： David J. Brayden

发明人： David J. Brayden

IPC分类号： A61K9/14 ,  A61K39/00 ,  A61K39/10

CPC分类号： A61K9/0019 ,  A61K9/0024 ,  A61K9/1647 ,  A61K39/099 ,  A61K2039/55555 ,  A61K2039/57 ,  Y10S530/825

摘要： A method of inducing either a TH1 polarised immune response, a TH2 polarised immune response or a combined TH1 and TH2 response to an antigen and associated vaccine formulations are disclosed. A method is provided for inducing a polarised TH1 response by parenteral administration of microparticles sized such that at least 50% of the microparticles are less than 5 μm, the microparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Additionally, a method is provided for inducing a polarised TH2 response by parenteral administration of nanoparticles sized such that at least 50% of the nanoparticles are less than 600 nm, the nanoparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Vaccine formulations containing the B. pertussis antigens PTd, FHA or a combination of PTd and FHA are provided.

摘要翻译： 诱导T 1 H 1偏振免疫应答，T H 2 H 2极化免疫应答或组合T H H 1和T H 1的极性免疫应答的方法， 公开了对抗原和相关疫苗制剂的反应。 提供了通过胃肠外给药微粒的尺寸使得至少50％的微粒小于5μm的微粒诱导极化的T H 1应答的方法，所述微粒含有被生物降解的包裹的抗原 聚合物。 此外，提供了一种通过胃肠外施用纳米粒子来诱导极化T H 2 H 2应答的方法，所述纳米颗粒的尺寸使得至少50％的纳米颗粒小于600nm，所述纳米颗粒含有被包被或被 可生物降解的聚合物。 提供含有百日咳杆菌抗原PTd，FHA或PTd和FHA的组合的疫苗制剂。

公开(公告)号：US07087236B1

公开(公告)日：2006-08-08

申请号：US09386266

申请日：1999-08-31

申请人： David J. Brayden

发明人： David J. Brayden

IPC分类号： A61K45/00 ,  A61K39/295 ,  A61K39/116 ,  A61K39/00 ,  A61K39/02

CPC分类号： A61K9/0019 ,  A61K9/0024 ,  A61K9/1647 ,  A61K39/099 ,  A61K2039/55555 ,  A61K2039/57 ,  Y10S530/825

摘要： A method of inducing either a TH1 polarized immune response, a TH2 polarized immune response or a combined TH1 and TH2 response to an antigen and associated vaccine formulations are disclosed. A method is provided for inducing a polarized TH1 response by parenteral administration of microparticles sized such that at least 50% of the microparticles are less than 5 μm. The microparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Additionally, a method is provided for inducing a polarized TH2 response by parenteral administration of nanoparticles sized such that at least 50% of the nanoparticles are less than 600 nm, the nanoparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Vaccine formulations containing the B. pertussis antigens PTd, FHA or a combination of PTd and FHA are provided.

摘要翻译： 诱导T 1 H 1偏振免疫应答，T H 2 H 2极化免疫应答或组合T H H 1和T H 1的极性免疫应答的方法， 公开了对抗原和相关疫苗制剂的反应。 提供了通过肠胃外给药微粒的尺寸使得至少50％的微粒小于5μm的诱导极化T H 1 H应答的方法。 含有由可生物降解聚合物包埋或包封的抗原的微粒。 此外，提供了一种通过胃肠外施用纳米粒子来诱导极化T H 2 H 2应答的方法，所述纳米颗粒的尺寸使得至少50％的纳米颗粒小于600nm，所述纳米颗粒含有被包被或被 可生物降解的聚合物。 提供含有百日咳杆菌抗原PTd，FHA或PTd和FHA的组合的疫苗制剂。