利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

17 条记录 (耗时 0.017 秒)

    Co-extruded oxidation-resistant polyethylene pipe and method of manufacture
    1.
    发明申请
    Co-extruded oxidation-resistant polyethylene pipe and method of manufacture 审中-公开
    共挤出抗氧化聚乙烯管及其制造方法

    公开(公告)号：US20120305083A1

    公开(公告)日：2012-12-06

    申请号：US13134295

    申请日：2011-06-04

    申请人： Michael E. Dahl ,  David M. Fink

    发明人： Michael E. Dahl ,  David M. Fink

    IPC分类号： F15D1/00 ,  B32B1/06 ,  F16L9/14

    CPC分类号： F16L9/133 ,  B29C48/09 ,  B29C48/21 ,  B29C48/30 ,  B29C48/335 ,  B29C48/336 ,  B32B1/08 ,  B32B27/08 ,  B32B2250/05 ,  B32B2597/00 ,  Y10T137/0318

    摘要： A co-extruded multi-layer plastic pipe and method of manufacture are disclosed in which a first extruder melts and extrudes a first plastic material into the outer annulus of a coaxial extrusion die to form an outer pipe layer, and a second extruder melts and extrudes a highly oxidation-resistant plastic material into the inner annulus of said coaxial extrusion die under a blanket of inert gas to create an inner pipe layer, whereby the outer and inner pipe layers are fused together under the protection of the inert gas blanket which prevents premature degradation of the oxidation-resistant inner layer until the finished extruded pipe has cooled and solidified.

    摘要翻译： 公开了一种共挤出多层塑料管及其制造方法，其中第一挤出机将第一塑料材料熔化并挤出到同轴挤出模头的外环中以形成外管层，第二挤出机熔融挤出 在惰性气体的毯子下将高抗氧化塑料材料注入到所述同轴挤出模头的内环中以产生内管层，由此在惰性气体保护层的保护下，外管层和内管层被熔合在一起，这防止过早 抗氧化内层的降解，直到成品挤出管冷却固化。

    5-(1-aminocyclohexyl)-2(1H)-pyridinone and related compounds
    3.
    发明授权
    5-(1-aminocyclohexyl)-2(1H)-pyridinone and related compounds 失效
    5-（1-氨基环己基）-2（1H） - 吡啶酮及相关化合物

    公开(公告)号：US5112981A

    公开(公告)日：1992-05-12

    申请号：US710472

    申请日：1991-06-05

    申请人： Richard C. Effland ,  David M. Fink

    发明人： Richard C. Effland ,  David M. Fink

    IPC分类号： C07D213/64

    CPC分类号： C07D213/64

    摘要： There are described compounds of the formula ##STR1## where n is 1, 2 or 3;R.sub.1 is hydrogen, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl, loweralkyl, arylloweralkyl, ##STR2## R.sub.5 and R.sub.6 being independently loweralkyl or alternatively the group ##STR3## taken as a whole is ##STR4## R.sub.2 is hydrogen, loweralkyl, loweralkenyl, arylloweralkyl, --CH.sub.2 C.tbd.CH, ##STR5## R.sub.7 and R.sub.8 being independently loweralkyl or alternatively the group ##STR6## taken as a whole is ##STR7## R.sub.3 is hydrogen or loweralkyl; and R.sub.4 is hydrogen or loweralkyl;which compounds are useful as analgesic agents and also for treating various memory dysfunctions.

    摘要翻译： 描述了式（II）的化合物，其中n是1,2或3; R 1是氢，甲酰基，低级烷基羰基，芳基低级烷基羰基，低级烷基，芳基低级烷基，R 5和R 6独立地是低级烷基，或者作为整体取代的基团R 2是氢，低级烷基，低级烯基，芳基低级烷基 R 3和R 8独立地是低级烷基，或者作为整体取代的基团是R 3是氢或低级烷基; 和R4是氢或低级烷基; 哪些化合物可用作镇痛剂并且还用于治疗各种记忆功能障碍。

    2,6-methano-1,3-benzodiazocine compounds which have useful pharmaceutical utility
    4.
    发明授权
    2,6-methano-1,3-benzodiazocine compounds which have useful pharmaceutical utility 失效
    具有有用的药物效用的2,6-亚甲基-1,3-苯并二氮辛腈化合物

    公开(公告)号：US5010083A

    公开(公告)日：1991-04-23

    申请号：US446743

    申请日：1989-12-06

    申请人： Richard C. Allen ,  Marc N. Agnew ,  David M. Fink

    发明人： Richard C. Allen ,  Marc N. Agnew ,  David M. Fink

    IPC分类号： C07D471/08

    CPC分类号： C07D471/08

    摘要： Novel 2,6-methano-1,3-benzodiazocines, intermediates, processes for the preparation thereof, and methods for alleviating pain and for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease, utilizing compounds or compositions thereof are disclosed.

    摘要翻译： 新颖的2,6-亚甲基-1,3-苯并二氮杂环丁烷，中间体，其制备方法，利用化合物或组合物，减轻疼痛和减轻胆碱能功能降低的各种记忆障碍功能如阿尔茨海默病的方法， 披露

    Heteroaryl-8-azabicyclo[3,2,1]octanes as antipsychotic agents, 5-HT.sub.3 receptor antagonists and inhibitors of the reuptake of serotonin
    7.
    发明授权
    Heteroaryl-8-azabicyclo[3,2,1]octanes as antipsychotic agents, 5-HT.sub.3 receptor antagonists and inhibitors of the reuptake of serotonin 失效
    杂芳基-8-氮杂双环[3,2,1]辛烷作为抗精神病药，5-HT3受体拮抗剂和5-羟色胺再摄取抑制剂

    公开(公告)号：US5334599A

    公开(公告)日：1994-08-02

    申请号：US37134

    申请日：1993-03-25

    申请人： Edward J. Glamkowski ,  David M. Fink ,  Barbara E. Kurys ,  Yulin Chiang

    发明人： Edward J. Glamkowski ,  David M. Fink ,  Barbara E. Kurys ,  Yulin Chiang

    IPC分类号： C07D451/02 ,  C07D401/04 ,  A61K31/46 ,  C07D413/04 ,  C07D417/04

    CPC分类号： C07D451/02

    摘要： This invention relates to compounds of the formula ##STR1## where X is --O--, --S-- or --NH--;Y is hydrogen, halogen and loweralkoxy;p is 1 or 2;n is 2, 3 or 4;R is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, amino, loweralkylamino, nitro, loweralkylthio, trifiuoromethoxy, cyano, trifiuoromethyl, ##STR2## R.sub.1 is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, carboxyl, loweralkylamino, nitro, loweralkylthio, cyano, and trifiuoromethyl;m is 1 or 2; a pharmaceutically acceptable acid addition salt thereof and, where applicable the geometric and optical isomers and racemic mixtures thereof.The compounds and compositions of this invention are useful as antipsychotic as 5-HT.sub.3 receptor antagonists and as inhibitors of the reuptake of serotonin.

    摘要翻译： 本发明涉及式（I）的化合物，其中X是-O - ， - S-或-NH-; Y是氢，卤素和低级烷氧基; p为1或2; n为2,3或4; R是氢，低级烷基，低级烷氧基，羟基，卤素，氨基，低级烷基氨基，硝基，低级烷硫基，三氟甲氧基，氰基，三氟甲基，R1是氢，低级烷基，低级烷氧基，卤素，羟基，羧基，低级烷基氨基，硝基，低级烷硫基，氰基 和三氟甲基; m为1或2; 其药学上可接受的酸加成盐，以及适用的几何和旋光异构体及其外消旋混合物。 本发明的化合物和组合物可用作5-HT 3受体拮抗剂的抗精神病药和5-羟色胺再摄取的抑制剂。

    Process of preparing 2,6-methano-1,3-benzodiazocine compounds
    8.
    发明授权
    Process of preparing 2,6-methano-1,3-benzodiazocine compounds 失效
    制备2,6-亚甲基-1,3-苯并二氮辛腈的方法

    公开(公告)号：US5264575A

    公开(公告)日：1993-11-23

    申请号：US901638

    申请日：1992-06-19

    申请人： Richard C. Allen ,  Marc N. Agnew ,  David M. Fink

    发明人： Richard C. Allen ,  Marc N. Agnew ,  David M. Fink

    IPC分类号： C07D471/08 ,  C07D221/02

    CPC分类号： C07D471/08

    摘要： Novel 2,6-methano-1,3-benzodiazocines, intermediates, processes for the preparation thereof, and methods for alleviating pain and for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease, utilizing compounds or compositions thereof are disclosed.

    摘要翻译： 新颖的2,6-亚甲基-1,3-苯并二氮杂环丁烷，中间体，其制备方法，利用化合物或组合物，减轻疼痛和减轻胆碱能功能降低的各种记忆障碍功能如阿尔茨海默病的方法， 披露

    2,6-methano-1,3-benzodiazocine compounds
    9.
    发明授权
    2,6-methano-1,3-benzodiazocine compounds 失效
    2,6-亚甲基-1,3-苯并二氮辛啶化合物

    公开(公告)号：US5097033A

    公开(公告)日：1992-03-17

    申请号：US638933

    申请日：1991-01-09

    申请人： Richard C. Allen ,  Marc N. Agnew ,  David M. Fink

    发明人： Richard C. Allen ,  Marc N. Agnew ,  David M. Fink

    IPC分类号： C07D471/08

    CPC分类号： C07D471/08

    摘要： Novel 2,6-methano-1,3-benzodiazocines, intermediates, processes for the preparation thereof, and methods for alleviating pain and for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease, utilizing compounds or compositions thereof are disclosed.

    摘要翻译： 新颖的2,6-亚甲基-1,3-苯并二氮杂环丁烷，中间体，其制备方法，利用化合物或组合物，减轻疼痛和减轻胆碱能功能降低的各种记忆障碍功能如阿尔茨海默病的方法， 披露

    5-(1-aminocyclohexyl)-2(1H)-pyridinone and related compounds
    10.
    发明授权
    5-(1-aminocyclohexyl)-2(1H)-pyridinone and related compounds 失效
    5-（1-氨基环己基）-2（1H） - 吡啶酮及相关化合物

    公开(公告)号：US5039809A

    公开(公告)日：1991-08-13

    申请号：US594496

    申请日：1990-10-09

    申请人： Richard C. Effland ,  David M. Fink

    发明人： Richard C. Effland ,  David M. Fink

    IPC分类号： C07D213/64

    CPC分类号： C07D213/64

    摘要： A compound of the formula: ##STR1## where n is 1, 2, or 3;R.sub.3 is hydrogen or loweralkyl;R.sub.4 is hydrogen or loweralkyl; andAr is a phenyl group optionally mono-substituted with a loweralkoxy, halogen or trifluoromethyl group which are useful as intermediates.

    摘要翻译： 下式的化合物：其中n为1,2或3; R3是氢或低级烷基; R4是氢或低级烷基; 并且Ar是任选被用作中间体的低级烷氧基，卤素或三氟甲基单取代的苯基。