公开(公告)号：US20120289587A1

公开(公告)日：2012-11-15

申请号：US13553726

申请日：2012-07-19

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  David P.M. Pleynet ,  Soan Cheng ,  Jeffrey P. Whitten

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  David P.M. Pleynet ,  Soan Cheng ,  Jeffrey P. Whitten

IPC分类号： A61K31/381 ,  A61P13/12 ,  A61P27/02 ,  A61P1/16 ,  A61P11/00 ,  A61P19/02 ,  A61P17/06 ,  A61P1/00 ,  A61P9/00 ,  A61P17/00 ,  A61P21/00 ,  A61P11/02 ,  A61P15/02 ,  A61P19/10 ,  A61P37/06 ,  A61P3/10 ,  A61P37/00 ,  A61P21/04 ,  A61P7/06 ,  A61P11/06 ,  A61P25/00 ,  A61P29/00

CPC分类号： C07D333/68 ,  A61K31/00 ,  A61K31/405

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US20090137659A1

公开(公告)日：2009-05-28

申请号：US12192812

申请日：2008-08-15

申请人： Gonul VELICELEBI ,  Kenneth A. STAUDERMAN ,  David P.M. PLEYNET ,  Song CHENG ,  Jeffrey P. WHITTEN

发明人： Gonul VELICELEBI ,  Kenneth A. STAUDERMAN ,  David P.M. PLEYNET ,  Song CHENG ,  Jeffrey P. WHITTEN

IPC分类号： A61K31/381 ,  C12N5/06 ,  C07D409/12 ,  C07D333/36

CPC分类号： C07D333/68 ,  A61K31/00 ,  A61K31/405

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US07153875B2

公开(公告)日：2006-12-26

申请号：US10094142

申请日：2002-03-07

申请人： Magnus Pfahl ,  Catherine Tachdjian ,  Hussien A. Al-Shamma ,  Andrea Fanjul ,  David P.M. Pleynet ,  Lyle W. Spruce ,  Torsten R. Wiemann ,  Jason B. Ibarra

发明人： Magnus Pfahl ,  Catherine Tachdjian ,  Hussien A. Al-Shamma ,  Andrea Fanjul ,  David P.M. Pleynet ,  Lyle W. Spruce ,  Torsten R. Wiemann ,  Jason B. Ibarra

IPC分类号： C07D401/06 ,  A61K31/44

CPC分类号： C07D277/20 ,  C07D277/34 ,  C07D417/06 ,  C07D417/10 ,  C07D417/14

摘要： The invention relates to certain heterocyclic compounds useful for the treatment of cancer and other diseases, having the Formula (I): wherein: (a) m is an integer 0 or 1; (b) R12 is an alkyl, a substituted alkyl, a cycloalkyl, a substituted cycloalkyl, a heterocyclic, a substituted heterocyclic, a heteroaryl, a substituted heteroaryl, an aryl or a substituted aryl residue; (c) Ar3 is an aryl, a substituted aryl, a heteroaryl or a substituted heteroaryl residue; (d) Ar4 is an aryl, a substituted aryl, a heteroaryl or a substituted heteroaryl residue; (e) R5 is hydrogen, hydroxy, alkyl or substituted alkyl; (f) ----- represents a bond present or absent; and (g) W, X, Y and Z are independently or together —C(O)—, C(S), S, O, or NH; or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及可用于治疗癌症和其它疾病的某些杂环化合物，其具有式（I）：其中：（a）m为整数0或1; （b）R 12是烷基，取代的烷基，环烷基，取代的环烷基，杂环，取代的杂环，杂芳基，取代的杂芳基，芳基或取代的芳基; （c）Ar 3是芳基，取代的芳基，杂芳基或取代的杂芳基残基; （d）Ar 4是芳基，取代的芳基，杂芳基或取代的杂芳基残基; （e）R 5是氢，羟基，烷基或取代的烷基; （f）-----代表存在或不存在的债券; 和（g）W，X，Y和Z独立地或一起为-C（O） - ，C（S），S，O或NH; 或其药学上可接受的盐。