公开(公告)号：US20120289587A1

公开(公告)日：2012-11-15

申请号：US13553726

申请日：2012-07-19

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  David P.M. Pleynet ,  Soan Cheng ,  Jeffrey P. Whitten

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  David P.M. Pleynet ,  Soan Cheng ,  Jeffrey P. Whitten

IPC分类号： A61K31/381 ,  A61P13/12 ,  A61P27/02 ,  A61P1/16 ,  A61P11/00 ,  A61P19/02 ,  A61P17/06 ,  A61P1/00 ,  A61P9/00 ,  A61P17/00 ,  A61P21/00 ,  A61P11/02 ,  A61P15/02 ,  A61P19/10 ,  A61P37/06 ,  A61P3/10 ,  A61P37/00 ,  A61P21/04 ,  A61P7/06 ,  A61P11/06 ,  A61P25/00 ,  A61P29/00

CPC分类号： C07D333/68 ,  A61K31/00 ,  A61K31/405

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US08524765B2

公开(公告)日：2013-09-03

申请号：US13553726

申请日：2012-07-19

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  David P. M. Pleynet ,  Soan Cheng ,  Jeffrey P. Whitten

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  David P. M. Pleynet ,  Soan Cheng ,  Jeffrey P. Whitten

IPC分类号： A61K31/381 ,  C07D333/40

CPC分类号： C07D333/68 ,  A61K31/00 ,  A61K31/405

摘要： Described herein are compounds and pharmaceutical compositions containing compounds of Formula (I), which modulate the activity of store-operated calcium (SOC) channels: wherein R1, R2 and R4 are defined herein. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述了含有式（I）化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性：其中R1，R2和R4在本文中定义。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US08263641B2

公开(公告)日：2012-09-11

申请号：US12192812

申请日：2008-08-15

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  David P. M. Pleynet ,  Soan Cheng ,  Jeffrey P. Whitten

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  David P. M. Pleynet ,  Soan Cheng ,  Jeffrey P. Whitten

IPC分类号： A61K31/381 ,  C07D333/36

CPC分类号： C07D333/68 ,  A61K31/00 ,  A61K31/405

摘要： Described herein are compounds of Formula I and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also describe herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述了式I的化合物和含有这种化合物的药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US20130245025A1

公开(公告)日：2013-09-19

申请号：US13733795

申请日：2013-01-03

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： C07D333/38 ,  C07D471/04 ,  C07D417/12 ,  C07D409/12 ,  C07D495/04 ,  C07D413/12 ,  C07D491/048

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US20110166159A1

公开(公告)日：2011-07-07

申请号：US13050356

申请日：2011-03-17

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/497 ,  C07D409/04 ,  A61K31/381 ,  C07D401/04 ,  A61K31/4436 ,  C07D403/04 ,  A61K31/506 ,  A61K31/405 ,  A61K31/4184 ,  C07D417/14 ,  A61K31/428 ,  C07D401/14 ,  A61K31/4709 ,  A61K31/4155 ,  A61K31/4535 ,  A61P1/00 ,  A61P19/02 ,  A61P3/10 ,  A61P25/28 ,  A61P17/06 ,  A61P37/06 ,  A61P7/06

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US07906553B2

公开(公告)日：2011-03-15

申请号：US12548189

申请日：2009-08-26

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/38

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds of Formula (I) having the structure: where A, J, R1, R4, Z and X are described herein; and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述了具有以下结构的式（I）的化合物：其中A，J，R 1，R 4，Z和X在本文中描述; 和含有这种化合物的药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US20100261725A1

公开(公告)日：2010-10-14

申请号：US12548189

申请日：2009-08-26

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/498 ,  C07D263/54 ,  A61K31/423 ,  C07D471/04 ,  A61K31/437 ,  C07D491/048 ,  A61K31/4355 ,  C07D495/04 ,  A61K31/381 ,  C07D333/36 ,  C07D217/00 ,  A61K31/47 ,  C07D277/62 ,  A61K31/428 ,  C07D241/36 ,  C07D285/06 ,  A61K31/433 ,  A61P37/06 ,  A61P29/00

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US08372991B2

公开(公告)日：2013-02-12

申请号：US13050356

申请日：2011-03-17

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： C07D409/00

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds of Formula (I): wherein A, J, Z, X, R1 and R4 are defined herein, and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述的是式（I）的化合物：其中A，J，Z，X，R 1和R 4在本文中定义，以及含有这种化合物的药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US20110136816A1

公开(公告)日：2011-06-09

申请号：US13006701

申请日：2011-01-14

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/498 ,  A61K31/433 ,  A61K31/423 ,  A61K31/381 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4436 ,  A61K31/502 ,  A61P37/06 ,  A61P37/08 ,  A61P29/00 ,  A61P11/06 ,  A61P21/00 ,  A61P17/00 ,  A61P1/16

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US20130079348A1

公开(公告)日：2013-03-28

申请号：US13581984

申请日：2011-03-02

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： C07D409/12 ,  C07D417/12 ,  C07D333/38 ,  C07D471/04

CPC分类号： C07D409/12 ,  C07D333/38 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.