公开(公告)号：US20060281735A1

公开(公告)日：2006-12-14

申请号：US11405360

申请日：2006-04-17

Applicant: David Pickar ,  Torgny Svensson ,  Marie-Louise Wadenberg

Inventor： David Pickar ,  Torgny Svensson ,  Marie-Louise Wadenberg

IPC: A61K31/551 ,  A61K31/4178

CPC classification number: A61K31/4178 ,  A61K31/551 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides novel antipsychotic therapies and compositions useful therein and provides methods for identifying new candidate molecules for the treatment of psychosis based on the proportional binding affinities for α2 adrenergic and D2 dopamine receptors.

Abstract translation: 本发明提供了新颖的抗精神病药物治疗方法和其中可用的组合物，并且提供了基于α2肾上腺素能和D 2 N / SUB的比例结合亲和力鉴定用于治疗精神病的新候选分子的方法 >多巴胺受体。

公开(公告)号：US20220139517A1

公开(公告)日：2022-05-05

申请号：US17464814

申请日：2021-09-02

Applicant: Paul Duffy ,  Glenn Kazo ,  David Pickar ,  James Hunter

Inventor： Paul Duffy ,  Glenn Kazo ,  Michael Lusto ,  David Pickar ,  James Hunter

IPC: G16H20/10 ,  G16H40/67 ,  G16H10/40 ,  G16H10/60 ,  A61B5/00 ,  A61K31/5513 ,  G01N33/50

Abstract: A service to coordinate the care of patients who are on a REMS-required medication. The service implements a monitoring hub for coordinating the work between a clinician, pharmacy, and laboratory in the care of a patient. The patient has blood samples tested for safety monitoring. The monitoring hub performs the task of entering the test results . . . into the REMS database. The monitoring hub has qualified personnel who are enrolled in the REMS program as a prescriber designee for the clinician. The prescriber designee works with the clinician, pharmacy, or laboratory to ensure compliance with the REMS requirements. In addition to providing administrative support for REMS compliance, the service could be an integrated care management system that assists patients/families and providers with other aspects of their care and practice needs.

公开(公告)号：US5663167A

公开(公告)日：1997-09-02

申请号：US479039

申请日：1995-06-07

Applicant: David Pickar ,  Robert E. Litman ,  William Z. Potter

Inventor： David Pickar ,  Robert E. Litman ,  William Z. Potter

IPC: A61K31/415 ,  A61K31/445 ,  A61K31/475 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61K45/06

CPC classification number: A61K31/415 ,  A61K31/445 ,  A61K31/475 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61K45/06

Abstract: A method for treating a serious psychotic mental illness includes the step of administering to a patient in need of such treatment a combination of (i) an .alpha..sub.2 -adrenergic receptor antagonist and (ii) a D.sub.2 dopamine receptor antagonist. A pharmaceutical composition useful in the novel method includes an effective amount of the combination of the foregoing two ingredients together with a pharmaceutically acceptable carrier.

Abstract translation: 用于治疗严重精神病性精神疾病的方法包括向需要这种治疗的患者施用（i）α2-肾上腺素能受体拮抗剂和（ii）D2多巴胺受体拮抗剂的组合的步骤。 用于该新方法的药物组合物包括有效量的前述两种成分与药学上可接受的载体的组合。

公开(公告)号：US5492907A

公开(公告)日：1996-02-20

申请号：US987728

申请日：1992-12-09

Applicant: David Pickar ,  Robert E. Litman ,  William Z. Potter

Inventor： David Pickar ,  Robert E. Litman ,  William Z. Potter

IPC: A61K31/415 ,  A61K31/445 ,  A61K31/475 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61K45/06

CPC classification number: A61K45/06 ,  A61K31/415 ,  A61K31/445 ,  A61K31/475 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55

Abstract: A method for treating a serious psychotic mental illness includes the step of administering to a patient in need of such treatment a combination of (i) an .alpha..sub.2 -adrenergic receptor antagonist and (ii) a D.sub.2 dopamine receptor antagonist, A pharmaceutical composition useful in the novel method includes an effective amount of the combination of the foregoing two ingredients together with a pharmaceutically acceptable carrier.

Abstract translation: 用于治疗严重精神病性精神疾病的方法包括向需要这种治疗的患者施用以下组合的步骤：（i）α2-肾上腺素能受体拮抗剂和（ii）D2多巴胺受体拮抗剂，可用于 该新方法包括有效量的前述两种成分与药学上可接受的载体的组合。