公开(公告)号：US20120208789A1

公开(公告)日：2012-08-16

申请号：US13415415

申请日：2012-03-08

Applicant: Shalaby W. Shalaby ,  Joel T. Corbett ,  David R. Ingam ,  Michael A. Vaughn ,  James E. Shalaby

Inventor： Shalaby W. Shalaby ,  Joel T. Corbett ,  David R. Ingam ,  Michael A. Vaughn ,  James E. Shalaby

IPC: A61K31/65 ,  A61P31/00 ,  C08G18/72

CPC classification number: C08G18/73 ,  A61L24/0021 ,  A61L27/18 ,  A61L27/52 ,  A61L2430/06 ,  C08G18/12 ,  C08G18/3206 ,  C08G18/341 ,  C08G18/4244 ,  C08G18/428 ,  C08G18/4283 ,  C08G18/44 ,  C08G18/4887 ,  C08G64/0241 ,  C08G2230/00 ,  C08L75/04

Abstract: Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.

Abstract translation: 能够在生物环境中膨胀的可渗透，可吸收和不可吸收的脂肪族，分段聚氨酯和聚氨酯 - 尿素，其体积增加至少3％具有多于一种类型的链段，包括衍生自聚乙二醇和分子 链条在结构上被定制以允许使用相应的制剂和医疗装置作为生物活性剂的载体，基于氰基丙烯酸酯的组织粘合剂的流变改性剂，作为用于修复关节关节及其软骨的缺陷或患病组分的保护装置，以及用于软骨组织的支架 工程。

公开(公告)号：US20140046019A1

公开(公告)日：2014-02-13

申请号：US14058640

申请日：2013-10-21

Applicant: Shalaby W. Shalaby ,  Joel T. Corbett ,  David R. Ingam ,  Michael Aaron Vaughn

Inventor： Shalaby W. Shalaby ,  Joel T. Corbett ,  David R. Ingam ,  Michael Aaron Vaughn

IPC: C08G64/02

CPC classification number: C08G18/73 ,  A61L24/0021 ,  A61L27/18 ,  A61L27/52 ,  A61L2430/06 ,  C08G18/12 ,  C08G18/3206 ,  C08G18/341 ,  C08G18/4244 ,  C08G18/428 ,  C08G18/4283 ,  C08G18/44 ,  C08G18/4887 ,  C08G64/0241 ,  C08G2230/00 ,  C08L75/04

Abstract: Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.

Abstract translation: 能够在生物环境中膨胀的可渗透，可吸收和不可吸收的脂肪族，分段聚氨酯和聚氨酯 - 尿素，其体积增加至少3％具有多于一种类型的链段，包括衍生自聚乙二醇和分子 链条在结构上被定制以允许使用相应的制剂和医疗装置作为生物活性剂的载体，基于氰基丙烯酸酯的组织粘合剂的流变改性剂，作为用于修复关节关节及其软骨的缺陷或患病组分的保护装置，以及用于软骨组织的支架 工程。

公开(公告)号：US20090233887A1

公开(公告)日：2009-09-17

申请号：US12380391

申请日：2009-02-26

Applicant: Shalaby W. Shalaby ,  Joel T. Corbett ,  David R. Ingam ,  Michael Aaron Vaughn

Inventor： Shalaby W. Shalaby ,  Joel T. Corbett ,  David R. Ingam ,  Michael Aaron Vaughn

IPC: A61K31/65 ,  C08G18/00 ,  A61K47/34 ,  A61L24/04 ,  C08G77/04

CPC classification number: C08G18/73 ,  A61L24/0021 ,  A61L27/18 ,  A61L27/52 ,  A61L2430/06 ,  C08G18/12 ,  C08G18/3206 ,  C08G18/341 ,  C08G18/4244 ,  C08G18/428 ,  C08G18/4283 ,  C08G18/44 ,  C08G18/4887 ,  C08G64/0241 ,  C08G2230/00 ,  C08L75/04

Abstract: Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.

Abstract translation: 能够在生物环境中膨胀的可渗透，可吸收和不可吸收的脂肪族，分段聚氨酯和聚氨酯 - 尿素，其体积增加至少3％具有多于一种类型的链段，包括衍生自聚乙二醇和分子 链条在结构上被定制以允许使用相应的制剂和医疗装置作为生物活性剂的载体，基于氰基丙烯酸酯的组织粘合剂的流变改性剂，作为用于修复关节关节及其软骨的缺陷或患病组分的保护装置，以及用于软骨组织的支架 工程。