公开(公告)号：US20080185504A9

公开(公告)日：2008-08-07

申请号：US10776029

申请日：2004-02-10

Applicant: E. Lewis ,  David Strachan ,  Linda Kidder

Inventor： E. Lewis ,  David Strachan ,  Linda Kidder

IPC: H01J40/14

CPC classification number: G01N21/31 ,  G01N21/253

Abstract: Disclosed are pharmaceutical dosage unit manufacturing process control apparatus and methods. These can include acquiring a plurality of multi-pixel images of a flow of pharmaceutical dosage units at different wavelengths along an axis that is perpendicular to a direction of the flow of pharmaceutical dosage units, processing the images acquired in the step of acquiring, and providing an indication about the flow of pharmaceutical dosage units based on the step of processing.

Abstract translation: 公开了药物剂量单位制造过程控制装置和方法。 这些可以包括沿着垂直于药物剂量单位的流动方向的轴线获取不同波长的药物剂量单位流的多个多像素图像，处理在获取步骤中获取的图像并提供 关于基于加工步骤的药物剂量单位的流动的指示。

公开(公告)号：US20050199788A1

公开(公告)日：2005-09-15

申请号：US10776029

申请日：2004-02-10

Applicant: E. Lewis ,  David Strachan ,  Linda Kidder

Inventor： E. Lewis ,  David Strachan ,  Linda Kidder

IPC: G01N21/25 ,  G01N21/31 ,  H01J40/14

CPC classification number: G01N21/31 ,  G01N21/253

Abstract: Disclosed are pharmaceutical dosage unit manufacturing process control apparatus and methods. These can include acquiring a plurality of multi-pixel images of a flow of pharmaceutical dosage units at different wavelengths along an axis that is perpendicular to a direction of the flow of pharmaceutical dosage units, processing the images acquired in the step of acquiring, and providing an indication about the flow of pharmaceutical dosage units based on the step of processing.

Abstract translation: 公开了药物剂量单位制造过程控制装置和方法。 这些可以包括沿着垂直于药物剂量单位的流动方向的轴线获取不同波长的药物剂量单位流的多个多像素图像，处理在获取步骤中获取的图像并提供 关于基于加工步骤的药物剂量单位的流动的指示。

公开(公告)号：US20050140973A1

公开(公告)日：2005-06-30

申请号：US11007969

申请日：2004-12-09

Applicant: Harry Owen ,  David Strachan ,  Joseph Slater ,  James Tedesco

Inventor： Harry Owen ,  David Strachan ,  Joseph Slater ,  James Tedesco

IPC: G01J3/44 ,  G01N21/64 ,  G01N21/65

CPC classification number: G01N21/65 ,  G01J3/0291 ,  G01J3/44 ,  G01N21/645 ,  G01N2021/6484

Abstract: A compact Raman/fluorescence probe is capable of collecting spectra from a relatively large spot size as compared to tradition confocal Raman probes. The inventive probe collects spectra from an area of 1 mmm or greater, preferably 3-12 mm or more, compared to current instruments which utilize spot sizes on the order of 2-60 microns. The larger spot size facilitates the collection of statistically useful data from inhomogeneous and laser-sensitive samples, among other applications. Potential pharmaceutical applications include tablet dosage level measurements, as well as online and at-line quality-control (QC) monitoring opportunities. Other applications include tablet identification as a forensic tool to identify counterfeit pharmaceutical products; granulation and blend uniformity for improved formulation via better process understanding, and reactor cleanliness validation.

Abstract translation: 与传统的共焦拉曼探针相比，紧凑的拉曼/荧光探针能够从相对大的斑点尺寸收集光谱。 与使用大约2-60微米的光斑尺寸的现有仪器相比，本发明的探针从1mm或更大，优选3-12mm或更大的区域收集光谱。 较大的斑点尺寸有助于收集来自不均匀和激光敏感样品的统计学上有用的数据，以及其他应用。 潜在的药物应用包括片剂剂量水平测量，以及在线和在线质量控制（QC）监测机会。 其他应用包括将片剂鉴定作为识别假冒药品的法医工具; 制粒和混合均匀性，通过更好的工艺理解和反应堆清洁度验证改进配方。