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1.发明授权Antigens targeted by pathogenic AI4 T cells in type 1 diabetes and uses thereof 有权1型糖尿病中致病性AI4 T细胞靶向的抗原及其用途公开(公告)号：US08318670B2
公开(公告)日：2012-11-27
申请号：US11658457
申请日：2005-07-26
CPC分类号： C07K14/47
摘要： Provided are oligopeptide antigens to AI4-like T cells, and mouse proteins comprising those antigens. The oligopeptide antigens comprise the amino acid sequence XX(I/D/F/L)ENY(I/L)(E/W/Y)(L/M) or VMLENYTHL. Additionally provided are methods for treating a mammal having or at risk for type 1 diabetes using these antigens, or compounds which reduce or eliminate expression of these antigens. Kits comprising these antigens, and methods for determining whether a mammal is at risk for or has type 1 diabetes are also provided.
摘要翻译： 提供对于类似Aβ的T细胞的寡肽抗原，以及包含这些抗原的小鼠蛋白质。 寡肽抗原包含氨基酸序列XX（I / D / F / L）ENY（I / L）（E / W / Y）（L / M）或VMLENYTHL。 另外提供了使用这些抗原治疗患有或具有1型糖尿病风险的哺乳动物的方法，或减少或消除这些抗原表达的化合物。 还提供了包含这些抗原的试剂盒，以及用于确定哺乳动物是否处于或已经具有1型糖尿病的风险的方法。
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2.发明申请Antigens Targeted by Pathogenic T Cells in Type 1 Diabetes and Uses Thereof 审中-公开1型糖尿病中致病性T细胞靶向的抗原及其用途公开(公告)号：US20090137485A1
公开(公告)日：2009-05-28
申请号：US11886482
申请日：2006-03-09
CPC分类号： A61K39/0008 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2227/105 , A01K2267/0362 , A61K38/00 , C07K14/70539
摘要： Provided are polypeptides that are capable of binding a human HLA-A2 MHC class I molecule. Kits comprising these polypeptides in a container are also provided. Further provided are methods for determining whether a mammal is at risk for or has type 1 diabetes. Additionally provided are methods of preventing a CD8+ T cell that is cytotoxic to pancreatic islet β-cells from destroying a β-cell. Methods of treating a mammal that is at risk for type 1 diabetes are also provided, as are methods of treating a mammal that has type 1 diabetes.
摘要翻译： 提供能够结合人HLA-A2 MHC I类分子的多肽。 还提供了在容器中包含这些多肽的试剂盒。 还提供了用于确定哺乳动物是否处于或具有1型糖尿病的风险的方法。 另外提供了防止对胰岛β细胞具有细胞毒性的CD8 + T细胞破坏β细胞的方法。 还提供了治疗1型糖尿病风险的哺乳动物的方法，以及治疗具有1型糖尿病的哺乳动物的方法。
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3.发明申请Antigens Targeted by Pathogenic Al4 T Cells in Type 1 Diabetes and Uses Thereof 有权1型糖尿病中致病性Al4T细胞靶向的抗原及其用途公开(公告)号：US20100009923A1
公开(公告)日：2010-01-14
申请号：US11658457
申请日：2005-07-26
CPC分类号： C07K14/47
摘要： Provided are oligopeptide antigens to A14-like T cells, and mouse proteins comprising those antigens. The oligopeptide antigens comprise the amino acid sequence XX(I/D/F/L)ENY(I/L)(E/W/Y)(L/M) or VMLENYTHL. Additionally provided are methods for treating a mammal having or at risk for type 1 diabetes using these antigens, or compounds which reduce or eliminate expression of these antigens. Kits comprising these antigens, and methods for determining whether a mammal is at risk for or has type 1 diabetes are also provided.
摘要翻译： 提供对A14样T细胞的寡肽抗原，以及包含那些抗原的小鼠蛋白质。 寡肽抗原包含氨基酸序列XX（I / D / F / L）ENY（I / L）（E / W / Y）（L / M）或VMLENYTHL。 另外提供了使用这些抗原治疗患有或具有1型糖尿病风险的哺乳动物的方法，或减少或消除这些抗原表达的化合物。 还提供了包含这些抗原的试剂盒，以及用于确定哺乳动物是否处于或具有1型糖尿病风险的方法。
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