公开(公告)号：US20100017894A1

公开(公告)日：2010-01-21

申请号：US11922050

申请日：2006-06-13

申请人： Dirk Beher ,  Jonathan David Wrigley

发明人： Dirk Beher ,  Jonathan David Wrigley

IPC分类号： G01N33/00 ,  C12N15/63 ,  C12N5/10 ,  A01K67/00 ,  C12Q1/02

CPC分类号： C07K14/4711 ,  A01K2217/05 ,  A01K2267/0312 ,  C07K14/8114 ,  C12N15/8509

摘要： A modified amyloid precursor protein can be expressed from a DNA construct comprising an APP DNA sequence, or a fragment or artificial substrate thereof, encoding the mutation I45W, I45Y V46W or V46Y (numbering relative to A4CT); the use of the DNA construct in the generation of cell lines or transgenic animals and the use of these proteins or such transgenic animals in the diagnosis of Alzheimer's Disease and screening putative drugs against Alzheimer's Disease are also described.

摘要翻译： 修饰的淀粉样蛋白前体蛋白可以从包含APP DNA序列或其片段或人造底物的DNA构建体表达，编码突变I45W，I45Y V46W或V46Y（编号相对于A4CT）; 也描述了DNA构建体在产生细胞系或转基因动物中的用途以及这些蛋白质或这种转基因动物在诊断阿尔茨海默病和筛选针对阿尔茨海默病的推定药物中的用途。

公开(公告)号：US20060235187A1

公开(公告)日：2006-10-19

申请号：US11393227

申请日：2006-03-30

申请人： James McKenna ,  Edward de Brant Smith ,  David Wrigley

发明人： James McKenna ,  Edward de Brant Smith ,  David Wrigley

IPC分类号： C08G63/02

CPC分类号： C08G63/672 ,  C08L67/02 ,  C08L67/025 ,  C08L2666/18

摘要： Polyetherester elastomers comprising about 25 to about 59 weight percent poly(trimethylene ether) ester soft segments and about 41 to about 75 weight percent hard segments, wherein the poly(trimethylene ether) ester soft segments are derived from poly(trimethylene ether) glycol having a number average molecular weight of about 600 to about 2500. Compositions thereof and articles made therefrom are disclosed.

公开(公告)号：US06431221B1

公开(公告)日：2002-08-13

申请号：US09646879

申请日：2000-12-15

申请人： David Wrigley

发明人： David Wrigley

IPC分类号： D03D304

CPC分类号： D03D15/00 ,  D03D1/0094 ,  D03D3/04 ,  D03D15/0083 ,  D21F1/0054

摘要： A woven fabric comprises cross-machine direction weft yarns, and an array of interwoven warp yarns, the warp yarns being woven in the machine direction in alternating groups of relatively narrow yarns and relatively wide yarns. The narrow yarns are looped around a respective last weft yarn and backwoven, whilst the wider yarns are extended to form interdigitable loops for engagement of a pintle wire.

摘要翻译： 机织织物包括横机方向纬纱和交织经纱阵列，经纱在相对窄的纱线和相对较宽的纱线交替组合的机器方向上编织。 窄纱线围绕相应的最后一根纬纱缠绕，并且被缠绕，而较宽的纱线被延伸以形成用于接合线针的相互交错的回路。

公开(公告)号：US20080153817A1

公开(公告)日：2008-06-26

申请号：US10566844

申请日：2004-07-29

申请人： Dirk Beher ,  Michela Bettati ,  Graham David Checksfield ,  Ian Churcher ,  Victoria Alexandra Doughty ,  Paul Joseph Oakley ,  Abdul Quddus ,  Martin Richard Teall ,  Jonathan David Wrigley

发明人： Dirk Beher ,  Michela Bettati ,  Graham David Checksfield ,  Ian Churcher ,  Victoria Alexandra Doughty ,  Paul Joseph Oakley ,  Abdul Quddus ,  Martin Richard Teall ,  Jonathan David Wrigley

IPC分类号： A61K31/5377 ,  C07D209/82 ,  A61K31/403 ,  C07D295/00 ,  A61P25/28 ,  C07D209/96

CPC分类号： C07D401/04 ,  A61K31/403 ,  A61K31/4439 ,  C07D209/86 ,  C07D209/88 ,  C07D209/96 ,  C07D409/04

摘要： Compounds of formula (I): are useful in the treatment of diseases associated with deposition of β-amyloid in the brain.

摘要翻译： 式（I）化合物：可用于治疗与脑中β-淀粉样蛋白沉积相关的疾病。

公开(公告)号：US20060128235A1

公开(公告)日：2006-06-15

申请号：US11302779

申请日：2005-12-14

申请人： David Wrigley

发明人： David Wrigley

IPC分类号： B63H16/20

CPC分类号： B63H1/18

摘要： The present invention directly deals with the problem of cavitation corrosion by modifying the hub of a propeller to eliminate low pressure areas. The present invention is the placement, formation, and/or insertion, on a propeller, of a non-smooth area in each facet of the hub between each of the blades. This area is also sometimes referred to as the “blade root”. The exact configuration of the raised area can vary from a longitudinal raised area to single or multiple bumps or buttons to single or multiple pointed projections. By modifying the hub, whether by casting a new propeller with a redesigned hub, or by retrofitting an existing hub, the elimination of corrosion occurs when a high Developed Area Ratio (DAR) propeller hub has one or more raised protrusions on the surfaces of the propeller hub between each blade seat. The addition of the raised protrusions discourages the formation of low pressure areas around the hub. By removing the low pressure areas from the immediate area around the hub, the shock waves caused by the collapse of the low pressure areas is moved away from the propeller, thus eliminating corrosion impact damage.

摘要翻译： 本发明通过改进螺旋桨的轮毂来直接解决气穴腐蚀的问题，以消除低压区域。 本发明是在螺旋桨上布置，形成和/或插入在每个叶片之间的轮毂的每个小面上的非平滑区域。 这个区域有时也被称为“叶根”。 凸起区域的精确构造可以从纵向凸起区域到单个或多个凸起或按钮到单个或多个尖锐突出部变化。 通过修改轮毂，无论是通过重新设计的轮毂投入新的螺旋桨还是通过改装现有轮毂，当高开发面积比（DAR）螺旋桨轮毂在其表面上具有一个或多个凸起的突起时，会发生消除腐蚀 每个叶片座之间的螺旋桨毂。 升高的突起的添加阻止在轮毂周围形成低压区域。 通过从轮毂周围的直接区域移除低压区域，由低压区域的塌陷引起的冲击波从螺旋桨移开，从而消除腐蚀冲击损伤。

公开(公告)号：US5525230A

公开(公告)日：1996-06-11

申请号：US182162

申请日：1994-03-24

申请人： David Wrigley ,  Alan J. Smith

发明人： David Wrigley ,  Alan J. Smith

IPC分类号： C02F3/06 ,  C02F3/10 ,  C02F3/12 ,  C02F3/26

CPC分类号： C02F3/121 ,  C02F3/06 ,  C02F3/10 ,  C02F3/26 ,  Y02W10/15 ,  Y10S210/903

摘要： Apparatus (1) for treating a fluid, in this case wastewater, comprising a vessel or tank (2), a conduit (3) to supply the wastewater in an alternating sequence to the vessel (2), and a source (4) for oxygenating the bed of granular media (5) to provide aerated filter media. The filter bed is aerated during operation by air, oxygen enriched air or other gas being introduced at or adjacent the base (as viewed) of the bed through the source (4), which may be a perforated manifold, diffuser or the like extending substantially over the whole surface area of the bed (5). Also, the bed (5) is a granular media such as natural minerals or blast furnace slag media to the surface of the discrete particles of which is attached bacteria and microorganisms (a biomass) which effects treatment of the fluid. The influent at (3) derived from sewage is counter current to the air, and is particularly a non-nitrified influent namely wastewater that has previously been treated to reduce the BOD (biological oxygen demand) and suspended solids concentrations. The blast furnace slag media (5) has an average particle diameter of 2.8-4.0 mm and a porosity of 13.9%. In carrying out the process the periodic reversal of the flow through the filter bed maintains the concentration gradient of the microorganisms (biomass) substantially uniform as a desired concentration of microorganisms throughout the depth of the bed under all operating conditions in the embodiments illustrated. This provides for a uniform, efficient treatment of the sewage.

摘要翻译： PCT No.PCT / GB92 / 01323 Sec。 371日期1993年3月24日 102（e）1993年3月24日PCT提交1992年7月20日PCT公布。 出版物WO93 / 02970 日期：1993年2月18日。用于处理流体（在这种情况下为废水）的装置（1）包括容器或罐（2），用于以与废物（2）交替的顺序供应废水的管道（3） 以及用于对颗粒介质（5）的床进行氧化以提供充气的过滤介质的源（4）。 过滤床在操作期间通过空气充氧，富氧空气或其它气体通过源（4）引入床的底部（如图所示），其可以是穿孔歧管，扩散器等，基本上延伸 在床的整个表面区域（5）上。 此外，床（5）是诸如天然矿物质或高炉矿渣介质的颗粒介质，其离散颗粒的表面附着有影响流体处理的细菌和微生物（生物质）。 来自污水的（3）流入物与空气相反，特别是未经硝化的流入物，即先前已被处理以减少BOD（生物需氧量）和悬浮固体浓度的废水。 高炉矿渣介质（5）的平均粒径为2.8〜4.0mm，孔隙率为13.9％。 在进行该过程中，在所示实施例中，在所有操作条件下，通过过滤床的流动的周期性反转使微生物（生物质）的浓度梯度保持在所有操作条件下所有浓度的微生物在床的整个深度上基本均匀。 这规定了对污水进行统一，有效的处理。