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公开(公告)号：US20080153817A1
公开(公告)日：2008-06-26
申请号：US10566844
申请日：2004-07-29
申请人： Dirk Beher , Michela Bettati , Graham David Checksfield , Ian Churcher , Victoria Alexandra Doughty , Paul Joseph Oakley , Abdul Quddus , Martin Richard Teall , Jonathan David Wrigley
发明人： Dirk Beher , Michela Bettati , Graham David Checksfield , Ian Churcher , Victoria Alexandra Doughty , Paul Joseph Oakley , Abdul Quddus , Martin Richard Teall , Jonathan David Wrigley
IPC分类号： A61K31/5377 , C07D209/82 , A61K31/403 , C07D295/00 , A61P25/28 , C07D209/96
CPC分类号： C07D401/04 , A61K31/403 , A61K31/4439 , C07D209/86 , C07D209/88 , C07D209/96 , C07D409/04
摘要： Compounds of formula (I): are useful in the treatment of diseases associated with deposition of β-amyloid in the brain.
摘要翻译： 式（I）化合物：可用于治疗与脑中β-淀粉样蛋白沉积相关的疾病。
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2.发明授权(4, 5, 6, 7-tetrahydro-1-H-indol-7-yl) acetic acid derivatives for treatment of Alzheimer's disease 失效（4,5,6,7-四氢-1H-吲哚-7-基）乙酸衍生物，用于治疗阿尔茨海默病公开(公告)号：US07728022B2
公开(公告)日：2010-06-01
申请号：US11587779
申请日：2005-05-06
申请人： Michela Bettati , Ian Churcher , Victoria Alexandra Doughty , Timothy Harrison , Emmanuela Nizi , Adam Smith
发明人： Michela Bettati , Ian Churcher , Victoria Alexandra Doughty , Timothy Harrison , Emmanuela Nizi , Adam Smith
IPC分类号： A61K31/41 , A61K31/403 , C07D403/06 , C07D209/12
CPC分类号： C07D209/08 , C07D209/02 , C07D209/10 , C07D231/56 , C07D409/04
摘要： Compounds of formula I: are disclosed. The compounds are useful in treating or preventing diseases associated with deposition of Aβ in the brain.
摘要翻译： 公开了式I化合物。 该化合物可用于治疗或预防与A＆Bgr沉积相关的疾病; 在大脑中
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公开(公告)号：US07452899B2
公开(公告)日：2008-11-18
申请号：US10566486
申请日：2004-07-29
申请人： Michela Bettati , Amanda Louise Boase , Ian Churcher , Tamara Ladduwahetty , Kevin John Merchant , Abdul Quddus
发明人： Michela Bettati , Amanda Louise Boase , Ian Churcher , Tamara Ladduwahetty , Kevin John Merchant , Abdul Quddus
IPC分类号： A01N43/42 , A01N47/00 , A61K31/44 , A61K31/21 , A61K31/26 , A61K43/64 , C07D215/00 , C07D217/00
CPC分类号： C07D231/12 , C07D417/06
摘要： Compounds of Formula (I): inhibit the processing of APP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
摘要翻译： 式（I）的化合物：通过γ-分泌酶抑制APP的加工，因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号：US20060189666A1
公开(公告)日：2006-08-24
申请号：US10566486
申请日：2004-07-29
申请人： Michela Bettati , Amanda Boase , Ian Churcher , Tamara Ladduwahetty , Kevin Merchant , Abdul Quddus
发明人： Michela Bettati , Amanda Boase , Ian Churcher , Tamara Ladduwahetty , Kevin Merchant , Abdul Quddus
IPC分类号： A61K31/433 , C07D498/12
CPC分类号： C07D231/12 , C07D417/06
摘要： Compounds of Formula (I): inhibit the processing of APP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
摘要翻译： 式（I）的化合物：通过γ-分泌酶抑制APP的加工，因此可用于治疗或预防阿尔茨海默氏病。
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5.发明授权Pyrazole derivatives as gamma-secretase inhibitors useful in the treatment of Alzheimer's disease 失效吡唑衍生物作为可用于治疗阿尔茨海默病的γ-分泌酶抑制剂公开(公告)号：US07271191B2
公开(公告)日：2007-09-18
申请号：US10549226
申请日：2004-04-01
申请人： Michela Bettati , Mark Stuart Chambers , Peter Alan Hunt , Philip Jones , Angus Murray MacLeod , Helen Jane Szekeres , Martin Richard Teall
发明人： Michela Bettati , Mark Stuart Chambers , Peter Alan Hunt , Philip Jones , Angus Murray MacLeod , Helen Jane Szekeres , Martin Richard Teall
IPC分类号： A61K31/415 , C07D231/24 , C07D231/12
CPC分类号： C07D231/12 , C07D401/04 , C07D401/06 , C07D409/12
摘要： The compounds of formula I: inhibit gamma secretase and hence are of utility in the treatment or prevention of Alzheimer's Disease.
摘要翻译： 式I化合物：抑制γ-分泌酶，因此可用于治疗或预防阿尔茨海默氏病。
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6.发明申请(4, 5, 6, 7-Tetrahydro-1-H-Indol-7-Yl) Acetic Acid Derivatives for Treatment of Alzheimer's Disease 失效（4,5,6,7-四氢-1-H-吲哚-7-Y1）乙酸衍生物用于治疗阿尔茨海默病公开(公告)号：US20070232678A1
公开(公告)日：2007-10-04
申请号：US11587779
申请日：2005-05-06
申请人： Michela Bettati , Ian Churcher , Victoria Doughty , Timothy Harrison , Emanuela Nizi , Adam Smith
发明人： Michela Bettati , Ian Churcher , Victoria Doughty , Timothy Harrison , Emanuela Nizi , Adam Smith
IPC分类号： A61K31/403 , A61P25/28 , C07D209/02
CPC分类号： C07D209/08 , C07D209/02 , C07D209/10 , C07D231/56 , C07D409/04
摘要： Compounds of formula I: are disclosed. The compounds are useful in treating or preventing diseases associated with deposition of Aβ in the brain.
摘要翻译： 公开了式I化合物。 该化合物可用于治疗或预防与Aβ沉积相关的疾病。
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公开(公告)号：US20100009987A1
公开(公告)日：2010-01-14
申请号：US12302164
申请日：2007-06-01
IPC分类号： A61K31/5377 , C07D413/14 , C07D401/14 , A61K31/497 , A61P25/00
CPC分类号： A61K31/4439 , A61K31/51 , A61K31/5355
摘要： Compounds of formula (I): inhibit microtubule affinity regulating kinase (MARK) and therefore find use in treatment of neurodegenerative diseases associated with hyperphosphorylation of tau.
摘要翻译： 式（I）化合物：抑制微管亲和调节激酶（MARK），因此可用于治疗与tau的过度磷酸化有关的神经变性疾病。
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公开(公告)号：US20050165023A1
公开(公告)日：2005-07-28
申请号：US10512655
申请日：2003-05-01
申请人： Michela Bettati , Mark Chambers , Simon Goodacre , David Hallett , Michael Neil , Leslie Street
发明人： Michela Bettati , Mark Chambers , Simon Goodacre , David Hallett , Michael Neil , Leslie Street
IPC分类号： A61K31/53 , A61P1/08 , A61P1/14 , A61P13/10 , A61P15/00 , A61P21/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P27/16 , C07D487/04
CPC分类号： C07D487/04
摘要： A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a —NH— linkage, and substituted on the phenyl ring by one or two further substituents as defined herein, being selective ligands for GABAA receptors, in particular having good affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
摘要翻译： 一类7-苯基咪唑并[1,2-b] [1,2,4]三嗪衍生物，其在苯环的间位被任选取代的被氧原子连接或桥连的芳基或杂芳基取代 或-NH-键，并且在苯环上被一个或两个如本文所定义的其它取代基取代，是GABA A A受体的选择性配体，特别是对α2和/或α3具有良好的亲和力 和/或其α5亚基因此在治疗和/或预防中枢神经系统的不良状况（包括焦虑，惊厥和认知障碍）方面是有益的。
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9.发明申请Pyrazole derivatives as gamma-secretase inhibitors useful in the treatment of alzheimer's disease 失效吡唑衍生物作为可用于治疗阿尔茨海默病的γ-分泌酶抑制剂公开(公告)号：US20060264474A1
公开(公告)日：2006-11-23
申请号：US10549226
申请日：2004-04-01
申请人： Michela Bettati , Mark Chambers , Peter Hunt , Philip Jones , Angus MacLeod , Helen Szekeres , Martin Teall
发明人： Michela Bettati , Mark Chambers , Peter Hunt , Philip Jones , Angus MacLeod , Helen Szekeres , Martin Teall
IPC分类号： A61K31/4545 , A61K31/4439 , A61K31/4152 , C07D403/04
CPC分类号： C07D231/12 , C07D401/04 , C07D401/06 , C07D409/12
摘要： The compounds of formula (I): inhibit gamma-secretase and hence are of utility in the treatment or prevention of Alzheimer's disease.
摘要翻译： 式（I）化合物：抑制γ-分泌酶，因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号：US06936608B2
公开(公告)日：2005-08-30
申请号：US10416318
申请日：2001-11-08
申请人： Michela Bettati , Peter Blurton , William Robert Carling , Mark Stuart Chambers , David James Hallett , Andrew Jennings , Richard Thomas Lewis , Michael Geoffrey Neil Russell , Leslie Joseph Street , Helen Jane Szekeres , Monique Bodil Van Neil
发明人： Michela Bettati , Peter Blurton , William Robert Carling , Mark Stuart Chambers , David James Hallett , Andrew Jennings , Richard Thomas Lewis , Michael Geoffrey Neil Russell , Leslie Joseph Street , Helen Jane Szekeres , Monique Bodil Van Neil
CPC分类号： C07D487/04
摘要： A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a —NH— linkage, being selective ligands for GABAA receptors, in particular having good affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
摘要翻译： 一类7-苯基咪唑并[1,2-b] [1,2,4]三嗪衍生物，其在苯环的间位被任选取代的被氧原子连接或桥连的芳基或杂芳基取代 或-NH-连接，作为GABA A受体的选择性配体，特别是对α2和/或α3和/或α5亚基具有良好的亲和力，因此在治疗和/ 或预防中枢神经系统的不良状况，包括焦虑，抽搐和认知障碍。
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