公开(公告)号：US20200022880A1

公开(公告)日：2020-01-23

申请号：US16514539

申请日：2019-07-17

申请人： Nakia Dawn HALL

发明人： Nakia Dawn HALL

IPC分类号： A61J17/00

摘要： A pacifier assembly device comprising two pacifier components. The pacifier components are assembled together using a connection component. When assembled together, opposing nipple-like protrusions of each pacifier component assists an infant with successfully positioning one of the protrusions into its mouth. When disassembled, the pacifier components may each be used individually or thoroughly cleaned and sanitized.

公开(公告)号：US11596581B2

公开(公告)日：2023-03-07

申请号：US16514539

申请日：2019-07-17

申请人： Nakia Dawn Hall

发明人： Nakia Dawn Hall

IPC分类号： A61J17/00

摘要： A pacifier assembly device comprising two pacifier components. The pacifier components are assembled together using a connection component. When assembled together, opposing nipple-like protrusions of each pacifier component assists an infant with successfully positioning one of the protrusions into its mouth. When disassembled, the pacifier components may each be used individually or thoroughly cleaned and sanitized.

公开(公告)号：US20160040124A1

公开(公告)日：2016-02-11

申请号：US14775154

申请日：2014-03-13

申请人： Carrie L. BALLIET ,  James M. WAGNER ,  Shyamsundar SUBRAMANIAN ,  David PAJEROWSKI ,  Danilo CASIMIRO ,  Jessica FLYNN ,  Jennifer GALLI ,  Patrick MCHUGH ,  Dawn HALL ,  Christopher DANIELS ,  Jennifer GIRARD ,  MERCK SHARP & DOHME CORP.

发明人： James M. Wagner ,  Shyamsundar Subramanian ,  David Pajerowski ,  Danilo Casimiro ,  John Balliet (DECEASED) ,  Jessica Flynn ,  Jennifer Galli ,  Patrick McHugh ,  Dawn Hall ,  Christopher Daniels ,  Jennifer Girard

IPC分类号： C12N5/07 ,  C12P21/00 ,  C07K14/005 ,  C12N7/00

CPC分类号： C12N5/0601 ,  C07K14/005 ,  C12N7/00 ,  C12N2500/60 ,  C12N2511/00 ,  C12N2770/36151 ,  C12P21/00

摘要： The present invention relates to the use of increased culture pH, relative to standard insect cell culture conditions, during baculovirus infection of lepidopteran insect cells to enable production of recombinant chikungunya (CHIKV) virus like particles (VLPs). The invention further relates to adapted insect cell lines derived from insect cells such as Sf21, which can grow robustly at elevated culture pH, the use of said cell lines to recombinantly produce pH sensitive proteins in the correct conformation and increase expression of recombinant proteins relative to standard insect cell lines. In some embodiments of the invention, the cells are useful for recombinant production of CHIKV VLPs. The invention also relates to a method for the production of a pH-adapted lepidopteran insect cell line. In some embodiments of said method, the cell line is produced and/or maintained in reduced phosphate serum-free insect cell media.

摘要翻译： 本发明涉及在鳞翅目昆虫细胞杆状病毒感染期间相对于标准昆虫细胞培养条件增加培养物pH的用途，以使得能够生产重组基孔肯雅（CHIKV）病毒样颗粒（VLP）。 本发明还涉及衍生自昆虫细胞如Sf21的适应性昆虫细胞系，其可以在升高的培养pH下强壮生长，使用所述细胞系以正确构象重组产生pH敏感蛋白并增加重组蛋白相对于 标准昆虫细胞系。 在本发明的一些实施方案中，所述细胞可用于重组生产CHIKV VLP。 本发明还涉及一种用于生产pH适应的鳞翅目昆虫细胞系的方法。 在所述方法的一些实施方案中，产生和/或维持细胞系在减少的无磷酸血清无血清昆虫细胞培养基中。

公开(公告)号：US20120061430A1

公开(公告)日：2012-03-15

申请号：US12807855

申请日：2010-09-15

申请人： Kimberly Dawn Hall

发明人： Kimberly Dawn Hall

IPC分类号： A44C5/00

CPC分类号： A44C5/00 ,  A41D20/00 ,  A44C9/0092

摘要： The wrist cover/support for bracelets/watches is made of elastic fabric or comparable material. Once sewn or glued, this composition allows the invention to be placed over worn jewelry on wrist. Use of the wrist cover results in preventing jewelry loss, reduces likelihood of its damage, and also likely prevents jewelry from snagging, scratching or otherwise damaging items.

摘要翻译： 手镯/手表的腕套/支架由弹性织物或类似材料制成。 一旦缝合或胶合，该组合物允许将本发明放置在手腕上佩戴的首饰上。 使用腕套可以防止珠宝损失，减少其损坏的可能性，并且还可能防止珠宝阻塞，划伤或以其他方式损坏物品。