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1.发明授权Methods of upmodulating adaptive immune response using anti-PD-1 antibodies 失效使用抗PD-1抗体上调适应性免疫应答的方法公开(公告)号：US07521051B2
公开(公告)日：2009-04-21
申请号：US10540084
申请日：2003-12-22
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译： 本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。 所公开的组合物和方法可用于例如治疗自身免疫性疾病，炎性疾病，过敏，移植排斥，癌症和其它免疫系统疾病。
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公开(公告)号：US20080311117A1
公开(公告)日：2008-12-18
申请号：US11893989
申请日：2007-08-17
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译： 本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。 所公开的组合物和方法可用于例如治疗自身免疫性疾病，炎性疾病，过敏，移植排斥，癌症和其它免疫系统疾病。
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公开(公告)号：US20070258982A1
公开(公告)日：2007-11-08
申请号：US11707986
申请日：2007-02-20
IPC分类号： A61K39/395 , A61P1/00 , A61P1/18 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P31/18 , A61P43/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S514/861
摘要： The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22) and methods of using those antibodies, for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, septic shock, infectious disorders, transplant rejection, cancer, and other immune system disorders.
摘要翻译： 本申请提供了特异性结合人白细胞介素-22（IL-22）的人抗体及其抗原结合片段，以及使用这些抗体的方法，例如诊断，治疗或预防炎性疾病，自身免疫疾病，过敏症，败血症 休克，感染性疾病，移植排斥，癌症和其他免疫系统疾病。
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4.发明申请公开(公告)号：US20100028330A1
公开(公告)日：2010-02-04
申请号：US12405058
申请日：2009-03-16
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia-Valge Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia-Valge Archer , John Andrews , Caroline Russell
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译： 本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。 所公开的组合物和方法可用于例如治疗自身免疫性疾病，炎性疾病，过敏，移植排斥，癌症和其它免疫系统疾病。
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公开(公告)号：US08088905B2
公开(公告)日：2012-01-03
申请号：US12405058
申请日：2009-03-16
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Viia Valge-Archer , John Andrews , Caroline Russell
IPC分类号： C12N15/11
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译： 本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。 所公开的组合物和方法可用于例如治疗自身免疫性疾病，炎性疾病，过敏，移植排斥，癌症和其它免疫系统疾病。
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公开(公告)号：US07488802B2
公开(公告)日：2009-02-10
申请号：US10741481
申请日：2003-12-22
申请人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Vila Valge-Archer , John Andrews , Caroline Russell
发明人： Mary Collins , Clive R. Wood , Beatriz M. Carreno , Deborah Luxenberg , Jason Jussif , Laura L. Carter , Frances K. Bennett , Vila Valge-Archer , John Andrews , Caroline Russell
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译： 本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。 所公开的组合物和方法可以用于例如治疗自身免疫疾病，炎性疾病，过敏，移植排斥，癌症和其他免疫系统疾病。
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公开(公告)号：US20060210567A1
公开(公告)日：2006-09-21
申请号：US10540084
申请日：2003-12-22
申请人： Mary Collins , Clive Wood , Beatriz Carreno , Deborah Luxenberg , Jason Jussif , Laura Carter , Frances Bennett , Viia-Valge Archer , Caroline Russell
发明人： Mary Collins , Clive Wood , Beatriz Carreno , Deborah Luxenberg , Jason Jussif , Laura Carter , Frances Bennett , Viia-Valge Archer , Caroline Russell
CPC分类号： C07K16/2818 , A61K2039/505 , C07K16/2803 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译： 本公开提供可以作为PD-1（程序性死亡1）的激动剂和/或拮抗剂的抗体和抗原结合片段，从而调节一般的免疫应答，特别是由TcR和CD28介导的那些。 所公开的组合物和方法可用于例如治疗自身免疫性疾病，炎性疾病，过敏，移植排斥，癌症和其它免疫系统疾病。
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