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    Antibiotics
    1.
    发明授权
    Antibiotics 失效
    抗生素

    公开(公告)号：US4203973A

    公开(公告)日：1980-05-20

    申请号：US913304

    申请日：1978-06-07

    申请人： Martin Cole ,  John D. Hood ,  Dennis Butterworth

    发明人： Martin Cole ,  John D. Hood ,  Dennis Butterworth

    IPC分类号： C07D477/20 ,  A61K35/00

    CPC分类号： C07D477/20

    摘要： It has been found that an antibiotic can be obtained by the fermentation of certain strains of Streptomyces olivaceus and related organisms and when pure this antibiotic is an extremely potent inhibitor of many .beta.-lactamases. This antibiotic which we designate MM 4550A may be obtained in substantially pure form by the chromatographic purification of the crude antibacterial complex obtained from the culture medium.

    摘要翻译： 已经发现，通过某些菌株的橄榄油链霉菌和相关生物体的发酵可以获得抗生素，当纯的这种抗生素是许多β-内酰胺酶的非常有效的抑制剂时。 我们指定MM 4550A的抗生素可以通过从培养基中获得的粗抗菌复合物的色谱纯化以基本上纯的形式获得。

    Antibiotics
    4.
    发明授权
    Antibiotics 失效

    公开(公告)号：US4181716A

    公开(公告)日：1980-01-01

    申请号：US724947

    申请日：1976-09-20

    申请人： Martin Cole ,  John D. Hood ,  Dennis Butterworth

    发明人： Martin Cole ,  John D. Hood ,  Dennis Butterworth

    IPC分类号： C07D477/20 ,  A61K35/00

    CPC分类号： C07D477/20

    摘要： It has been found that an antibiotic can be obtained by the fermentation of certain strains of Streptomyces olivaceus and related organisms and when pure this antibiotic is an extremely potent inhibitor of many .beta.-lactamases. This antibiotic which we designate MM 4550A may be obtained in substantially pure form by the chromatographic purification of the crude antibacterial complex obtained from the culture medium.

    Antibiotics
    5.
    发明授权
    Antibiotics 失效
    抗生素

    公开(公告)号：US4172129A

    公开(公告)日：1979-10-23

    申请号：US717197

    申请日：1976-08-24

    申请人： Martin Cole ,  John D. Hood ,  Dennis Butterworth

    发明人： Martin Cole ,  John D. Hood ,  Dennis Butterworth

    IPC分类号： C07D477/20 ,  A61K35/00

    CPC分类号： C07D477/20 ,  Y10S435/902

    摘要： It has been found that an antibiotic can be obtained by the fermentation of certain strains of Streptomyces olivaceus and related organisms and when pure this antibiotic is an extremely potent inhibitor of many .beta.-lactamases. This antibiotic which we designate MM 4550A may be obtained in substantially pure form by the chromatographic purification of the crude antibacterial complex obtained from the culture medium.

    摘要翻译： 已经发现，通过某些菌株的橄榄油链霉菌和相关生物体的发酵可以获得抗生素，当纯的这种抗生素是许多β-内酰胺酶的非常有效的抑制剂时。 我们指定MM 4550A的抗生素可以通过从培养基中获得的粗抗菌复合物的色谱纯化以基本上纯的形式获得。