公开(公告)号：US08066690B2

公开(公告)日：2011-11-29

申请号：US12714874

申请日：2010-03-01

申请人： Dennis M. Vigil ,  Robert E. Reiss ,  Peter Barath

发明人： Dennis M. Vigil ,  Robert E. Reiss ,  Peter Barath

IPC分类号： A61M31/00

CPC分类号： A61M25/104 ,  A61M25/1002 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1086

摘要： A method for preventing a restenosis within a vessel wall requires a medicament be delivered at predetermined locations into the vessel wall and allowed to subsequently disperse in a predetermined pattern. To deliver the medicament, a catheter with an expanding member is advanced into the vasculature of a patient until the expanding member is located as desired. The expanding member is then expanded to force dispensers into the vessel wall to the proper depth. A medicament is then pumped through the dispensers to create a plurality of equally spaced, localized medicinal deliveries which subsequently disperse to medicate an annulus shaped volume within the vessel wall.

摘要翻译： 用于防止血管壁内的再狭窄的方法需要将药物在预定位置输送到血管壁中并允许随后以预定图案分散。 为了递送药物，具有扩张构件的导管被推进到患者的脉管系统中，直到根据需要定位扩张构件。 然后膨胀构件被膨胀以迫使分配器进入血管壁至适当的深度。 然后将药物泵送通过分配器以产生多个等间隔的局部药物输送，其随后分散以治疗血管壁内的环形体积。

公开(公告)号：US06425882B1

公开(公告)日：2002-07-30

申请号：US09847096

申请日：2001-05-01

申请人： Dennis M. Vigil

发明人： Dennis M. Vigil

IPC分类号： A61M2900

CPC分类号： A61M25/1038 ,  A61M25/10 ,  A61M25/1036 ,  A61M2025/1004

摘要： A device for folding a balloon of a balloon catheter during balloon deflation includes a band and a plurality of elongated fingers that are attached to the band. The band is formed with a tab and a notch and the length of the band corresponds to the diameter of the catheter tube. The band is folded into an annulus to interlock the tab with the notch. The annulus is attached to the catheter tube of the balloon catheter with the fingers extending over the balloon in a substantially same axial direction. In operation, the fingers are moveable between an unstressed configuration, when the balloon is deflated, and a stressed configuration, when the balloon is inflated. In a stressed configuration, the fingers urge against the balloon and are biased toward the stressed configuration to return to an unstressed configuration.

摘要翻译： 在球囊放气期间用于折叠气囊导管的球囊的装置包括附接到带的带和多个细长指状物。 带形成有突片和凹口，带的长度对应于导管的直径。 将带折叠成环形以将突片与凹口互锁。 环形物被附接到气囊导管的导管上，其中手指在大致相同的轴向方向上延伸到球囊上。 在操作中，当气囊膨胀时，手指可在不受压力的构型之间移动，当气囊收缩时，手指能够被应力配置。 在应力配置中，手指推动抵靠气球并被偏压到受压配置以返回到不受应力的构型。

公开(公告)号：US07338463B2

公开(公告)日：2008-03-04

申请号：US10742166

申请日：2003-12-19

申请人： Dennis M. Vigil

发明人： Dennis M. Vigil

IPC分类号： A61B17/20

CPC分类号： A61B17/320725 ,  A61B2017/22061 ,  A61B2090/08021

摘要： A sheath is provided to protect a blade when the blade is mounted on a balloon catheter. In particular, this protection is provided while the balloon is deflated for maneuver of the catheter through the vasculature of a patient. The sheath itself is a tubular shaped member that is bifurcated into substantially symmetric halves. Further, the sheath forms a channel for protecting the blade when its halves are juxtaposed. An adhesive bonds both halves of the sheath to the surface of the balloon. When the balloon is deflated, its halves are juxtaposed to cover the blade in the protective channel. On the other hand, when the balloon is inflated, the expanded surface of the balloon pulls the opposed sheath halves that are bonded to it from each other, to thereby expose the blade.

摘要翻译： 当刀片安装在球囊导管上时，设置护套以保护刀片。 特别地，当气囊被放气以便通过患者的脉管系统操纵导管时，提供这种保护。 护套本身是管状构件，其分叉成大致对称的两半。 此外，当它的一半并置时，护套形成用于保护刀片的通道。 粘合剂将护套的两半粘合到气球的表面。 当气囊收缩时，其一半并置以覆盖保护通道中的叶片。 另一方面，当气球膨胀时，气球的膨胀表面将彼此接合的相对的护套半部拉出，从而使刀片暴露。

公开(公告)号：US06210392B1

公开(公告)日：2001-04-03

申请号：US09232392

申请日：1999-01-15

申请人： Dennis M. Vigil ,  Robert E. Reiss ,  Peter Barath

发明人： Dennis M. Vigil ,  Robert E. Reiss ,  Peter Barath

IPC分类号： A61M3100

CPC分类号： A61M25/1002 ,  A61M2025/105 ,  A61M2025/1086

摘要： A method and device for injecting fluid into a treatment area of a vessel wall is provided herein. A first version of the device includes an inflatable balloon mounted on a catheter and a plurality of dispensers extending outwardly and moving with the balloon. At least one fluid passageway connects each injector in fluid communication with a fluid source. During use of the device, the balloon is first positioned in a vessel proximate the treatment area. Next, the balloon is inflated to embed the dispensers into the vessel wall. Subsequently, the fluid from the fluid source is introduced into the fluid passageway and through the dispensers into the treatment area. A second version of the device includes a plurality of flexible tubes mounted between a multi-lumen catheter and a grommet. A push-pull wire is connected to the grommet and passed through a lumen of the multi-lumen catheter. The dispensers are mounted on each of the flexible tubes. During use, the device is first positioned in a vessel. The push-pull wire is then partially withdrawn forcing the grommet to advance towards the multi-lumen catheter. The advancing grommet forces the flexible tubes to bow outwardly, embedding the dispensers into the vessel wall.

摘要翻译： 本文提供了将流体注入血管壁的治疗区域的方法和装置。 装置的第一版本包括安装在导管上的可充气气囊和向外延伸并随气囊移动的多个分配器。 至少一个流体通道连接与流体源流体连通的每个喷射器。 在使用装置期间，气囊首先被定位在靠近处理区域的容器中。 接下来，将气囊充气以将分配器嵌入血管壁。 随后，将来自流体源的流体引入流体通道并通过分配器进入处理区域。 装置的第二版本包括安装在多腔导管和索环之间的多个柔性管。 推拉线连接到索环并通过多腔导管的内腔。 分配器安装在每个柔性管上。 在使用过程中，设备首先定位在容器中。 然后推拉线被部分地撤回，迫使索环前进到多腔导管。 推进的垫圈强制柔性管向外弯曲，将分配器嵌入容器壁中。

公开(公告)号：US5344401A

公开(公告)日：1994-09-06

申请号：US60441

申请日：1993-05-12

申请人： Herbert R. Radisch ,  Dennis M. Vigil

发明人： Herbert R. Radisch ,  Dennis M. Vigil

IPC分类号： A61M25/00 ,  A61M29/00 ,  A61M5/32

CPC分类号： A61M25/1027 ,  A61M2025/1031 ,  A61M2025/1075

摘要： A catheter balloon is provided for medical dilation procedures which is formed from a polymeric composite having an enhanced integrity. The balloon comprises an expandable central body and two tapered termini positioned at opposing ends of the body which are formed from a structural layer of continuous polymeric materials characterized as biaxially oriented in the body, but not in the tapered termini. A layer of an imide-containing polymer is provided external to the structural layer of the tapered termini to coat the termini and strengthen or otherwise enhance the integrity of the termini not having a biaxial orientation. The imide-containing polymer coating may further be continuously extended to the body of the balloon. The imide-containing polymer is applied to the structural layer of the balloon, in a liquid state and heat cured over time to produce a high-integrity coating.

摘要翻译： 为具有增强的完整性的聚合复合材料形成的用于医疗扩张程序的导管气囊被提供。 气囊包括可膨胀的中心体和位于主体的相对端处的两个锥形末端，其由连续聚合材料的结构层形成，其特征在于在体内双轴取向，但不在锥形末端。 含有酰亚胺的聚合物层设置在锥形末端的结构层的外部，以涂覆末端，并加强或以其它方式增强不具有双轴取向的末端的完整性。 含酰亚胺的聚合物涂层可以进一步连续地延伸到气囊的主体。 将含酰亚胺的聚合物以液态施加到气囊的结构层，并随时间加热固化以产生高完整性涂层。

公开(公告)号：US5320634A

公开(公告)日：1994-06-14

申请号：US870148

申请日：1992-04-17

申请人： Dennis M. Vigil ,  Peter Barath

发明人： Dennis M. Vigil ,  Peter Barath

IPC分类号： A61M25/00 ,  A61B17/00 ,  A61B17/22 ,  A61M29/02 ,  A61B17/32 ,  A61M25/10

CPC分类号： A61B17/320725 ,  A61B2017/22061 ,  A61M2025/1086 ,  A61M25/104

摘要： A stenotic dilitation device includes a plurality of elongated atherotomes with cutters embedded in a substrate mounted on the outer surface of a flexible balloon along predetermined crease lines. The atherotomes are aligned along the longitudinal axis of the catheter. The ends of the balloon are attached to a hollow catheter tube over fluid ports in the catheter which establish fluid communication between the catheter and the internal chamber of the balloon. Fluid flow into and out of the chamber will inflate and deflate the balloon. When the balloon is deflated, retraction of the atherotomes toward the longitudinal axis of the catheter causes the creases and lines to form flaps of the balloon membrane material between adjacent atherotomes. In such deflated configuration, the flaps, rather than the cutters of the atherotomes, contact the vessel wall as the device is manipulated into position adjacent a stenotic site. On inflation of the balloon at the stenotic site, the atherotomes are urged against the stenosis to incise the stenosis. The incisions relieve pressure in the wall of the vessel and thus enhance dilation of the vessel by the balloon. After dilation, the balloon is deflated and the device is removed.

摘要翻译： 狭窄扩张装置包括多个细长的动脉粥样硬化，其具有嵌入在沿着预定折痕线安装在柔性气囊的外表面上的基底中的切割器。 动脉切断头沿着导管的纵向轴线对齐。 气囊的端部连接到导管中的流体端口上的中空导管，其建立导管和气囊内腔之间的流体连通。 流入和流出腔室的流体将使气囊膨胀和放气。 当气囊放气时，动脉粥样硬化骨朝向导管的纵向轴线的缩回导致褶皱和线形成相邻动脉粥样硬化斑块之间的球囊膜材料的瓣。 在这种放气结构中，当装置被操纵到狭窄部位附近的位置时，瓣片而不是动脉粥样硬化刀的切割器接触血管壁。 在狭窄部位的气囊膨胀时，动脉粥样硬化症被迫反对狭窄以切开狭窄。 切口减轻了血管壁的压力，从而增强了血管的膨胀。 膨胀后，气囊放气并将装置取出。

公开(公告)号：US06695830B2

公开(公告)日：2004-02-24

申请号：US09778594

申请日：2001-02-07

申请人： Dennis M. Vigil ,  Robert E. Reiss ,  Peter Barath

发明人： Dennis M. Vigil ,  Robert E. Reiss ,  Peter Barath

IPC分类号： A61M3100

CPC分类号： A61M25/104 ,  A61M25/1002 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1086

摘要： A method for preventing a restenosis within a vessel wall requires a medicament be delivered at predetermined locations into the vessel wall and allowed to subsequently disperse in a predetermined pattern. To deliver the medicament, a catheter with an expanding member is advanced into the vasculature of a patient until the expanding member is located as desired. The expanding member is then expanded to force dispensers into the vessel wall to the proper depth. A medicament is then pumped through the dispensers to create a plurality of equally spaced, localized medicinal deliveries which subsequently disperse to medicate an annulus shaped volume within the vessel wall.

公开(公告)号：US06623451B2

公开(公告)日：2003-09-23

申请号：US10202361

申请日：2002-07-26

申请人： Dennis M. Vigil

发明人： Dennis M. Vigil

IPC分类号： A61M2900

CPC分类号： A61M25/1038 ,  A61M25/10 ,  A61M25/1036 ,  A61M2025/1004 ,  A61M2025/1093

摘要： A device for folding a balloon of a balloon catheter during balloon deflation includes a band and a plurality of elongated fingers that are attached to the band. The band includes a midsection and a pair of overlaps with each overlap extending from the midsection to a respective end of the band. The band is folded into an annulus wherein the overlaps are juxtaposed and can be joined together by soldering, welding or adhesive bonding. The annulus is attached to the catheter tube of the balloon catheter with the fingers extending over the balloon in a substantially same axial direction. In operation, the fingers are moveable between an unstressed configuration, when the balloon is deflated, and a stressed configuration, when the balloon is inflated. In a stressed configuration, the fingers urge against the balloon and are biased toward the stressed configuration to return to an unstressed configuration.

公开(公告)号：US5713863A

公开(公告)日：1998-02-03

申请号：US584310

申请日：1996-01-11

申请人： Dennis M. Vigil ,  Peter I. Barath

发明人： Dennis M. Vigil ,  Peter I. Barath

IPC分类号： A61M25/00 ,  A61F2/958 ,  A61M29/02 ,  A61M29/00

CPC分类号： A61M29/02 ,  A61M25/10 ,  A61M25/1002 ,  A61M2025/0057 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1086

摘要： A device for injecting medication into a vessel wall includes a plurality of flexible tubes mounted between a multi-lumen catheter and a grommet. A push-pull wire is connected to the grommet and passed through a lumen of the multi-lumen catheter. A plurality of injectors are mounted on each of the flexible tubes. During use, the device is first positioned in a vessel. The push-pull wire is then partially withdrawn forcing the grommet to advance towards the multi-lumen catheter. The advancing grommet forces the flexible tubes to bow outwardly, embedding the injectors into the vessel wall. A fluid medication is then introduced through the multi-lumen catheter, into the flexible tubes and out of the injectors for infusion into the vessel wall.

摘要翻译： 用于将药物注入血管壁的装置包括安装在多腔导管和索环之间的多个柔性管。 推拉线连接到索环并通过多腔导管的内腔。 多个喷射器安装在每个柔性管上。 在使用过程中，设备首先定位在容器中。 然后推拉线被部分地撤回，迫使索环前进到多腔导管。 前进的垫圈强制柔性管向外弯曲，将注射器嵌入血管壁。 然后将流体药物通过多腔导管引入柔性管中，并从注射器中引入注入血管壁。

公开(公告)号：US5681281A

公开(公告)日：1997-10-28

申请号：US541526

申请日：1995-10-10

申请人： Dennis M. Vigil ,  Peter Barath

发明人： Dennis M. Vigil ,  Peter Barath

IPC分类号： A61M25/00 ,  A61F2/958 ,  A61M29/02 ,  A61M29/00

CPC分类号： A61M25/1002 ,  A61M25/10 ,  A61M29/02 ,  A61M2025/105 ,  A61M2025/1086

摘要： A device for injecting medication into a vessel wall includes an inflatable balloon mounted on a catheter. Additionally, a plurality of tubular fluid passageways are longitudinally mounted on the balloon, and a plurality of injectors are mounted on each tubular passageway and in fluid communication therewith. During use of the device, the balloon is first positioned in a vessel. The balloon is then inflated to embed the injectors into the vessel wall. Next, a fluid medicament is introduced through each of the fluid passageways for further infusion through the passageways and through the injectors into the vessel wall.

摘要翻译： 用于将药物注射到血管壁中的装置包括安装在导管上的可充气球囊。 此外，多个管状流体通道纵向安装在气球上，并且多个喷射器安装在每个管状通道上并与其流体连通。 在使用装置期间，首先将气囊定位在容器中。 然后将气囊充气以将注射器嵌入血管壁。 接下来，流体药物通过每个流体通道引入，以进一步通过通道输注并通过注射器进入血管壁。