公开(公告)号：US20100152702A1

公开(公告)日：2010-06-17

申请号：US12714874

申请日：2010-03-01

申请人： Dennis M. VIGIL ,  Robert E. REISS ,  Peter BARATH

发明人： Dennis M. VIGIL ,  Robert E. REISS ,  Peter BARATH

IPC分类号： A61M25/10 ,  A61M25/00 ,  A61M25/09

CPC分类号： A61M25/104 ,  A61M25/1002 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1086

摘要： A method for preventing a restenosis within a vessel wall requires a medicament be delivered at predetermined locations into the vessel wall and allowed to subsequently disperse in a predetermined pattern. To deliver the medicament, a catheter with an expanding member is advanced into the vasculature of a patient until the expanding member is located as desired. The expanding member is then expanded to force dispensers into the vessel wall to the proper depth. A medicament is then pumped through the dispensers to create a plurality of equally spaced, localized medicinal deliveries which subsequently disperse to medicate an annulus shaped volume within the vessel wall.

摘要翻译： 用于防止血管壁内的再狭窄的方法需要将药物在预定位置输送到血管壁中并允许随后以预定图案分散。 为了递送药物，具有扩张构件的导管被推进到患者的脉管系统中，直到根据需要定位扩张构件。 然后膨胀构件被膨胀以迫使分配器进入血管壁至适当的深度。 然后将药物泵送通过分配器以产生多个等间隔的局部药物输送，其随后分散以治疗血管壁内的环形体积。

公开(公告)号：US6102904A

公开(公告)日：2000-08-15

申请号：US232156

申请日：1999-01-15

申请人： Dennis M. Vigil ,  Robert E. Reiss ,  Peter Barath

发明人： Dennis M. Vigil ,  Robert E. Reiss ,  Peter Barath

IPC分类号： A61F2/958 ,  A61M29/02 ,  A61M31/00

CPC分类号： A61M25/104 ,  A61M25/10 ,  A61M25/1002 ,  A61M2025/1013

摘要： A method and device for injecting fluid into a treatment area of a vessel wall is provided herein. A first version of the device includes an inflatable balloon mounted on a catheter and a plurality of dispensers extending outwardly and moving with the balloon. At least one fluid passageway connects each injector in fluid communication with a fluid source. During use of the device, the balloon is first positioned in a vessel proximate the treatment area. Next, the balloon is inflated to embed the dispensers into the vessel wall. Subsequently, the fluid from the fluid source is introduced into the fluid passageway and through the dispensers into the treatment area. A second version of the device includes a plurality of flexible tubes mounted between a multi-lumen catheter and a grommet. A push-pull wire is connected to the grommet and passed through a lumen of the multi-lumen catheter. The dispensers are mounted on each of the flexible tubes. During use, the device is first positioned in a vessel. The push-pull wire is then partially withdrawn forcing the grommet to advance towards the multi-lumen catheter. The advancing grommet forces the flexible tubes to bow outwardly, embedding the dispensers into the vessel wall.

摘要翻译： 本文提供了将流体注入血管壁的治疗区域的方法和装置。 装置的第一版本包括安装在导管上的可充气气囊和向外延伸并随气囊移动的多个分配器。 至少一个流体通道连接与流体源流体连通的每个喷射器。 在使用装置期间，气囊首先被定位在靠近处理区域的容器中。 接下来，将气囊充气以将分配器嵌入血管壁。 随后，将来自流体源的流体引入流体通道并通过分配器进入处理区域。 装置的第二版本包括安装在多腔导管和索环之间的多个柔性管。 推拉线连接到索环并通过多腔导管的内腔。 分配器安装在每个柔性管上。 在使用过程中，设备首先定位在容器中。 然后推拉线被部分地撤回，迫使索环前进到多腔导管。 推进的垫圈强制柔性管向外弯曲，将分配器嵌入容器壁中。

公开(公告)号：US5873852A

公开(公告)日：1999-02-23

申请号：US785825

申请日：1997-01-10

申请人： Dennis M Vigil ,  Robert E. Reiss ,  Peter Barath

发明人： Dennis M Vigil ,  Robert E. Reiss ,  Peter Barath

IPC分类号： A61F2/958 ,  A61M25/00 ,  A61M29/00 ,  A61M29/02 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61M25/104 ,  A61M25/10 ,  A61M25/1002 ,  A61M29/02 ,  A61M2025/0057 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M37/00

摘要： A method and device for injecting fluid into a treatment area of a vessel wall is provided herein. A first version of the device includes an inflatable balloon mounted on a catheter and a plurality of injectors extending outwardly and moving with the balloon. At least one fluid passageway connects each injector in fluid communication with a fluid source. During use of the device, the balloon is first positioned in a vessel proximate the treatment area. Next, the balloon is inflated to embed the injectors into the vessel wall. Subsequently, the fluid from the fluid source is introduced into the fluid passageway and through the injectors into the treatment area. A second version of the device includes a plurality of flexible tubes mounted between a multi-lumen catheter and a grommet. A push-pull wire is connected to the grommet and passed through a lumen of the multi-lumen catheter. The injectors are mounted on each of the flexible tubes. During use, the device is first positioned in a vessel. The push-pull wire is then partially withdrawn forcing the grommet to advance towards the multi-lumen catheter. The advancing grommet forces the flexible tubes to bow outwardly, embedding the injectors into the vessel wall.

摘要翻译： 本文提供了将流体注入血管壁的治疗区域的方法和装置。 装置的第一版本包括安装在导管上的可充气气囊和向外延伸并随气囊移动的多个喷射器。 至少一个流体通道连接与流体源流体连通的每个喷射器。 在使用装置期间，气囊首先被定位在靠近处理区域的容器中。 接下来，气囊被充气以将注射器嵌入血管壁。 随后，来自流体源的流体被引入到流体通道中并且通过喷射器被引入到处理区域中。 装置的第二版本包括安装在多腔导管和索环之间的多个柔性管。 推拉线连接到索环并通过多腔导管的内腔。 注射器安装在每个柔性管上。 在使用过程中，设备首先定位在容器中。 然后推拉线被部分地撤回，迫使索环前进到多腔导管。 前进的垫圈强制柔性管向外弯曲，将注射器嵌入血管壁。

公开(公告)号：US5746716A

公开(公告)日：1998-05-05

申请号：US500121

申请日：1995-07-10

申请人： Dennis M. Vigil ,  Peter Barath

发明人： Dennis M. Vigil ,  Peter Barath

IPC分类号： A61M25/00 ,  A61F2/958 ,  A61M29/02 ,  A61M29/00

CPC分类号： A61M25/1002 ,  A61M25/10 ,  A61M29/02 ,  A61M2025/105 ,  A61M2025/1086

摘要： A device for injecting medication into a vessel wall includes an inflatable balloon mounted on a catheter. Additionally, a tubular sleeve surrounds the balloon to create an infusion chamber between the sleeve and the balloon, and a plurality of injectors are mounted on the sleeve in fluid communication with the infusion chamber. During use of the device, the balloon is first positioned in a vessel and then inflated to embed the injectors into the vessel wall. Next, a fluid medicament is introduced into the infusion chamber for further infusion from the chamber and through the injectors into the vessel wall.

摘要翻译： 用于将药物注射到血管壁中的装置包括安装在导管上的可充气球囊。 此外，管状套管围绕气囊以在套筒和气囊之间产生浸泡室，并且多个喷射器安装在套筒上，与输液腔流体连通。 在使用装置期间，首先将球囊定位在容器中，然后充气以将注射器嵌入血管壁。 接下来，将流体药物引入到浸泡室中，用于从腔室进一步输注并通过注射器进入血管壁。

公开(公告)号：US07008436B2

公开(公告)日：2006-03-07

申请号：US09733563

申请日：2000-12-08

申请人： Peter Barath

发明人： Peter Barath

IPC分类号： A61B17/04

CPC分类号： A61B17/11 ,  A61B17/00491 ,  A61B17/0469 ,  A61B17/115 ,  A61B2017/1107 ,  A61B2017/1135

摘要： The present invention, which addresses the needs described above, resides in an apparatus and method for coupling vascular apertures to a blood supply vessel in a manner that minimizes the time and operator dependent inconsistency in performing vascular anastomoses. In the coronary setting, this concept is fast and can be applied to both conventional and minimally invasive operative techniques. In the preferred embodiment, the present invention relates to an apparatus and method for facilitating end-to-side vascular anastomoses procedure, whereby the present invention acts as a coupling apparatus between a first, blood supplying hollow organ, e.g. the LIMA, radial artery, or a saphenous vein and the side wall of second hollow organ, typically one of the major coronary arteries, such as the left coronary artery (LCA), right coronary artery (RCA) or the circumflex (CX).

公开(公告)号：US5681281A

公开(公告)日：1997-10-28

申请号：US541526

申请日：1995-10-10

申请人： Dennis M. Vigil ,  Peter Barath

发明人： Dennis M. Vigil ,  Peter Barath

IPC分类号： A61M25/00 ,  A61F2/958 ,  A61M29/02 ,  A61M29/00

CPC分类号： A61M25/1002 ,  A61M25/10 ,  A61M29/02 ,  A61M2025/105 ,  A61M2025/1086

摘要： A device for injecting medication into a vessel wall includes an inflatable balloon mounted on a catheter. Additionally, a plurality of tubular fluid passageways are longitudinally mounted on the balloon, and a plurality of injectors are mounted on each tubular passageway and in fluid communication therewith. During use of the device, the balloon is first positioned in a vessel. The balloon is then inflated to embed the injectors into the vessel wall. Next, a fluid medicament is introduced through each of the fluid passageways for further infusion through the passageways and through the injectors into the vessel wall.

摘要翻译： 用于将药物注射到血管壁中的装置包括安装在导管上的可充气球囊。 此外，多个管状流体通道纵向安装在气球上，并且多个喷射器安装在每个管状通道上并与其流体连通。 在使用装置期间，首先将气囊定位在容器中。 然后将气囊充气以将注射器嵌入血管壁。 接下来，流体药物通过每个流体通道引入，以进一步通过通道输注并通过注射器进入血管壁。

公开(公告)号：US5112305A

公开(公告)日：1992-05-12

申请号：US598405

申请日：1990-10-16

申请人： Peter Barath ,  Ferenc Denes

发明人： Peter Barath ,  Ferenc Denes

IPC分类号： A61K47/48 ,  A61L29/16 ,  A61M16/04 ,  A61M29/02

CPC分类号： A61M29/02 ,  A61K47/48992 ,  A61L29/16 ,  A61M16/0481 ,  A61L2300/422 ,  A61L2300/602 ,  A61M2025/105 ,  A61M2025/1086

摘要： The present invention discloses a method of treatment of an atherosclerotic blood vessel. Specifically, therapeutic agents are delivered by means of a specialized catheter system to the deeper layers of the vessel wall with only minimal interuption of the vessel endothelium. This system will allow high local concentrations of otherwise toxic agents directly at the site of an atherosclerotic plaque. This invention will hopefully reduce the incidence of late restenosis attributed to cellular hyperplasia or rethrombosis.

摘要翻译： 本发明公开了一种治疗动脉粥样硬化血管的方法。 具体地说，治疗剂通过专门的导管系统被输送到血管壁的较深层，只有血管内皮的最小的间隙。 该系统将允许直接在动脉粥样硬化斑块部位的高浓度的其它毒性剂。 本发明希望可以降低归因于细胞增生或血栓形成的晚期再狭窄的发生率。

公开(公告)号：US08066690B2

公开(公告)日：2011-11-29

申请号：US12714874

申请日：2010-03-01

申请人： Dennis M. Vigil ,  Robert E. Reiss ,  Peter Barath

发明人： Dennis M. Vigil ,  Robert E. Reiss ,  Peter Barath

IPC分类号： A61M31/00

CPC分类号： A61M25/104 ,  A61M25/1002 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1086

摘要： A method for preventing a restenosis within a vessel wall requires a medicament be delivered at predetermined locations into the vessel wall and allowed to subsequently disperse in a predetermined pattern. To deliver the medicament, a catheter with an expanding member is advanced into the vasculature of a patient until the expanding member is located as desired. The expanding member is then expanded to force dispensers into the vessel wall to the proper depth. A medicament is then pumped through the dispensers to create a plurality of equally spaced, localized medicinal deliveries which subsequently disperse to medicate an annulus shaped volume within the vessel wall.

摘要翻译： 用于防止血管壁内的再狭窄的方法需要将药物在预定位置输送到血管壁中并允许随后以预定图案分散。 为了递送药物，具有扩张构件的导管被推进到患者的脉管系统中，直到根据需要定位扩张构件。 然后膨胀构件被膨胀以迫使分配器进入血管壁至适当的深度。 然后将药物泵送通过分配器以产生多个等间隔的局部药物输送，其随后分散以治疗血管壁内的环形体积。

公开(公告)号：US20060217680A1

公开(公告)日：2006-09-28

申请号：US11087073

申请日：2005-03-22

申请人： Peter Barath

发明人： Peter Barath

IPC分类号： A61M31/00

CPC分类号： A61M25/0017 ,  A61M25/04 ,  A61M25/1011 ,  A61M2025/105

摘要： The present invention is directed to the treatment of various ailments associated with the prostate gland, including benign prostate hypertrophy (BPH), cancer and chronic inflammatory diseases. The present invention describes, inter alia, devices, methods and therapeutic agents for the treatment of prostatic ailments.

摘要翻译： 本发明涉及治疗与前列腺相关的各种疾病，包括良性前列腺肥大（BPH），癌症和慢性炎性疾病。 本发明尤其描述了用于治疗前列腺疾病的装置，方法和治疗剂。

公开(公告)号：US5797935A

公开(公告)日：1998-08-25

申请号：US721597

申请日：1996-09-26

申请人： Peter Barath

发明人： Peter Barath

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B17/3211 ,  A61F2/84 ,  A61M25/00 ,  A61M29/02

CPC分类号： A61B17/320725 ,  A61B2017/22061 ,  A61M25/104

摘要： A balloon activated force concentrator for use in cooperation with an inflatable angioplasty balloon includes at least one elongated flexible panel, an elongated cutting blade mounted on the outside surface of the elongated flexible panel, and an elastic circular band attached to each end of the elongated flexible panel for securing the elongated flexible panel to an angioplasty balloon. Use of this balloon activated force concentrator requires mounting the device on an inflatable angioplasty balloon by inserting the distal end of the angioplasty balloon through one of the circular bands. The balloon activated force concentrator is then advanced over the balloon until the second circular band reaches the distal end of the balloon. At that point, the elasticity of the circular bands straddle the balloon to retain the activated force concentrator securely against the outer surface of the angioplasty balloon.

摘要翻译： 用于与可充气血管成形术球囊配合使用的球囊激活力集中器包括至少一个细长柔性面板，安装在细长柔性面板的外表面上的细长切割刀片和附接到细长柔性板的每一端的弹性圆形带 用于将细长柔性板固定到血管成形术气囊的面板。 使用这种球囊激活力集中器需要通过将血管成形术气囊的远端插入通过其中一个圆形带来将该装置安装在充气的血管成形术球囊上。 气球激活的力集中器然后在气球上前进，直到第二个圆形带到达球囊的远端。 此时，圆形带的弹性跨过球囊，以将活化的力集中器固定在血管成形术气球的外表面上。