公开(公告)号：US08813654B2

公开(公告)日：2014-08-26

申请号：US13220875

申请日：2011-08-30

Applicant: Detlef Müller ,  Matthias Kwitniewski ,  Igor Geiger ,  Paul Gier ,  Heiko Mannsbarth

Inventor： Detlef Müller ,  Matthias Kwitniewski ,  Igor Geiger ,  Paul Gier ,  Heiko Mannsbarth

IPC: B61F5/52

CPC classification number: B61F3/14 ,  B61F5/52

Abstract: A running gear frame for a rail vehicle includes a central transverse beam, and two longitudinal beams connected together in a frame transverse direction via the transverse beam, wherein the transverse beam has at least a front web element, a rear web element and a transverse beam lower chord. The web elements run between the longitudinal beams in the frame transverse direction and in a frame height direction and are connected therewith and are arranged spaced apart in a frame longitudinal direction. The transverse beam lower chord extends on an underside of the transverse beam between the longitudinal beams and is connected with the web elements. Furthermore, the transverse beam lower chord extends beyond the front web element and/or the rear web element by at least 10% of the web element distance.

Abstract translation: 用于轨道车辆的行驶齿轮架包括中央横梁和通过横梁在框架横向方向上连接在一起的两个纵向梁，其中横梁至少具有前腹板元件，后腹板元件和横梁 较低的和弦 腹板元件在框架横向和框架高度方向上在纵向梁之间延伸并且与框架高度方向连接并且在框架纵向方向上间隔布置。 横梁下弦在纵向梁之间的横向梁的下侧上延伸并且与腹板元件连接。 此外，横梁下弦延伸超过前腹板元件和/或后腹板元件至少10％的腹板元件距离。

公开(公告)号：US20070148437A1

公开(公告)日：2007-06-28

申请号：US10578024

申请日：2004-10-22

Applicant: Detlef Müller-Schulte

Inventor： Detlef Müller-Schulte

IPC: A61K8/72 ,  B32B5/16 ,  C08K9/00

CPC classification number: B82Y5/00 ,  A61K9/0009 ,  A61K41/0028 ,  Y10T428/254 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/32

Abstract: The invention relates to biocompatible, thermosensitive polymers that can be heated, with the aid of a high-frequency magnetic alternating field, by encapsulating magnetic and/or metallic colloids or magnetic nanoparticles. As a result of the inductive heating of the polymer matrix, physical structure changes are triggered in the polymer matrix that lead to the bioactive substances encapsulated in the matrix being released within a short period of time. This “stimulus-response” principle is employed for the production of controllable drug depots, contrast-intensifying media for NMR diagnostics or manipulable micro-tools, as media for blocking blood vessels and as controllable porogens in the production of membranes.

Abstract translation: 本发明涉及通过包封磁性和/或金属胶体或磁性纳米颗粒而可借助于高频磁性交变场被加热的生物相容的热敏性聚合物。 作为聚合物基质的感应加热的结果，在聚合物基质中引发物理结构变化，导致在短时间内封装在基质中的生物活性物质被释放。 这种“刺激反应”原理用于生产可控药物库，用于NMR诊断的可对比增强培养基或可操作的微型工具，作为阻断血管的介质和在膜的生产中作为可控致孔剂。

公开(公告)号：US07047436B2

公开(公告)日：2006-05-16

申请号：US09888461

申请日：2001-06-25

Applicant: Sabine Sommer ,  Detlef Müller ,  Markus Feuser

Inventor： Sabine Sommer ,  Detlef Müller ,  Markus Feuser

IPC: G06F1/04

CPC classification number: H04L29/06 ,  H04L45/745

Abstract: A digital microelectronic circuit comprises a clocked data-processing unit (1) and a converting unit (2) which reads in data present at the output of the data-processing unit, performs a predetermined converting operation on the data and passes on the converted data. The converting unit is realized in an asynchronous logic circuit, such that the period of time for performing the converting operation is shorter than the shortest time interval to the next change of the data present at the output of the data-processing unit. In this way, fast, serial synchronous processes can be parallelized from the point of view of the slow synchronous system in synchronous systems which are slow relative thereto by using asynchronous logics, without a further high-frequency clock system being required.

Abstract translation: 数字微电子电路包括时钟数据处理单元（1）和转换单元（2），其读取存在于数据处理单元的输出端的数据，对数据执行预定的转换操作并传递转换的数据 。 转换单元在异步逻辑电路中实现，使得用于执行转换操作的时间段短于在数据处理单元的输出处存在的数据的下一个改变的最短时间间隔。 以这种方式，从同步系统的慢同步系统的观点来看，快速的串行同步过程可以通过使用异步逻辑相对慢的同步系统进行并行化，而不需要进一步的高频时钟系统。

公开(公告)号：US20070087385A1

公开(公告)日：2007-04-19

申请号：US10580733

申请日：2004-11-23

Applicant: Detlef Müller-Schulte

Inventor： Detlef Müller-Schulte

IPC: C12Q1/68 ,  G01N33/53 ,  G01N33/551

CPC classification number: G01N33/5434 ,  B82Y25/00 ,  H01F1/37

Abstract: The invention relates to spherical and magnetic silicagel particles which are provided with an increased surface by incorporating SiO2 colloids and produced by a method for inverse dispersion cross-linking of silica sols. The addition of certain metallic oxides to said silica sols and a subsequent tempering make it possible to obtain silicagel particles which exhibit increased nucleic acid binding properties and are used for separating a nucleic acid and isolating biomolecules.

Abstract translation: 本发明涉及通过掺入SiO 2胶体并通过硅溶胶的反向分散交联方法产生的球形和磁性硅胶颗粒，其提供了增加的表面。 向所述二氧化硅溶胶中加入某些金属氧化物和随后的回火使得可以获得显示增加的核酸结合性质并用于分离核酸并分离生物分子的硅胶颗粒。

公开(公告)号：US06826680B2

公开(公告)日：2004-11-30

申请号：US09888458

申请日：2001-06-25

Applicant: Detlef Müller

Inventor： Detlef Müller

IPC: G06F1500

CPC classification number: G06F9/30185 ,  G06F9/30072 ,  G06F9/30145

Abstract: In a microcontroller (100) the command decoder (15) has access to at least one memory (14). The command decoder may thus be adapted to decode at least one conditional command, while the result of decoding the conditional command is dependent on the contents of said memory (14). The microcontroller according to the invention thus provides the possibility of considerably reducing the programming effort so that both the system performance and the code density can be significantly increased with a small additional number of hardware components.

Abstract translation: 在微控制器（100）中，命令解码器（15）可访问至少一个存储器（14）。 因此，命令解码器可以适于解码至少一个条件命令，而解码条件命令的结果取决于所述存储器（14）的内容。 因此，根据本发明的微控制器提供了显着减少编程工作量的可能性，使得可以用少量附加数量的硬件组件来显着增加系统性能和代码密度。

公开(公告)号：US08939086B2

公开(公告)日：2015-01-27

申请号：US13416601

申请日：2012-03-09

Applicant: Detlef Müller ,  Matthias Kwitniewski ,  Igor Geiger ,  Paul Gier ,  Heiko Mannsbarth

Inventor： Detlef Müller ,  Matthias Kwitniewski ,  Igor Geiger ,  Paul Gier ,  Heiko Mannsbarth

IPC: B61C1/00 ,  B61C9/50 ,  B61F3/04

CPC classification number: B61C9/50 ,  B61F3/04

Abstract: A running gear for a rail vehicle, including a wheel unit, a motor unit and a running gear frame unit being supported on the wheel unit. The motor unit is connected to the wheel unit to drive the wheel unit. Further more, the motor unit is suspended to the running gear frame unit via a connecting device. The connecting device is transversally elastic to allow a relative transverse motion between the motor unit and the running gear frame unit. The connecting device has a transverse rigidity being sufficiently low such that a contribution of the motor unit to an inertial moment of the running gear frame unit about the height direction is reduced by at least 50%.

Abstract translation: 一种用于轨道车辆的行走装置，包括车轮单元，马达单元和行驶齿轮架单元，其被支撑在车轮单元上。 电机单元连接到车轮单元以驱动车轮单元。 此外，马达单元通过连接装置悬挂到行驶齿轮架单元。 连接装置是横向弹性的，以允许马达单元和运行齿轮架单元之间的相对横向运动。 连接装置的横向刚性足够低，使得马达单元对行进齿轮架单元的围绕高度方向的惯性力矩的贡献降低至少50％。

公开(公告)号：US20130202732A1

公开(公告)日：2013-08-08

申请号：US13364765

申请日：2012-02-02

Applicant: Ullrich Hennemann ,  Detlef Müller ,  Andreas Böhm

Inventor： Ullrich Hennemann ,  Detlef Müller ,  Andreas Böhm

IPC: B29C49/56

CPC classification number: B29C49/56 ,  B29C2049/563

Abstract: A tool closing system for plastic blow molding machines comprises a drive base plate, a front mold clamping plate and a rear mold clamping plate positioned between the front clamping plate and the base plate. The base plate, front clamping plate, and rear clamping plate are shiftably arranged on guides which are mounted on a carriage. A drive device is fastened to the base plate and comprises an extensible and retractable drive rod which is articulated to the rear clamping plate for force transmission without bending moment. Two substantially C-shaped or U-shaped frame elements are arranged side by side in parallel with the guides. Each have a substantially horizontally extending central web and two substantially vertically extending webs. A respective one of the two vertical webs is articulated to the base plate and the other vertical web is articulated to the front clamping plate.

Abstract translation: 用于塑料吹塑机的工具关闭系统包括位于前夹板和底板之间的驱动基板，前模夹紧板和后模夹紧板。 基板，前夹板和后夹板可移动地布置在安装在托架上的导向件上。 驱动装置固定在基板上，并包括可伸缩的驱动杆，该驱动杆铰接到后夹板上，用于无弯矩的力传递。 两个基本上C形或U形的框架元件并排布置成与引导件平行。 每个都具有基本水平延伸的中心腹板和两个基本垂直延伸的腹板。 两个垂直腹板中的相应一个铰接到基板，另一个垂直腹板铰接到前夹板。

公开(公告)号：US07919333B2

公开(公告)日：2011-04-05

申请号：US10580733

申请日：2004-11-23

Applicant: Detlef Müller-Schulte

Inventor： Detlef Müller-Schulte

IPC: G01N33/553 ,  G01N33/53

CPC classification number: G01N33/5434 ,  B82Y25/00 ,  H01F1/37

Abstract: The invention relates to spherical and magnetic silicagel particles which are provided with an increased surface by incorporating SiO2 colloids and produced by a method for inverse dispersion cross-linking of silica sols. The addition of certain metallic oxides to said silica sols and a subsequent tempering make it possible to obtain silicagel particles which exhibit increased nucleic acid binding properties and are used for separating a nucleic acid and isolating biomolecules.

Abstract translation: 本发明涉及通过引入SiO 2胶体并通过二氧化硅溶胶的反向分散交联方法产生的球形和磁性硅胶颗粒，其具有增加的表面。 向所述二氧化硅溶胶中加入某些金属氧化物和随后的回火使得可以获得显示增加的核酸结合性质并用于分离核酸并分离生物分子的硅胶颗粒。

公开(公告)号：US06204033B1

公开(公告)日：2001-03-20

申请号：US09011667

申请日：1998-06-25

Applicant: Detlef Müller-Schulte

Inventor： Detlef Müller-Schulte

IPC: C12N1106

CPC classification number: C08J3/14 ,  B03C1/01 ,  C07K16/26 ,  C08F261/04 ,  C08J3/16 ,  C08J2329/04 ,  C08K3/22 ,  C08K9/08 ,  C08L51/003 ,  G01N33/5434 ,  H01F1/44 ,  Y10S435/815 ,  Y10S530/815 ,  Y10S530/816 ,  C08L29/04

Abstract: Spherically shaped polyvinyl alcohol (PVAL) polymer particles are prepared encapsulating a magnetic colloid that provides the particles with magnetic properties for use in binding biomolecules. The particles have a size of 1-10 &mgr;m that makes them particularly suitable for use in cell separation/sorting, cleaning biosubstances in suspension and diagnostic assays. The particles are prepared by dispersing a magnetic colloid containing a magnetic material such as a ferromagnetic or superparamagnetic substance in an aqueous solution of polyvinyl alcohol containing reactive hydroxyl groups, adding the resultant mixture to an organic phase containing a mixture of at least two emulsifiers, and adding a water-soluble cross-linking agent such as a dialdehyde that reacts with the hydroxyl groups of polyvinyl alcohol to form the polymer particles. The emulsifiers are miscible in the polyvinyl alcohol solution, and at least one emulsifier is semi-hydrophilic and at least one emulsifier is lipophilic. The cross-linking agent may be used in combination with a water-soluble diamine. The polymer particles contain reactive hydroxyl groups and can be provided with spacer molecules to which biomolecules such as antibodies, peptides, proteins, enzymes, streptavidin, avidin, oligonucleotides, oligosaccharides or DNA can be coupled. Vinyl monomers having one or more functional groups such as carboxyl, hydroxyl, amino, aldehyde or oxirane may be grafted to the polymer particles by radical polymerization under the catalytic effect of cerium (IV).

Abstract translation: 制备球形聚乙烯醇（PVAL）聚合物颗粒，其包封磁性胶体，其为颗粒提供用于结合生物分子的磁性。 这些颗粒的大小为1-10μm，使得它们特别适用于细胞分离/分选，清洗生物悬浮液和诊断测定。 颗粒通过将含有磁性材料如铁磁性或超顺磁性物质的磁性胶体分散在含有反应性羟基的聚乙烯醇的水溶液中而制备，将所得混合物加入到含有至少两种乳化剂的混合物的有机相和 加入与聚乙烯醇的羟基反应形成聚合物颗粒的水溶性交联剂如二醛。 乳化剂可在聚乙烯醇溶液中混溶，并且至少一种乳化剂是半亲水性的，并且至少一种乳化剂是亲脂性的。 交联剂可以与水溶性二胺组合使用。 聚合物颗粒含有活性羟基并且可以提供间隔分子，生物分子例如抗体，肽，蛋白质，酶，链霉亲和素，抗生物素蛋白，寡核苷酸，寡糖或DNA可以偶联。 具有羧基，羟基，氨基，醛或环氧乙烷的一个或多个官能团的乙烯基单体可以在铈（IV）的催化作用下通过自由基聚合接枝到聚合物颗粒上。

公开(公告)号：US20120260817A1

公开(公告)日：2012-10-18

申请号：US13416601

申请日：2012-03-09

Applicant: Detlef Müller ,  Matthias Kwitniewski ,  Igor Geiger ,  Paul Gier ,  Heiko Mannsbarth

Inventor： Detlef Müller ,  Matthias Kwitniewski ,  Igor Geiger ,  Paul Gier ,  Heiko Mannsbarth

IPC: B61F5/50

CPC classification number: B61C9/50 ,  B61F3/04

Abstract: A running gear for a rail vehicle, including a wheel unit, a motor unit and a running gear frame unit being supported on the wheel unit. The motor unit is connected to the wheel unit to drive the wheel unit. Further more, the motor unit is suspended to the running gear frame unit via a connecting device. The connecting device is transversally elastic to allow a relative transverse motion between the motor unit and the running gear frame unit. The connecting device has a transverse rigidity being sufficiently low such that a contribution of the motor unit to an inertial moment of the running gear frame unit about the height direction is reduced by at least 50%.

Abstract translation: 一种用于轨道车辆的行走装置，包括车轮单元，马达单元和行驶齿轮架单元，其被支撑在车轮单元上。 电机单元连接到车轮单元以驱动车轮单元。 此外，马达单元通过连接装置悬挂到行驶齿轮架单元。 连接装置是横向弹性的，以允许马达单元和运行齿轮架单元之间的相对横向运动。 连接装置的横向刚性足够低，使得马达单元对行进齿轮架单元的围绕高度方向的惯性力矩的贡献降低至少50％。