公开(公告)号：US20090169481A1

公开(公告)日：2009-07-02

申请号：US12174439

申请日：2008-07-16

申请人： Dhakshanamurthy Thirumalai ,  Chin-I Lin ,  Shian-Jy Wang

发明人： Dhakshanamurthy Thirumalai ,  Chin-I Lin ,  Shian-Jy Wang

IPC分类号： A61K49/12 ,  C08G77/00

CPC分类号： C08G83/003 ,  A61K49/124

摘要： A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of SP-DZ-L)i)j or SP-DX-Z-L)i)j, wherein, S is cyclosilane moiety with j silicon oxygen residual groups, and j is not less than 2; P is and 1 is not less than 1; D is a C3-30 dendritic moiety having n oxygen residue, and n is not less than 3; X is C3-30 moiety having bi-functional groups; Z is a C3-20 moiety having a plurality of functional group; and L is a metal cation.

摘要翻译： 树突状聚合物和使用其的磁共振成像造影剂。 磁共振造影剂包括根据S
结构的结构的树枝状聚合物）i）j或S分子量XZL）i）j，其中S是具有j个硅氧残基的环硅烷部分，j是 不低于2; P为1，不小于1; D是具有n个氧残基的C3-30树枝状部分，n不小于3; X是具有双官能团的C3-30部分; Z是具有多个官能团的C3-20部分; L是金属阳离子。

公开(公告)号：US08303937B2

公开(公告)日：2012-11-06

申请号：US12174439

申请日：2008-07-16

申请人： Dhakshanamurthy Thirumalai ,  Chin-I Lin ,  Shian-Jy Wang

发明人： Dhakshanamurthy Thirumalai ,  Chin-I Lin ,  Shian-Jy Wang

IPC分类号： C08L73/00 ,  A61K9/00 ,  C07D407/00

CPC分类号： C08G83/003 ,  A61K49/124

摘要： A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of SP-DZ-L)i)j or SP-DX-Z-L)i)j, wherein, S is cyclosilane moiety with j silicon oxygen residual groups, and j is not less than 2; P is and l is not less than 1; D is a C3-30 dendritic moiety having n oxygen residue, and n is not less than 3; X is C3-30 moiety having bi-functional groups; Z is a C3-20 moiety having a plurality of functional group; and L is a metal cation.

摘要翻译： 树突状聚合物和使用其的磁共振成像造影剂。 磁共振造影剂包括根据SP-DZ-L）i）j或SP-DX-ZL）i）j的结构的树枝状聚合物，其中S是具有j个硅氧残基的环硅烷部分，j是 不低于2; P和l不小于1; D是具有n个氧残基的C3-30树枝状部分，n不小于3; X是具有双官能团的C3-30部分; Z是具有多个官能团的C3-20部分; L是金属阳离子。

公开(公告)号：US20090169480A1

公开(公告)日：2009-07-02

申请号：US12174431

申请日：2008-07-16

申请人： Dhakshanamurthy Thirumalai ,  Chin-I Lin ,  Shian-Jy Jassy Wang

发明人： Dhakshanamurthy Thirumalai ,  Chin-I Lin ,  Shian-Jy Jassy Wang

IPC分类号： A61K49/06

CPC分类号： A61K49/124

摘要： A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of wherein, P is CH2CH2O1, and 1 is not less than 1 and j is not less than 2; D is a C3-30 dendritic moiety having n oxygen residue, and n is not less than 3 and i is more than 1; X is C3-30 moiety having bi-functional groups; Z is independent and includes a C3-20 moiety having a plurality of functional group, wherein the functional groups are selected from a group consisting of carbonyl, carboxyl, amine, ester, amide, or chelate group, and Z respectively bonds with X by a group; and L is a metal cation.

摘要翻译： 树突状聚合物和使用其的磁共振成像造影剂。 磁共振造影剂包括根据其结构的树枝状聚合物，其中P是CH 2 CH 2 O 1，1不小于1，j不小于2; D是具有n个氧残基的C3-30树枝状部分，n不小于3且i大于1; X是具有双官能团的C3-30部分; Z是独立的，并且包括具有多个官能团的C 3-20部分，其中所述官能团选自羰基，羧基，胺，酯，酰胺或螯合基团，Z分别与X键合 组; L是金属阳离子。