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1.发明申请PHENOTHIAZINE DERIVATIVE HAVING A DOUBLE BOND, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A PHARMACEUTICAL 有权具有双键的苯并噻嗪衍生物，其生产方法及其作为药物的用途公开(公告)号：US20100261643A1
公开(公告)日：2010-10-14
申请号：US12724520
申请日：2010-03-16
申请人： Stefanie KEIL , Elisabeth DEFOSSA , Dieter SCHMOLL , Axel DIETRICH , Johanna KUHLMANN-GOTTKE , Karl-Christian ENGEL
发明人： Stefanie KEIL , Elisabeth DEFOSSA , Dieter SCHMOLL , Axel DIETRICH , Johanna KUHLMANN-GOTTKE , Karl-Christian ENGEL
IPC分类号： A61K31/545 , A61K38/28 , A61K38/27 , A61K31/397 , C07D417/12 , C07D417/14 , A61P3/00 , A61P3/10 , A61P25/18 , A61P25/28 , A61P25/30 , A61P25/00
CPC分类号： C07D417/12 , C07D513/04
摘要： The present invention relates to substituted phenothiazines with a double bond and physiologically acceptable salts thereof, and their use as a medicament.
摘要翻译： 本发明涉及具有双键的取代吩噻嗪及其生理上可接受的盐，以及它们作为药物的用途。
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2.发明申请Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments 有权环烷基取代的7-氨基-4-喹诺酮-3-羧酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US20050182087A1
公开(公告)日：2005-08-18
申请号：US11042770
申请日：2005-01-25
申请人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Dieter Schmoll , Andreas Herling , Karl-Ulrich Wendt , Sven Ruf
发明人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Dieter Schmoll , Andreas Herling , Karl-Ulrich Wendt , Sven Ruf
IPC分类号： A61K31/47 , A61K31/4745 , C07D215/36 , C07D471/02
CPC分类号： C07D471/04 , C07D215/36
摘要： Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments The invention relates to cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for the prevention and treatment of type 2 diabetes.
摘要翻译： 环烷基取代的7-氨基-4-喹诺酮-3-羧酸衍生物，其制备方法及其作为药物的用途本发明涉及环烷基取代的7-氨基-4-喹诺酮-3-羧酸衍生物和生理学上 耐受的盐及其生理功能衍生物。 本发明涉及其中基团具有所述含义的式I化合物及其生理上耐受的盐。 该化合物适用于例如用于预防和治疗2型糖尿病的药物。
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3.发明授权Phenothiazine derivative having a double bond, method for the production thereof, and use thereof as a pharmaceutical 有权具有双键的吩噻嗪衍生物，其制备方法及其作为药物的用途公开(公告)号：US08207146B2
公开(公告)日：2012-06-26
申请号：US12724520
申请日：2010-03-16
申请人： Stefanie Keil , Elisabeth Defossa , Dieter Schmoll , Axel Dietrich , Johanna Kuhlmann-Gottke , Karl-Christian Engel
发明人： Stefanie Keil , Elisabeth Defossa , Dieter Schmoll , Axel Dietrich , Johanna Kuhlmann-Gottke , Karl-Christian Engel
IPC分类号： A61K31/675 , C07D279/00
CPC分类号： C07D417/12 , C07D513/04
摘要： The present invention relates to substituted phenothiazines with a double bond and physiologically acceptable salts thereof, and their use as a medicament.
摘要翻译： 本发明涉及具有双键的取代吩噻嗪及其生理上可接受的盐，以及它们作为药物的用途。
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4.发明申请HETEROCYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS COMPRISING THESE COMPOUNDS, AND THE USE THEREOF 有权杂环化合物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20110183998A1
公开(公告)日：2011-07-28
申请号：US13002933
申请日：2009-07-07
申请人： Gerhard Zoller , Dieter Schmoll , Marco Mueller , Guido Haschke , Ingo Focken
发明人： Gerhard Zoller , Dieter Schmoll , Marco Mueller , Guido Haschke , Ingo Focken
IPC分类号： A61K31/506 , C07D213/69 , C07D237/16 , C07D401/12 , A61K31/44 , A61K31/50 , A61P3/10 , A61P3/06 , A61P3/04 , A61P3/00 , A61K31/497 , C07D241/18
CPC分类号： C07D213/69 , C07D237/16 , C07D319/06 , C07D405/12
摘要： Heterocyclic derivatives, processes for their preparation, medicaments comprising these compounds, and the use thereof. The invention relates to compounds of the formula I in which the radicals R1, R2, R3, R4, W, A, B, D, E, G, L, M, R, T and Y have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example for the treatment of the metabolic syndrome, insulin resistance, obesity and diabetes.
摘要翻译： 杂环衍生物，其制备方法，包含这些化合物的药物及其用途。 本发明涉及其中基团R 1，R 2，R 3，R 4，W，A，B，D，E，G，L，M，R，T和Y具有所述含义的式I化合物， 其生理学耐受的盐。 该化合物适用于例如治疗代谢综合征，胰岛素抵抗，肥胖和糖尿病。
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5.发明申请PHENOTHIAZIN DERIVATES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS PHARMACEUTICALS 有权苯丙胺衍生物，其生产方法及其作为药物的用途公开(公告)号：US20090325942A1
公开(公告)日：2009-12-31
申请号：US12507202
申请日：2009-07-22
申请人： Stefanie KEIL , Elisabeth DEFOSSA , Karl SCHOENAFINGER , Dieter SCHMOLL , Axel DIETRICH , Johanna KUHLMANN-GOTTKE , Karl-Christian ENGEL
发明人： Stefanie KEIL , Elisabeth DEFOSSA , Karl SCHOENAFINGER , Dieter SCHMOLL , Axel DIETRICH , Johanna KUHLMANN-GOTTKE , Karl-Christian ENGEL
IPC分类号： A61K31/5415 , C07D417/14 , A61P3/00 , A61P25/18 , A61P25/28 , A61P25/34 , A61P25/00 , A61P25/32 , A61P3/10
CPC分类号： C07D417/12 , C07D417/14 , C07D513/04
摘要： The invention relates to compounds of the formula 1, wherein R1, R2, R3, R4, R5, R6, R7, A and B are as defined herein, the pharmaceutical compositions and the uses as pharmaceuticals.
摘要翻译： 本发明涉及式1的化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，A和B如本文所定义，药物组合物和用作药物。
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6.发明授权Heterocyclically substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments 有权杂环取代的7-氨基-4-喹诺酮-3-羧酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07498341B2
公开(公告)日：2009-03-03
申请号：US11042589
申请日：2005-01-25
申请人： Elisabeth Defossa , Dieter Kadereit , Sven Ruf , Thomas Klabunde , Dieter Schmoll , Andreas Herling , Karl-Ulrich Wendt
发明人： Elisabeth Defossa , Dieter Kadereit , Sven Ruf , Thomas Klabunde , Dieter Schmoll , Andreas Herling , Karl-Ulrich Wendt
IPC分类号： A61K31/4375
CPC分类号： C07D215/56 , C07D401/12 , C07D417/12 , C07D471/04
摘要： The invention relates to heterocyclically substituted 7-amino-4-quinolone-3-carboxylic acid derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof.The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for the prevention and treatment of type 2 diabetes.
摘要翻译： 本发明涉及杂环取代的7-氨基-4-喹诺酮-3-羧酸衍生物及其生理上耐受的盐和生理功能衍生物。 本发明涉及其中基团具有所述含义的式I化合物及其生理上耐受的盐。 该化合物适用于例如用于预防和治疗2型糖尿病的药物。
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7.发明申请7-phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments 有权7-苯基氨基-4-喹诺酮-3-羧酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US20050182085A1
公开(公告)日：2005-08-18
申请号：US11042023
申请日：2005-01-25
申请人： Elisabeth Defossa , Dieter Kadereit , Sven Ruf , Thomas Klabunde , Dieter Schmoll , Andreas Herling , Karl-Ulrich Wendt
发明人： Elisabeth Defossa , Dieter Kadereit , Sven Ruf , Thomas Klabunde , Dieter Schmoll , Andreas Herling , Karl-Ulrich Wendt
IPC分类号： A61K31/4709 , A61K31/4745 , C07D215/36 , C07D471/02
CPC分类号： C07D215/56 , C07D401/06 , C07D471/04
摘要： 7-Phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments The invention relates to 7-phenylamino-4-quinolone-3-carboxylic acid derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for the prevention and treatment of type 2 diabetes.
摘要翻译： 7-苯基氨基-4-喹诺酮-3-羧酸衍生物，其制备方法及其作为药物的用途本发明涉及7-苯基氨基-4-喹诺酮-3-羧酸衍生物以及生理上耐受的盐和生理功能衍生物 其中。 本发明涉及其中基团具有所述含义的式I化合物及其生理上耐受的盐。 该化合物适用于例如用于预防和治疗2型糖尿病的药物。
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公开(公告)号：US6076800A
公开(公告)日：2000-06-20
申请号：US180023
申请日：1998-10-30
CPC分类号： F02M63/0045 , F02M47/025 , F02M47/027 , F02M63/0026 , F02M2200/704 , F02M2547/003
摘要： A valve for controlling fluids, in which the valve member is adjusted by means of an actuating piston, which, together with a piezoelectric actuator piston, encloses a pressure chamber. In addition, the actuator piston and an affiliated piezoelectric stack are disposed in parallel radially next to the actuating piston, wherein upon excitation of the piezoelectric stack or adjustment of the actuator piston, the actuating piston executes a motion counter to the adjusting movement, and with its valve member, opens a relief bore.
摘要翻译： PCT No.PCT / DE97 / 02709 Sec。 371日期：1998年10月30日 102（e）日期1998年10月30日PCT 1997年11月19日PCT PCT。 公开号WO98 / 40623 日期1998年9月17日用于控制流体的阀，其中阀构件通过致动活塞进行调节，该致动活塞与压电致动器活塞一起围绕压力室。 此外，致动器活塞和附属压电叠层被放置在致动活塞的旁边并排设置，其中当激发压电叠层或致动器活塞的调节时，致动活塞执行与调节运动相反的运动，并且与 其阀构件打开释放孔。
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9.发明授权Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof 有权杂环化合物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US08470841B2
公开(公告)日：2013-06-25
申请号：US13002933
申请日：2009-07-07
申请人： Gerhard Zoller , Dieter Schmoll , Marco Mueller , Guido Haschke , Ingo Focken
发明人： Gerhard Zoller , Dieter Schmoll , Marco Mueller , Guido Haschke , Ingo Focken
IPC分类号： A01N43/40 , A61K31/435
CPC分类号： C07D213/69 , C07D237/16 , C07D319/06 , C07D405/12
摘要： Heterocyclic derivatives, processes for their preparation, medicaments comprising these compounds, and the use thereof. The invention relates to compounds of the formula I in which the radicals R1, R2, R3, R4, W, A, B, D, E, G, L, M, R, T and Y have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example for the treatment of the metabolic syndrome, insulin resistance, obesity and diabetes.
摘要翻译： 杂环衍生物，其制备方法，包含这些化合物的药物及其用途。 本发明涉及其中基团R 1，R 2，R 3，R 4，W，A，B，D，E，G，L，M，R，T和Y具有所述含义的式I化合物， 其生理学耐受的盐。 该化合物适用于例如治疗代谢综合征，胰岛素抵抗，肥胖和糖尿病。
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10.发明授权Phenothiazin derivatives, method for the production thereof and use thereof as pharmaceuticals 有权吩噻嗪衍生物，其制备方法和作为药物的用途公开(公告)号：US07732440B2
公开(公告)日：2010-06-08
申请号：US12507202
申请日：2009-07-22
申请人： Stefanie Keil , Elisabeth Defossa , Karl Schoenafinger , Dieter Schmoll , Axel Deitrich , Johanna Kuhlmann-Gottke , Karl-Christian Engel
发明人： Stefanie Keil , Elisabeth Defossa , Karl Schoenafinger , Dieter Schmoll , Axel Deitrich , Johanna Kuhlmann-Gottke , Karl-Christian Engel
IPC分类号： C07D417/14 , A61K31/5415
CPC分类号： C07D417/12 , C07D417/14 , C07D513/04
摘要： The invention relates to compounds of the formula I, wherein R1, R2, R3, R4, R5, R6, R7, A and B are as defined herein, the pharmaceutical compositions and the uses as pharmaceuticals.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，A和B如本文所定义，药物组合物和用作药物。
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