公开(公告)号：US20050129612A1

公开(公告)日：2005-06-16

申请号：US11018331

申请日：2004-12-21

申请人： Robert Zaczek ,  Richard Olson ,  Dietmar Seiffert ,  Lorin Thompson

发明人： Robert Zaczek ,  Richard Olson ,  Dietmar Seiffert ,  Lorin Thompson

IPC分类号： A61K51/08 ,  A61K51/00

CPC分类号： A61K51/0468

摘要： This invention relates to a method of using radiolabelled and/or radiopharmaceutical small molecule inhibitors of beta-amyloid peptide production for the diagnosis of neurological and other disorders involving APP processing and beta-amyloid production. Furthermore, radiolabelled small molecule inhibitors identified by the methods of the present invention would be useful in the diagnosis of neurological disorders, such as Alzheimer's disease, which involve elevated levels of Aβ peptides.

摘要翻译： 本发明涉及使用放射性标记的和/或放射性药物的β-淀粉样蛋白肽生产的小分子抑制剂用于诊断涉及APP处理和β-淀粉样蛋白生成的神经和其他病症的方法。 此外，通过本发明的方法鉴定的放射性标记的小分子抑制剂可用于诊断涉及升高水平的Aβ肽的神经障碍，例如阿尔茨海默氏病。

公开(公告)号：US20050019255A1

公开(公告)日：2005-01-27

申请号：US10734031

申请日：2003-12-11

申请人： Robert Zaczek ,  Richard Olson ,  Dietmar Seiffert ,  Lorin Thompson

发明人： Robert Zaczek ,  Richard Olson ,  Dietmar Seiffert ,  Lorin Thompson

IPC分类号： A61K49/00 ,  G01N33/68 ,  A61K51/00 ,  G01N33/53 ,  G01N33/567

CPC分类号： G01N33/6896 ,  G01N2333/4709 ,  G01N2500/02 ,  G01N2500/20 ,  G01N2800/2821

摘要： This invention relates to a novel method of screening for inhibitors of beta-amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders involving APP processing and beta-amyloid production. This invention also relates to identifying macromolecules involved in APP processing and beta-amyloid production. Furthermore, inhibitors identified by the screening method of the present invention are useful in the treatment of neurological disorders, such as Alzheimer's disease, which involve elevated levels of Aβ peptides.

摘要翻译： 本发明涉及一种筛选β-淀粉样蛋白生成抑制剂的新方法，从而鉴定了诸如涉及APP加工和β-淀粉样蛋白生成的神经学和其它病症治疗剂的抑制剂。 本发明还涉及鉴定参与APP处理和β-淀粉样蛋白生成的大分子。 此外，通过本发明的筛选方法鉴定的抑制剂可用于治疗神经障碍，例如阿尔茨海默氏病，其涉及升高的Aβ肽水平。

公开(公告)号：US20060183771A1

公开(公告)日：2006-08-17

申请号：US11354777

申请日：2006-02-15

申请人： Dietmar Seiffert ,  Robert Knabb

发明人： Dietmar Seiffert ,  Robert Knabb

IPC分类号： A61K31/47

CPC分类号： A61K38/57 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a novel pharmaceutical combination for treating thromboembolic and/or inflammatory diseases, wherein the combination has: (a) a first therapeutic agent independently selected from the group consisting of a selective Factor VIIa inhibitor, a selective Factor XIa inhibitor, a combination of the selective Factor VIIa and XIa inhibitors, or pharmaceutically acceptable salt forms thereof; and (b) a second therapeutic agent comprising a selective plasma kallikrein inhibitor or a pharmaceutically acceptable salt form thereof. The instant invention is also directed to a method and composition suitable for treating thromboembolic and/or inflammatory diseases using the novel combinations.

摘要翻译： 本发明涉及用于治疗血栓栓塞和/或炎性疾病的新型药物组合，其中该组合具有：（a）第一治疗剂，其独立地选自选自因子VIIa抑制剂，选择性因子XIa抑制剂， 选择性因子VIIa和XIa抑制剂的组合或其药学上可接受的盐形式; 和（b）包含选择性血浆激肽释放酶抑制剂或其药学上可接受的盐形式的第二治疗剂。 本发明还涉及适用于使用新颖组合治疗血栓栓塞和/或炎性疾病的方法和组合物。