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1.发明申请Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging 审中-公开使用小分子放射性配体发现淀粉样蛋白β肽生产抑制剂和诊断成像公开(公告)号：US20050129612A1
公开(公告)日：2005-06-16
申请号：US11018331
申请日：2004-12-21
申请人： Robert Zaczek , Richard Olson , Dietmar Seiffert , Lorin Thompson
发明人： Robert Zaczek , Richard Olson , Dietmar Seiffert , Lorin Thompson
CPC分类号： A61K51/0468
摘要： This invention relates to a method of using radiolabelled and/or radiopharmaceutical small molecule inhibitors of beta-amyloid peptide production for the diagnosis of neurological and other disorders involving APP processing and beta-amyloid production. Furthermore, radiolabelled small molecule inhibitors identified by the methods of the present invention would be useful in the diagnosis of neurological disorders, such as Alzheimer's disease, which involve elevated levels of Aβ peptides.
摘要翻译： 本发明涉及使用放射性标记的和/或放射性药物的β-淀粉样蛋白肽生产的小分子抑制剂用于诊断涉及APP处理和β-淀粉样蛋白生成的神经和其他病症的方法。 此外，通过本发明的方法鉴定的放射性标记的小分子抑制剂可用于诊断涉及升高水平的Aβ肽的神经障碍，例如阿尔茨海默氏病。
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2.发明申请Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging 有权使用小分子放射性配体发现淀粉样蛋白β肽生产抑制剂和诊断成像公开(公告)号：US20050019255A1
公开(公告)日：2005-01-27
申请号：US10734031
申请日：2003-12-11
申请人： Robert Zaczek , Richard Olson , Dietmar Seiffert , Lorin Thompson
发明人： Robert Zaczek , Richard Olson , Dietmar Seiffert , Lorin Thompson
IPC分类号： A61K49/00 , G01N33/68 , A61K51/00 , G01N33/53 , G01N33/567
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2500/02 , G01N2500/20 , G01N2800/2821
摘要： This invention relates to a novel method of screening for inhibitors of beta-amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders involving APP processing and beta-amyloid production. This invention also relates to identifying macromolecules involved in APP processing and beta-amyloid production. Furthermore, inhibitors identified by the screening method of the present invention are useful in the treatment of neurological disorders, such as Alzheimer's disease, which involve elevated levels of Aβ peptides.
摘要翻译： 本发明涉及一种筛选β-淀粉样蛋白生成抑制剂的新方法，从而鉴定了诸如涉及APP加工和β-淀粉样蛋白生成的神经学和其它病症治疗剂的抑制剂。 本发明还涉及鉴定参与APP处理和β-淀粉样蛋白生成的大分子。 此外，通过本发明的筛选方法鉴定的抑制剂可用于治疗神经障碍，例如阿尔茨海默氏病，其涉及升高的Aβ肽水平。
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3.发明授权Blockade of neuronal m-channels as a therapeutic approach to the treatment of neurological disease 失效神经元m通道的阻断作为治疗神经系统疾病的治疗方法
公开(公告)号：US5750528A
公开(公告)日：1998-05-12
申请号：US384289
申请日：1995-02-01
申请人： Barry Stephen Brown , Simon Piers Aiken , Robert Zaczek , Paul Richard Hartig , Christopher Allan Teleha , Wendell Wilkie Wilkerson , Richard Alan Earl
发明人： Barry Stephen Brown , Simon Piers Aiken , Robert Zaczek , Paul Richard Hartig , Christopher Allan Teleha , Wendell Wilkie Wilkerson , Richard Alan Earl
IPC分类号： A61K31/00 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/498 , A61K31/517 , A61K31/50 , A61K31/38 , A61K31/445 , A61K31/505
CPC分类号： A61K31/517 , A61K31/00 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/498
摘要： Compounds which block neuronal M-channels are useful for treating conditions involving neurotransmitter deficiencies, traumatic brain injury, or the depressive phase of bipolar disorder. Compounds can be evaluated for utility in treating these conditions by determining whether they are capable of blocking neuronal M-channels.
摘要翻译： 阻断神经元M通道的化合物可用于治疗涉及神经递质缺乏症，创伤性脑损伤或双相障碍抑郁期的病症。 可以通过确定它们是否能够阻断神经元M通道来评价化合物在治疗这些病症中的效用。
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4.发明授权Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging 有权使用小分子放射性配体发现淀粉样蛋白β肽生产抑制剂和诊断成像公开(公告)号：US06737038B1
公开(公告)日：2004-05-18
申请号：US09573789
申请日：2000-05-17
IPC分类号： A61K4900
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2500/02 , G01N2500/20 , G01N2800/2821
摘要： This invention relates to a novel method of screening for inhibitors of beta-amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders involving APP processing and beta-amyloid production. This invention also relates to identifying macromolecules involved in APP processing and beta-amyloid production. Furthermore, inhibitors identified by the screening method of the present invention are useful in the treatment of neurological disorders, such as Alzheimer's disease, which involve elevated levels of A&bgr; peptides.
摘要翻译： 本发明涉及一种筛选β-淀粉样蛋白生成抑制剂的新方法，从而鉴定了诸如涉及APP加工和β-淀粉样蛋白生成的神经学和其它病症治疗剂的抑制剂。 本发明还涉及鉴定参与APP处理和β-淀粉样蛋白生成的大分子。 此外，通过本发明的筛选方法鉴定的抑制剂可用于治疗神经障碍，例如阿尔茨海默氏病，其涉及升高的Aβ肽水平。
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公开(公告)号：US06262081B1
公开(公告)日：2001-07-17
申请号：US09349906
申请日：1999-07-08
申请人： Robert Zaczek
发明人： Robert Zaczek
IPC分类号： A61K31445
CPC分类号： A61K45/06 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K2300/00
摘要： The invention relates to a method of treating neurological disorders associated with neurotransmitter deficit in a mammal comprising administering to the mammal a therapeutically effective amount of a combination of: (i) at least one neurotransmitter release enhancer, and (ii) at least one acetylcholinesterase inhibitor. The invention also relates to compositions and kits containing the same.
摘要翻译： 本发明涉及一种治疗与哺乳动物神经递质逆转相关的神经障碍的方法，包括向哺乳动物施用治疗有效量的组合：（i）至少一种神经递质释放增强剂和（ii）至少一种乙酰胆碱酯酶抑制剂 。 本发明还涉及含有其的组合物和试剂盒。
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6.发明授权Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging 有权使用小分子放射性配体发现淀粉样蛋白β肽生产抑制剂和诊断成像公开(公告)号：US07153491B2
公开(公告)日：2006-12-26
申请号：US10734031
申请日：2003-12-11
IPC分类号： A61K49/00
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2500/02 , G01N2500/20 , G01N2800/2821
摘要： This invention relates to a novel method of screening for inhibitors of beta-amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders involving APP processing and beta-amyloid production. This invention also relates to identifying macromolecules involved in APP processing and beta-amyloid production. Furthermore, inhibitors identified by the screening method of the present invention are useful in the treatment of neurological disorders, such as Alzheimer's disease, which involve elevated levels of Aβ peptides.
摘要翻译： 本发明涉及一种筛选β-淀粉样蛋白生成抑制剂的新方法，从而鉴定了诸如涉及APP加工和β-淀粉样蛋白生成的神经学和其它病症治疗剂的抑制剂。 本发明还涉及鉴定参与APP处理和β-淀粉样蛋白生成的大分子。 此外，通过本发明的筛选方法鉴定的抑制剂可用于治疗神经障碍，例如阿尔茨海默氏病，其涉及升高的Aβ肽水平。
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7.发明授权Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging 失效使用小分子放射性配体发现淀粉样蛋白β肽生产抑制剂和诊断成像公开(公告)号：US06878363B2
公开(公告)日：2005-04-12
申请号：US09859261
申请日：2001-05-17
CPC分类号： A61K51/0468
摘要： A method of using radiolabelled and/or radiopharmaceutical small molecule inhibitors of beta-amyloid peptide production for the diagnosis of neurological and other disorders involving APP processing and beta-amyloid production. Radiolabelled small molecule inhibitors identified by the methods of the present invention would be useful in the diagnosis of neurological disorders, such as Alzheimer's disease, which involve elevated levels of Aβ peptides.
摘要翻译： 使用放射性标记和/或放射性药物小分子抑制剂β-淀粉样蛋白肽生产的方法用于诊断涉及APP加工和β-淀粉样蛋白生成的神经和其他疾病。 通过本发明方法鉴定的放射性标记的小分子抑制剂可用于诊断涉及升高水平的Aβ肽的神经障碍，例如阿尔茨海默氏病。
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8.发明授权Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production 有权使用小分子放射性配体发现淀粉样蛋白-β肽生产的抑制剂公开(公告)号：US06331408B1
公开(公告)日：2001-12-18
申请号：US09438901
申请日：1999-11-12
IPC分类号： C12Q137
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2500/02 , G01N2500/20 , G01N2800/2821 , Y10S435/968
摘要： This invention relates to a novel method of screening for inhibitors of beta-amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders involving APP processing and beta-amyloid production. This invention also relates to identifying macromolecules involved in APP processing and beta-amyloid production. Furthermore, inhibitors identified by the screening method of the present invention are useful in the treatment of neurological disorders, such as Alzheimer's disease, which involve elevated levels of A&bgr; peptides.
摘要翻译： 本发明涉及一种筛选β-淀粉样蛋白生成抑制剂的新方法，从而鉴定了诸如涉及APP加工和β-淀粉样蛋白生成的神经学和其它病症治疗剂的抑制剂。 本发明还涉及鉴定参与APP处理和β-淀粉样蛋白生成的大分子。 此外，通过本发明的筛选方法鉴定的抑制剂可用于治疗神经障碍，例如阿尔茨海默氏病，其涉及升高的Aβ肽水平。
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