NMR imaging with paramagnetic polyvalent metal salts of
poly-(acid-alkylene-amino)-alkanes
    2.
    发明授权
    NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes 失效
    聚(亚烷基 - 氨基) - 烷烃的顺磁多价金属盐的NMR成像

    公开(公告)号:US5039512A

    公开(公告)日:1991-08-13

    申请号:US057709

    申请日:1987-06-15

    摘要: In a method of imaging body tissue in a patient, comprising administering to the patient an effective amount of a pharmaceutical agent for effecting the relaxation times of atoms in body tissues undergoing NMR diagnosis, whereby image contrast is enhanced, said agent comprising an amount, effective to effect such relaxation times, of a paramagnetic, physiologically compatible salt of a physiologically compatible chelate complex of an ion of a lanthanide element of atomic numbers 57-70, or of a transition metal of atomic numbers 21-29, 42, or 44; and a pharmaceutically acceptable carrier, and subjecting the patient to NMR tomography, the improvement wherein said salt of said chelate complex is the calcium or magnesium salt. Such salts are new as are some of the complexing chelates.

    摘要翻译: 在患者体内成像身体组织的方法中,包括向患者施用有效量的用于进行经历核磁共振诊断的身体组织中的原子的松弛时间的药剂,由此增强图像对比度,所述药剂包含有效量 实现这样的松弛时间,原子序数为57-70的镧系元素离子的生理上相容的螯合络合物的顺磁性生理上相容的盐或原子序数21-29,42或44的过渡金属; 和药学上可接受的载体,并对患者进行NMR层析成像,其中所述螯合络合物的所述盐是钙盐或镁盐。 这些盐是一些新的络合螯合物。

    Composition of a n-carboxymethylated tetraazacyclododecane chelating
agent, a paramagnetic metal and excess calcium ions for MRI
    3.
    发明授权
    Composition of a n-carboxymethylated tetraazacyclododecane chelating agent, a paramagnetic metal and excess calcium ions for MRI 失效
    N-羧甲基化四氮杂环十二烷螯合剂,顺磁金属和过量钙离子的组成

    公开(公告)号:US5219553A

    公开(公告)日:1993-06-15

    申请号:US743212

    申请日:1991-08-09

    摘要: Magnetic resonance imaging contrast media used to affect the relaxation times of atoms in body tissues undergoing NMR diagnosis are disclosed. Such media comprise (1) a paramagnetic, physiologically compatible complex of (a) a chelant consisting of a N-carboxy methylated tetraazacyclododecane, and (b) a paramagnetic ion of a lanthanide element of atomic numbers 59-70, or of a transition metal of atomic numbers 21-29, 42 or 44, or a physiologically compatible salt of such a complex, and (2) a toxicity-reducing amount of labile calcium ions. The labile calcium ions can be derived from a source other than a salt of said chelant, e.g. an inorganic or organic calcium salt. NMR image-enhancing compositions comprising NMR image-enhancing effective amounts of said contrast media and pharmaceutically acceptable diluents are also disclosed.

    摘要翻译: 公开了用于影响经历NMR诊断的身体组织中的原子的弛豫时间的磁共振成像造影剂。 这种培养基包括(1)由(a)由N-羧基甲基化四氮杂环十二烷组成的螯合剂和(b)原子序数59-70的镧系元素的顺磁离子或过渡金属 的原子序数21-29,42或44,或这种络合物的生理上相容的盐,和(2)不稳定的钙离子的毒性减少量。 不稳定的钙离子可以衍生自除所述螯合剂的盐之外的来源,例如, 无机或有机钙盐。 还公开了包含NMR图像增强有效量的所述造影剂和药学上可接受的稀释剂的NMR图像增强组合物。