公开(公告)号：US08297454B2

公开(公告)日：2012-10-30

申请号：US12788930

申请日：2010-05-27

Applicant: Kay Uwe Kolshorn ,  Siegfreid Kobert ,  Dirk Behrens

Inventor： Kay Uwe Kolshorn ,  Siegfreid Kobert ,  Dirk Behrens

IPC: B61G5/04

CPC classification number: B61G5/04 ,  Y10T403/74

Abstract: An adapter coupler for adapting couplings of different design has a first connecting mechanism for the releasable connecting of the adapter coupler to a first coupling, a second connecting mechanism for the releasable connecting of the adapter coupler to a second coupling, and a coupler housing to connect the first connecting mechanism to the second connecting mechanism. With the objective of simplifying the manual manipulation of the adapter coupler, it is configured to be of lightweight construction, wherein the coupler housing is formed from fiber composite material, in particular carbon file composite material, and exhibits a shape adapted to an adapter coupler constructed from metal, and wherein the coupler housing exhibits a sturdy fiber architecture relative to the stress loads it experiences.

Abstract translation: 用于适应不同设计的联接器的适配器联接器具有用于将适配器联接器可释放地连接到第一联接器的第一连接机构，用于将适配器联接器可释放地连接到第二联接器的第二连接机构和用于连接的联接器壳体 第一连接机构到第二连接机构。 为了简化适配器耦合器的手动操作，其被配置为具有轻质结构，其中耦合器壳体由纤维复合材料特别是碳文件复合材料形成，并且呈现适于构造的适配器耦合器的形状 并且其中耦合器壳体相对于其经历的应力负载呈现出坚固的光纤结构。

公开(公告)号：US20110032029A1

公开(公告)日：2011-02-10

申请号：US12912336

申请日：2010-10-26

Applicant: Klaus J. OBERLAENDER ,  Ralph Haines ,  Eric Chesters ,  Dirk Behrens

Inventor： Klaus J. OBERLAENDER ,  Ralph Haines ,  Eric Chesters ,  Dirk Behrens

IPC: H01L25/00 ,  G06F9/44

CPC classification number: G06F17/5045

Abstract: A configurable processor architecture uses a common simulation database for multiple processor configurations to reduce the cost of producing customized processor configurations. An unchanging core portion is used in each processor configuration. To support different memory modules, identification signals are provided from the memory modules or an identification module to configure the core portion.

Abstract translation: 可配置的处理器架构使用多个处理器配置的通用模拟数据库来降低生产定制处理器配置的成本。 在每个处理器配置中使用不变的核心部分。 为了支持不同的存储器模块，从存储器模块或识别模块提供识别信号以配置核心部分。

公开(公告)号：US20100322706A1

公开(公告)日：2010-12-23

申请号：US12788930

申请日：2010-05-27

Applicant: Kay Uwe Kolshorn ,  Siegfried Kobert ,  Dirk Behrens

Inventor： Kay Uwe Kolshorn ,  Siegfried Kobert ,  Dirk Behrens

IPC: F16B1/00

CPC classification number: B61G5/04 ,  Y10T403/74

Abstract: An adapter coupler for adapting couplings of different design has a first connecting mechanism for the releasable connecting of the adapter coupler to a first coupling, a second connecting mechanism for the releasable connecting of the adapter coupler to a second coupling, and a coupler housing to connect the first connecting mechanism to the second connecting mechanism. With the objective of simplifying the manual manipulation of the adapter coupler, it is configured to be of lightweight construction, wherein the coupler housing is formed from fiber composite material, in particular carbon file composite material, and exhibits a shape adapted to an adapter coupler constructed from metal, and wherein the coupler housing exhibits a sturdy fiber architecture relative to the stress loads it experiences.

Abstract translation: 用于适应不同设计的联接器的适配器联接器具有用于将适配器联接器可释放地连接到第一联接器的第一连接机构，用于将适配器联接器可释放地连接到第二联接器的第二连接机构和用于连接的联接器壳体 第一连接机构到第二连接机构。 为了简化适配器耦合器的手动操作，其被配置为具有轻质结构，其中耦合器壳体由纤维复合材料特别是碳文件复合材料形成，并且呈现适于构造的适配器耦合器的形状 并且其中耦合器壳体相对于其经历的应力负载呈现出坚固的光纤结构。

公开(公告)号：US20070264277A1

公开(公告)日：2007-11-15

申请号：US11632319

申请日：2005-07-21

Applicant: Dirk Behrens ,  Elizabeth Bosch ,  Stephen Doberstein ,  Robert Halenbeck ,  Kevin Hestir ,  Min Huang ,  Ernestine Lee ,  Haishan Lin ,  Thomas Linnemann ,  Shannon Marshall ,  Justin Wong ,  Ge Wu ,  Aileen Zhou

Inventor： Dirk Behrens ,  Elizabeth Bosch ,  Stephen Doberstein ,  Robert Halenbeck ,  Kevin Hestir ,  Min Huang ,  Ernestine Lee ,  Haishan Lin ,  Thomas Linnemann ,  Shannon Marshall ,  Justin Wong ,  Ge Wu ,  Aileen Zhou

IPC: A61K39/00 ,  A61K38/00 ,  C07H21/00 ,  C07K14/00 ,  C07K16/18 ,  C12N15/00 ,  C12N15/87 ,  C12N5/06 ,  C12P1/00 ,  G01N33/53

CPC classification number: C07K16/243 ,  A61K38/00 ,  C07K14/53

Abstract: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.

Abstract translation: 公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。

公开(公告)号：US20050258517A1

公开(公告)日：2005-11-24

申请号：US10848997

申请日：2004-05-18

Applicant: Klaus Oberlaender ,  Ralph Haines ,  Eric Chesters ,  Dirk Behrens

Inventor： Klaus Oberlaender ,  Ralph Haines ,  Eric Chesters ,  Dirk Behrens

IPC: H01L23/495

CPC classification number: G06F17/5045

Abstract: A configurable processor architecture uses a common simulation database for multiple processor configurations to reduce the cost of producing customized processor configurations. An unchanging core portion is used in each processor configuration. To support different memory modules, identification signals are provided from the memory modules or an identification module to configure the core portion.

Abstract translation: 可配置的处理器架构使用多个处理器配置的通用模拟数据库来降低生产定制处理器配置的成本。 在每个处理器配置中使用不变的核心部分。 为了支持不同的存储器模块，从存储器模块或识别模块提供识别信号以配置核心部分。

公开(公告)号：US08575312B2

公开(公告)日：2013-11-05

申请号：US13446254

申请日：2012-04-13

Applicant: Dirk Behrens ,  Elizabeth Bosch ,  Stephen K. Doberstein ,  Robert Forgan Halenbeck ,  Kevin Hestir ,  Min Mei Huang ,  Ernestine Lee ,  Haishan Lin ,  Thomas Linnemann ,  Shannon Marshall ,  Justin G. P. Wong ,  Ge Wu ,  Aileen Zhou ,  Cindy Leo ,  Lewis T. Williams

Inventor： Dirk Behrens ,  Elizabeth Bosch ,  Stephen K. Doberstein ,  Robert Forgan Halenbeck ,  Kevin Hestir ,  Min Mei Huang ,  Ernestine Lee ,  Haishan Lin ,  Thomas Linnemann ,  Shannon Marshall ,  Justin G. P. Wong ,  Ge Wu ,  Aileen Zhou ,  Cindy Leo ,  Lewis T. Williams

IPC: C07K14/00

CPC classification number: C07K16/243 ,  A61K38/00 ,  C07K14/53

Abstract: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.

Abstract translation: 公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。

公开(公告)号：US07821849B2

公开(公告)日：2010-10-26

申请号：US12028302

申请日：2008-02-08

Applicant: Klaus J. Oberlaender ,  Ralph Haines ,  Eric Chesters ,  Dirk Behrens

Inventor： Klaus J. Oberlaender ,  Ralph Haines ,  Eric Chesters ,  Dirk Behrens

IPC: G11C7/10

CPC classification number: G06F17/5045

Abstract: A configurable processor architecture uses a common simulation database for multiple processor configurations to reduce the cost of producing customized processor configurations. An unchanging core portion is used in each processor configuration. To support different memory modules, identification signals are provided from the memory modules or an identification module to configure the core portion.

Abstract translation: 可配置的处理器架构使用多个处理器配置的通用模拟数据库来降低生产定制处理器配置的成本。 在每个处理器配置中使用不变的核心部分。 为了支持不同的存储器模块，从存储器模块或识别模块提供识别信号以配置核心部分。

公开(公告)号：US08596475B2

公开(公告)日：2013-12-03

申请号：US13099537

申请日：2011-05-03

Applicant: Siegfried Kobert ,  Kay Uwe Kolshorn ,  Dirk Behrens

Inventor： Siegfried Kobert ,  Kay Uwe Kolshorn ,  Dirk Behrens

IPC: B61G1/00

CPC classification number: B61G5/04

Abstract: An adapter coupler (1) for adapting couplings of different design, wherein the adapter coupler (1) comprises a first connecting mechanism for releasably connecting the adapter coupler (1) to a first coupling, a second connecting mechanism for releasably connecting the adapter coupler (1) to the drawhook (50) of a second coupling, and a coupler housing (2) for connecting the first connecting mechanism to the second connecting mechanism, and wherein the second connecting mechanism comprises a tension yoke (8) with which to engage with the drawhook (50) of the second coupling. The adapter coupler (1) having a mechanism for height centering, comprising a drawbar eye (14) connected to the coupler housing (2), wherein the drawbar eye (14) is arranged and configured relative the tension yoke (8) such that upon the adapter coupler (1) being inserted into the jaw of the drawhook (50) of the second coupling, the drawhook (50) can engage in one joint process with both the accommodation formed by the tension yoke (8) as well as with the drawbar eye (14).

Abstract translation: 1.一种用于适应不同设计的联接器的适配器联接器（1），其中适配器联接器（1）包括用于将适配器联接器（1）可释放地连接到第一联接器的第一连接机构，用于可释放地连接适配器联接器 1）连接到第二联轴器的牵引杆（50），以及用于将第一连接机构连接到第二连接机构的联接器壳体（2），并且其中第二连接机构包括张紧架（8） 所述第二联接器的所述牵引件（50）。 具有高度居中的机构的适配器联接器（1）包括连接到联接器壳体（2）的拉杆眼（14），其中拉杆眼（14）相对于张力轭（8）布置和构造，使得在 适配器联接器（1）插入到第二联轴器的牵引钩（50）的钳口中，牵引钩（50）可以与由张紧轭（8）形成的容纳以及与 拉杆眼（14）。

公开(公告)号：US08178109B2

公开(公告)日：2012-05-15

申请号：US12370559

申请日：2009-02-12

Applicant: Dirk Behrens ,  Elizabeth Bosch ,  Stephen K. Doberstein ,  Robert Forgan Halenbeck ,  Kevin Hestir ,  Min Mei Huang ,  Ernestine Lee ,  Haishan Lin ,  Thomas Linnemann ,  Shannon Marshall ,  Justin G. P. Wong ,  Ge Wu ,  Aileen Zhou ,  Cindy Leo ,  Lewis T. Williams

Inventor： Dirk Behrens ,  Elizabeth Bosch ,  Stephen K. Doberstein ,  Robert Forgan Halenbeck ,  Kevin Hestir ,  Min Mei Huang ,  Ernestine Lee ,  Haishan Lin ,  Thomas Linnemann ,  Shannon Marshall ,  Justin G. P. Wong ,  Ge Wu ,  Aileen Zhou ,  Cindy Leo ,  Lewis T. Williams

IPC: A61K39/00

CPC classification number: C07K16/243 ,  A61K38/00 ,  C07K14/53

Abstract: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.

Abstract translation: 公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。

公开(公告)号：US20110274480A1

公开(公告)日：2011-11-10

申请号：US13099537

申请日：2011-05-03

Applicant: Siegfried Kobert ,  Kay-Uwe Kolshorn ,  Dirk Behrens

Inventor： Siegfried Kobert ,  Kay-Uwe Kolshorn ,  Dirk Behrens

IPC: B60D1/00

CPC classification number: B61G5/04

Abstract: An adapter coupler (1) for adapting couplings of different design, wherein the adapter coupler (1) comprises a first connecting mechanism for releasably connecting the adapter coupler (1) to a first coupling, a second connecting mechanism for releasably connecting the adapter coupler (1) to the drawhook (50) of a second coupling, and a coupler housing (2) for connecting the first connecting mechanism to the second connecting mechanism, and wherein the second connecting mechanism comprises a tension yoke (8) with which to engage with the drawhook (50) of the second coupling. The adapter coupler (1) having a mechanism for height centering, comprising a drawbar eye (14) connected to the coupler housing (2), wherein the drawbar eye (14) is arranged and configured relative the tension yoke (8) such that upon the adapter coupler (1) being inserted into the jaw of the drawhook (50) of the second coupling, the drawhook (50) can engage in one joint process with both the accommodation formed by the tension yoke (8) as well as with the drawbar eye (14).

Abstract translation: 1.一种用于适应不同设计的联接器的适配器联接器（1），其中适配器联接器（1）包括用于将适配器联接器（1）可释放地连接到第一联接器的第一连接机构，用于可释放地连接适配器联接器 1）连接到第二联轴器的牵引杆（50），以及用于将第一连接机构连接到第二连接机构的联接器壳体（2），并且其中第二连接机构包括张紧架（8） 所述第二联接器的所述牵引件（50）。 具有高度居中的机构的适配器联接器（1）包括连接到联接器壳体（2）的拉杆眼（14），其中拉杆眼（14）相对于张力轭（8）布置和构造，使得在 适配器联接器（1）插入到第二联轴器的牵引钩（50）的钳口中，牵引钩（50）可以与由张紧轭（8）形成的容纳以及与 拉杆眼（14）。