-
公开(公告)号：US20100029930A1
公开(公告)日：2010-02-04
申请号：US11721563
申请日：2005-11-18
IPC分类号： C07H5/00
摘要： The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.
摘要翻译： 本发明涉及一种改善非氟化糖衍生物，特别是诸如1,3,4,6-四-O-乙酰基-2-O-三氟甲磺酰基-β-D-吡喃甘露糖的葡萄糖衍生物的稳定性的方法， 用作生产放射性氟化糖衍生物的前体，用于体内成像过程如正电子发射断层扫描（PET）。 该方法包括将非氟化糖衍生物储存在有机溶剂中。 还要求保护所得的非氟化糖衍生物制剂和包含其的自动化合成装置的盒。
-
公开(公告)号：US11185598B2
公开(公告)日：2021-11-30
申请号：US13582790
申请日：2011-03-22
IPC分类号： A61K49/04
摘要： The invention relates to a process for the preparation of a diagnostic X-ray composition. The composition comprises a non-ionic X-ray contrast agent in a pharmaceutically acceptable carrier. More particularly, the invention relates to a process for secondary production of X-ray compositions comprising X-ray contrast agents with a high dissolution temperature. When using the process of the invention, precipitation is avoided and degradation of the contrast agent is reduced. The process of the invention includes heat treatment of iodinated X-ray contrast agents at low pH.
-
公开(公告)号：US10000518B2
公开(公告)日：2018-06-19
申请号：US11721563
申请日：2005-11-18
摘要： The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-ß-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.
-
公开(公告)号：US20130004433A1
公开(公告)日：2013-01-03
申请号：US13582790
申请日：2011-03-22
IPC分类号： A61K49/04
CPC分类号： A61K49/0433 , A61K49/0452
摘要： The invention relates to a process for the preparation of a diagnostic X-ray composition. The composition comprises a non-ionic X-ray contrast agent in a pharmaceutically acceptable carrier. More particularly, the invention relates to a process for secondary production of X-ray compositions comprising X-ray contrast agents with a high dissolution temperature. When using the process of the invention, precipitation is avoided and degradation of the contrast agent is reduced. The process of the invention includes heat treatment of iodinated X-ray contrast agents at low pH.
摘要翻译： 本发明涉及一种用于制备诊断性X射线组合物的方法。 组合物包含药学上可接受的载体中的非离子X射线造影剂。 更具体地，本发明涉及一种二次生产包含具有高溶解温度的X射线造影剂的X射线组合物的方法。 当使用本发明的方法时，避免沉淀并降低造影剂的降解。 本发明的方法包括在低pH下热处理碘化X射线造影剂。
-
-
-
搜索结果
4 条记录 (耗时 0.015 秒)
