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公开(公告)号：US08053622B2
公开(公告)日：2011-11-08
申请号：US11909465
申请日：2006-03-21
申请人： Nigel John Osborn , Julian Grigg
发明人： Nigel John Osborn , Julian Grigg
IPC分类号： G21F9/14
CPC分类号： B01J20/08 , B01J20/3433 , B01J20/3475 , B01J2220/62 , C02F1/281 , C02F1/66 , C02F2101/006 , C02F2101/14 , C02F2201/006 , C02F2209/02 , C02F2303/16
摘要： The invention describes a method for stripping alumina which is particularly suitable for removal of fluoride from alumina and comprises washing said alumina with an aqueous acid or alkali at elevated temperature. The method may be used for removal of unreacted radiofluoride such as [18F]fluoride from alumina following a radiofluorination reaction. Automated synthesis apparatus and cassettes therefor, which are adapted to perform the method are also claimed.
摘要翻译： 本发明描述了一种剥离氧化铝的方法，其特别适用于从氧化铝中除去氟化物，并且包括用酸或碱水溶液在升高的温度下洗涤所述氧化铝。 该方法可用于在放射性氟化反应后从氧化铝中除去未反应的放射性氟化物，例如[18 F]氟化物。 还要求保护适用于执行该方法的自动合成装置及其盒。
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公开(公告)号：US20100029930A1
公开(公告)日：2010-02-04
申请号：US11721563
申请日：2005-11-18
IPC分类号： C07H5/00
摘要： The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.
摘要翻译： 本发明涉及一种改善非氟化糖衍生物，特别是诸如1,3,4,6-四-O-乙酰基-2-O-三氟甲磺酰基-β-D-吡喃甘露糖的葡萄糖衍生物的稳定性的方法， 用作生产放射性氟化糖衍生物的前体，用于体内成像过程如正电子发射断层扫描（PET）。 该方法包括将非氟化糖衍生物储存在有机溶剂中。 还要求保护所得的非氟化糖衍生物制剂和包含其的自动化合成装置的盒。
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公开(公告)号：US10000518B2
公开(公告)日：2018-06-19
申请号：US11721563
申请日：2005-11-18
摘要： The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-ß-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.
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公开(公告)号：US20090076259A1
公开(公告)日：2009-03-19
申请号：US11719601
申请日：2005-11-18
IPC分类号： C07H1/00
CPC分类号： A61K51/0491 , C07H1/00 , C07H13/04 , C07H13/10
摘要： The invention relates to an improved process for the fluoridation of sugar derivatives in which a controlled amount of water is present in the solvent.
摘要翻译： 本发明涉及在溶剂中存在受控量的水的糖衍生物的氟化的改进方法。
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公开(公告)号：US20080305042A1
公开(公告)日：2008-12-11
申请号：US12095923
申请日：2006-12-05
申请人： Michel Gacek , Hanno Priebe , Nigel John Osborn
发明人： Michel Gacek , Hanno Priebe , Nigel John Osborn
CPC分类号： C07B59/001 , A61K51/0402 , A61K51/1282
摘要： The present invention provides a method for the preparation of radioisotopically-labelled imaging agent compositions. The method uses precursors which are bound to soluble polymers, so that the radiolabelling reaction is carried out in solution. Also described are radiopharmaceutical compositions, automated versions of the radiolabelling method and disposable cassettes for use in the automated method.
摘要翻译： 本发明提供了一种制备放射性同位素标记显影剂组合物的方法。 该方法使用与可溶性聚合物结合的前体，使得放射性标记反应在溶液中进行。 还描述了放射性药物组合物，放射性标记方法的自动化版本和用于自动化方法的一次性盒。
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公开(公告)号：US20080226543A1
公开(公告)日：2008-09-18
申请号：US11909465
申请日：2006-03-21
申请人： Nigel John Osborn , Julian Grigg
发明人： Nigel John Osborn , Julian Grigg
CPC分类号： B01J20/08 , B01J20/3433 , B01J20/3475 , B01J2220/62 , C02F1/281 , C02F1/66 , C02F2101/006 , C02F2101/14 , C02F2201/006 , C02F2209/02 , C02F2303/16
摘要： The invention describes a method for stripping alumina which is particularly suitable for removal of fluoride from alumina and comprises washing said alumina with an aqueous acid or alkali at elevated temperature. The method may be used for removal of unreacted radiofluoride such as [18F]fluoride from alumina following a radiofluorination reaction. Automated synthesis apparatus and cassettes therefor, which are adapted to perform the method are also claimed.
摘要翻译： 本发明描述了一种剥离氧化铝的方法，其特别适用于从氧化铝中除去氟化物，并且包括用酸或碱水溶液在升高的温度下洗涤所述氧化铝。 该方法可用于在放射性氟化反应之后从氧化铝中除去未反应的放射性氟化物，例如[16 F]氟化物。 还要求保护适用于执行该方法的自动合成装置及其盒。
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