-
公开(公告)号：US4544545A
公开(公告)日：1985-10-01
申请号：US505696
申请日：1983-06-20
CPC分类号： A61K9/1271 , Y10S424/812
摘要： Phospholipid liposomes are provided having an outer layer including a cholesterol derivative such as a cholesterol ester and an aqueous medium confined by the layer which includes a tracer agent, a cytoxic agent or a therapeutic agent. The liposomes are adapted for specific organ targeting.
摘要翻译： 提供了具有包含胆固醇衍生物如胆固醇酯的外层和由包含示踪剂，细胞毒剂或治疗剂的层限定的水性介质的磷脂脂质体。 脂质体适用于特异性器官靶向。
-
公开(公告)号：US07060292B2
公开(公告)日：2006-06-13
申请号：US10165501
申请日：2002-06-07
IPC分类号： A61K9/127
CPC分类号： G01N33/92 , G01N33/582 , G01N33/586
摘要： This invention features in vitro methods of determining the rate and extent to which test compounds, such as drug candidates, enter, move within, and traverse lipid-associated barriers. This invention also features method that measure the accumulation, that is the partition coefficient, of test compounds in lipid structures relative to, e.g., an aqueous phase, as well as the rate of accumulation of test compounds in the lipid structures. In addition, the invention features lipid vesicles that contain fluorophores localized within the aqueous interior that can be employed in the methods described herein.
-
公开(公告)号：US4900540A
公开(公告)日：1990-02-13
申请号：US505697
申请日：1983-06-20
IPC分类号： A61K49/22
CPC分类号： A61K49/227 , Y10S436/829
摘要： Phospholipid liposomes are provided having a lipid bilayer surrounding a confined composition which includes a gas or a gas precursor. The liposomes can be administered to a patient and can be detected in vivo by ultrasound techniques which permit organ imaging.
摘要翻译： 提供了具有包围气体或气体前体的限制组合物的脂质双层的磷脂脂质体。 脂质体可以施用于患者，并且可以通过允许器官成像的超声技术在体内检测。
-
-
搜索结果
3 条记录 (耗时 0.013 秒)
