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公开(公告)号：US08784659B2
公开(公告)日：2014-07-22
申请号：US12892490
申请日：2010-09-28
申请人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Qing Zhao , Linna Wang , Dorothy Reynolds , Paul Frail , Juan Jiang , David M. Polizzotti
发明人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Qing Zhao , Linna Wang , Dorothy Reynolds , Paul Frail , Juan Jiang , David M. Polizzotti
IPC分类号： C02F1/50
CPC分类号： C02F1/50 , A01N47/44 , A01N47/48 , C02F2303/04 , C02F2303/20 , C02F2305/04 , C02F2305/14 , A01N25/04 , A01N2300/00
摘要： A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter, the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译： 已经发现了一种通过使用脂质体载体将抗微生物化合物引入复合生物膜基质的效率和有效性的方法，从而消除工业含水系统中的生物污垢，包括管道，热交换器，冷凝器，过滤系统和流体储存罐 。 根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦包含脂质体的抗微生物化合物变得与生物膜基质夹带，就可以进行脂质体的分解或程序分解。 此后，释放杀生物的水性核心直接与生物膜包裹的微生物反应。 当生物体死亡时，多糖/蛋白质基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，较少的胶体和颗粒固体的沉积以及溶解的有机物在微量过滤表面上 膜，从而降低膜清洗的频率和持续时间并最终更换。
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公开(公告)号：US20110177147A1
公开(公告)日：2011-07-21
申请号：US12868377
申请日：2010-08-25
申请人： Matthew M. Hunter , Jeffrey I. Melzer , Claudia C. Pierce , Linna Wang , Wilson K. Whitekettle , Guixi Zhang , Dorothy Reynolds
发明人： Matthew M. Hunter , Jeffrey I. Melzer , Claudia C. Pierce , Linna Wang , Wilson K. Whitekettle , Guixi Zhang , Dorothy Reynolds
CPC分类号： C02F1/50 , A01N25/28 , A01N43/80 , C02F5/00 , C02F2303/08 , C02F2303/20 , C02F2305/14 , A01N25/22 , A01N2300/00
摘要： An improved stabilized biocidal delivery system has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex bio-film matrices through the use of liposome vesicular carriers, thereby removing the bio-fouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. The improved stabilized biocide is comprised of a vesicle encapsulated biocide that is stabilized against chemical and heat degradation over longer periods of time than previously possible through the incorporation of a stabilizer compound.
摘要翻译： 已经发现改进的稳定杀生物递送系统通过使用脂质体水泡载体来增加将抗微生物化合物引入复杂生物膜基质的效率和有效性，从而消除工业含水系统中的生物污染，包括管道，热交换 ，冷凝器，过滤系统和液体储罐。 改进的稳定的杀生物剂由囊泡包封的杀生物剂组成，其通过掺入稳定剂化合物而比以前可能通过更长的时间段稳定化学和热降解。
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公开(公告)号：US20110052656A1
公开(公告)日：2011-03-03
申请号：US12892490
申请日：2010-09-28
申请人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Qing Zhao , Linna Wang , Dorothy Reynolds , Paul Frail , Juan Jiang , David M. Polizzotti
发明人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Qing Zhao , Linna Wang , Dorothy Reynolds , Paul Frail , Juan Jiang , David M. Polizzotti
IPC分类号： A01N25/26 , A61K31/04 , A01N43/78 , A01N33/02 , A01N47/00 , A01N37/52 , A01N43/66 , A01N57/34 , A01N35/00 , A01N37/44 , A01N43/88 , A01N43/80 , A01N59/20 , A01N59/16 , A01N59/08 , A01N59/24 , A01N39/00 , A01N59/26 , A01P1/00
CPC分类号： C02F1/50 , A01N47/44 , A01N47/48 , C02F2303/04 , C02F2303/20 , C02F2305/04 , C02F2305/14 , A01N25/04 , A01N2300/00
摘要： A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter, the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译： 已经发现了一种通过使用脂质体载体将抗微生物化合物引入复合生物膜基质的效率和有效性的方法，从而消除工业含水系统中的生物污垢，包括管道，热交换器，冷凝器，过滤系统和流体储存罐 。 根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦包含脂质体的抗微生物化合物变得与生物膜基质夹带，就可以进行脂质体的分解或程序分解。 此后，释放杀生物的水性核心直接与生物膜包裹的微生物反应。 当生物体死亡时，多糖/蛋白质基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，较少的胶体和颗粒固体的沉积以及溶解的有机物在微量过滤表面上 膜，从而降低膜清洗的频率和持续时间并最终更换。
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