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    Method for controlling microbial biofilm in aqueous systems
    3.
    发明授权
    Method for controlling microbial biofilm in aqueous systems 有权
    在水系统中控制微生物生物膜的方法

    公开(公告)号：US08784659B2

    公开(公告)日：2014-07-22

    申请号：US12892490

    申请日：2010-09-28

    申请人： Wilson Kurt Whitekettle ,  Gloria Jean Tafel ,  Qing Zhao ,  Linna Wang ,  Dorothy Reynolds ,  Paul Frail ,  Juan Jiang ,  David M. Polizzotti

    发明人： Wilson Kurt Whitekettle ,  Gloria Jean Tafel ,  Qing Zhao ,  Linna Wang ,  Dorothy Reynolds ,  Paul Frail ,  Juan Jiang ,  David M. Polizzotti

    IPC分类号： C02F1/50

    CPC分类号： C02F1/50 ,  A01N47/44 ,  A01N47/48 ,  C02F2303/04 ,  C02F2303/20 ,  C02F2305/04 ,  C02F2305/14 ,  A01N25/04 ,  A01N2300/00

    摘要： A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter, the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.

    摘要翻译： 已经发现了一种通过使用脂质体载体将抗微生物化合物引入复合生物膜基质的效率和有效性的方法，从而消除工业含水系统中的生物污垢，包括管道，热交换器，冷凝器，过滤系统和流体储存罐 。 根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦包含脂质体的抗微生物化合物变得与生物膜基质夹带，就可以进行脂质体的分解或程序分解。 此后，释放杀生物的水性核心直接与生物膜包裹的微生物反应。 当生物体死亡时，多糖/蛋白质基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，较少的胶体和颗粒固体的沉积以及溶解的有机物在微量过滤表面上 膜，从而降低膜清洗的频率和持续时间并最终更换。

    METHOD FOR CONTROLLING MICROBIAL BIOFILM IN AQUEOUS SYSTEMS
    5.
    发明申请
    METHOD FOR CONTROLLING MICROBIAL BIOFILM IN AQUEOUS SYSTEMS 有权
    用于控制水质体系中微生物生物学的方法

    公开(公告)号：US20110052656A1

    公开(公告)日：2011-03-03

    申请号：US12892490

    申请日：2010-09-28

    申请人： Wilson Kurt Whitekettle ,  Gloria Jean Tafel ,  Qing Zhao ,  Linna Wang ,  Dorothy Reynolds ,  Paul Frail ,  Juan Jiang ,  David M. Polizzotti

    发明人： Wilson Kurt Whitekettle ,  Gloria Jean Tafel ,  Qing Zhao ,  Linna Wang ,  Dorothy Reynolds ,  Paul Frail ,  Juan Jiang ,  David M. Polizzotti

    IPC分类号： A01N25/26 ,  A61K31/04 ,  A01N43/78 ,  A01N33/02 ,  A01N47/00 ,  A01N37/52 ,  A01N43/66 ,  A01N57/34 ,  A01N35/00 ,  A01N37/44 ,  A01N43/88 ,  A01N43/80 ,  A01N59/20 ,  A01N59/16 ,  A01N59/08 ,  A01N59/24 ,  A01N39/00 ,  A01N59/26 ,  A01P1/00

    CPC分类号： C02F1/50 ,  A01N47/44 ,  A01N47/48 ,  C02F2303/04 ,  C02F2303/20 ,  C02F2305/04 ,  C02F2305/14 ,  A01N25/04 ,  A01N2300/00

    摘要： A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter, the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.

    摘要翻译： 已经发现了一种通过使用脂质体载体将抗微生物化合物引入复合生物膜基质的效率和有效性的方法，从而消除工业含水系统中的生物污垢，包括管道，热交换器，冷凝器，过滤系统和流体储存罐 。 根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。 与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。 一旦包含脂质体的抗微生物化合物变得与生物膜基质夹带，就可以进行脂质体的分解或程序分解。 此后，释放杀生物的水性核心直接与生物膜包裹的微生物反应。 当生物体死亡时，多糖/蛋白质基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，较少的胶体和颗粒固体的沉积以及溶解的有机物在微量过滤表面上 膜，从而降低膜清洗的频率和持续时间并最终更换。

    METHOD FOR REMOVING MICROBES FROM SURFACES
    6.
    发明申请
    METHOD FOR REMOVING MICROBES FROM SURFACES 审中-公开
    从表面除去微生物的方法

    公开(公告)号：US20080274929A1

    公开(公告)日：2008-11-06

    申请号：US11742817

    申请日：2007-05-01

    申请人： Wilson K. Whitekettle ,  Juan Jiang ,  Linna Wang

    发明人： Wilson K. Whitekettle ,  Juan Jiang ,  Linna Wang

    IPC分类号： C11D3/43

    CPC分类号： C02F1/50 ,  A01N33/04 ,  C02F2103/023 ,  C02F2103/10 ,  C02F2103/16 ,  C02F2103/28 ,  C02F2303/04 ,  C02F2305/04 ,  C11D3/3723 ,  C11D3/48

    摘要： A method has been found for the removal of microbial biofilm on surfaces in contact with systems, including but not limited to aqueous systems, which comprises adding to the aqueous system an effective amount of a polyethyleneimine surfactant to substantially remove microbial biofilm, from surfaces in aquatic systems, while presenting minimal danger to non-target aquatic organisms at discharge due to their very low discharge concentrations.

    摘要翻译： 已经发现一种用于在与系统接触的表面上去除微生物生物膜的方法，包括但不限于水性体系，其包括向水性体系中加入有效量的聚乙烯亚胺表面活性剂以从水生物质表面基本上除去微生物生物膜 系统，同时由于其非常低的排放浓度而对非目标水生生物排放施加极小的危险。

    WATER SOLUBLE PACKAGE FILMS FOR ACIDIC HIGH WATER CONTENT PRODUCT AND METHOD OF PRODUCING THE SAME
    8.
    发明申请
    WATER SOLUBLE PACKAGE FILMS FOR ACIDIC HIGH WATER CONTENT PRODUCT AND METHOD OF PRODUCING THE SAME 审中-公开
    用于酸性高含水量产品的水溶性包装膜及其生产方法

    公开(公告)号：US20130256237A1

    公开(公告)日：2013-10-03

    申请号：US13128476

    申请日：2010-12-20

    申请人： Linna Wang ,  Guixi Zhang

    发明人： Linna Wang ,  Guixi Zhang

    IPC分类号： B65D85/84 ,  C02F1/68

    CPC分类号： B65D11/00 ,  B32B27/08 ,  B32B27/306 ,  B32B27/308 ,  B32B2307/7166 ,  B32B2439/40 ,  B65D65/46 ,  C02F1/50 ,  C02F1/68 ,  C02F2103/023 ,  C02F2305/14

    摘要： A packaging system for an acidic product and a method for adding the acid product to a water system, wherein the packaging system has a multi-layer packaging film with a water-soluble outer layer and an inner layer comprising a pH-sensitive polymer. The inner layer is stable at the pH of the acidic product and dissolves when exposed to a pH greater than dissolution pH of the inner layer, the dissolution pH being greater than the pH of the acidic product. In one example, the dissolution pH of the inner layer is between 5 to 8. When the pH of the water system reaches the dissolution pH, the product is released to the water system.

    摘要翻译： 用于酸性产品的包装系统和将酸产品加入到水系统中的方法，其中所述包装系统具有具有水溶性外层的多层包装膜和包含pH敏感聚合物的内层。 内层在酸性产物的pH下是稳定的，当暴露于大于内层的溶解pH的pH时溶解，溶解pH大于酸性产物的pH。 在一个实例中，内层的溶解pH在5至8之间。当水体系的pH达到溶解pH时，产物释放到水体系中。