公开(公告)号：US06737237B1

公开(公告)日：2004-05-18

申请号：US09631594

申请日：2000-08-03

申请人： Rima L. McLeod ,  Craig W. Roberts ,  Fiona Roberts ,  Jennifer J. Johnson ,  Michael Kirisits ,  David Ferguson ,  Russell Lyons ,  Ernest Mui ,  Doug Mack ,  Benjamin Samuel ,  Piotr Gornicki ,  Ellen Zuther

发明人： Rima L. McLeod ,  Craig W. Roberts ,  Fiona Roberts ,  Jennifer J. Johnson ,  Michael Kirisits ,  David Ferguson ,  Russell Lyons ,  Ernest Mui ,  Doug Mack ,  Benjamin Samuel ,  Piotr Gornicki ,  Ellen Zuther

IPC分类号： C12Q168

CPC分类号： C12Q1/18 ,  A61K39/002

摘要： This invention relates uses of Toxoplasma gondii chorismate synthase, a component components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, in assays to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on T. gondii chorismate synthase and its inhibitors.

摘要翻译： 本发明涉及弓形体弓形体合成酶的应用，其不包括psbA或PPi磷酸果糖激酶的植物样代谢途径的组成成分，并且通常不能在动物中操作或由质体DNA编码，以用于开发干扰Apicomplexan生长和存活的组合物 。 途径的组成部分包括酶，转运肽和编码酶和肽的核苷酸序列，或这些核苷酸序列的启动子，其中抗体，反义分子和其它抑制剂被引导。 诊断和治疗试剂和疫苗是基于弓形虫绒毛膜合成酶及其抑制剂开发的。

公开(公告)号：US20050142113A1

公开(公告)日：2005-06-30

申请号：US10824194

申请日：2004-04-14

申请人： Rima McLeod ,  Craig Roberts ,  Fiona Roberts ,  Jennifer Johnson ,  Michael Kirisits ,  David Ferguson ,  Russell Lyons ,  Ernest Mui ,  Doug Mack ,  Benjamin Samuel ,  Piotr Gornicki ,  Ellen Zuther

发明人： Rima McLeod ,  Craig Roberts ,  Fiona Roberts ,  Jennifer Johnson ,  Michael Kirisits ,  David Ferguson ,  Russell Lyons ,  Ernest Mui ,  Doug Mack ,  Benjamin Samuel ,  Piotr Gornicki ,  Ellen Zuther

IPC分类号： A61K39/002 ,  C12Q1/18 ,  A61K48/00 ,  A01H5/00 ,  A01N63/00

CPC分类号： C12Q1/18 ,  A61K39/002

摘要： This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.

摘要翻译： 本发明涉及不包括psbA或PPi磷酸果糖激酶的植物样代谢途径的组分的用途，并且通常不在动物中操作或由质体DNA编码，以开发干扰Apicomplexan生长和存活的组合物。 途径的组成部分包括酶，转运肽和编码酶和肽的核苷酸序列，或这些核苷酸序列的启动子，其中抗体，反义分子和其它抑制剂被引导。 基于组分及其抑制剂开发诊断和治疗试剂和疫苗。