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公开(公告)号:US4810650A
公开(公告)日:1989-03-07
申请号:US99594
申请日:1987-09-22
申请人: Douglas B. Kell , Robert W. Todd
发明人: Douglas B. Kell , Robert W. Todd
IPC分类号: G01N27/22 , G01N33/487 , C12M , G01R11/52
CPC分类号: G01N33/48735
摘要: Apparatus for the determination of biomass in a suspension and its use in a fermentation apparatus. The apparatus includes electrodes to be placed in the suspension and the following other components: circuit for applying an alternating voltage between the electrodes; circuit for providing a current signal indicative of the current in the current electrode circuit; circuit for providing a voltage signal indicative of the voltage between the ratio between the value of the voltage signal and the value of a quadrature component of the current signal, or vice versa, to provide a capacitance dependent signal.
摘要翻译: 用于测定悬浮液中生物量的装置及其在发酵装置中的用途。 该装置包括放置在悬架中的电极和以下其他部件:用于在电极之间施加交流电压的电路; 电路,用于提供指示当前电极电路中的电流的电流信号; 电路,用于提供指示电压信号的值与当前信号的正交分量的值之间的电压的电压信号,反之亦然,以提供电容相关信号。
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公开(公告)号:US5569591A
公开(公告)日:1996-10-29
申请号:US278725
申请日:1994-07-21
IPC分类号: G01N33/487 , C12Q1/02
CPC分类号: G01N33/48735
摘要: Cellular biological material (such as living tissue) is analysed or monitored by applying an AC electrical potential across the biological material so as to produce a nonlinear dielectric spectrum, and obtaining a detectable signal corresponding to the resulting spectrum. The potential is of a first frequency and the measured response at one or more second frequency substantially not overlapping with the first frequency.
摘要翻译: 通过在生物材料上施加AC电位来分析或监测细胞生物材料(例如活组织),以产生非线性介电谱,并获得对应于所得光谱的可检测信号。 该电位具有第一频率,并且在一个或多个第二频率处的测量响应基本上不与第一频率重叠。
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公开(公告)号:US4965206A
公开(公告)日:1990-10-23
申请号:US479211
申请日:1990-02-09
申请人: Douglas B. Kell
发明人: Douglas B. Kell
IPC分类号: G01N27/22 , G01N33/487
CPC分类号: G01N33/48735
摘要: Method and apparatus for the determination of biomass in a suspension, such as a culture, in `real` time and a fermentation process using the method. In the method the electrical capacitance of the suspension is measured and from the measurement the volume fraction of the suspension enclosed by the cytoplasmic membranes of the cells (biovolume) is determined.
摘要翻译: 用于在“实际”时间和使用该方法的发酵过程中测定悬浮液(例如培养物)中生物量的方法和装置。 在该方法中,测量悬浮液的电容,并且从测量中确定由细胞的细胞质膜(生物体积)包围的悬浮液的体积分数。
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公开(公告)号:US08383126B2
公开(公告)日:2013-02-26
申请号:US11978257
申请日:2007-10-29
申请人: Galina V. Mukamolova , Arseny S. Kaprelyants , Danielle I. Young , Douglas B. Kell , Michael Young
发明人: Galina V. Mukamolova , Arseny S. Kaprelyants , Danielle I. Young , Douglas B. Kell , Michael Young
CPC分类号: C07K14/33 , A61K38/00 , A61K39/00 , C07K14/195 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/335 , C07K14/34 , C07K14/35 , C07K14/36
摘要: RP-factors, their cognate receptors, convertases, respective genes and inhibitors or mimetics thereof are described. In particular, antibodies, pharmaceutical compositions and (therapeutic, diagnostic) methods based on the RP-factors and their receptors/convertases are described.
摘要翻译: 描述了RP因子,它们的同源受体,转化酶,各自的基因和抑制剂或其模拟物。 特别地,描述了基于RP因子及其受体/转化酶的抗体,药物组合物和(治疗,诊断)方法。
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公开(公告)号:US20080206269A1
公开(公告)日:2008-08-28
申请号:US11978257
申请日:2007-10-29
申请人: Galina V. Mukamolova , Arseny S. Kaprelyants , Michael Young , Douglas B. Kell , Danielle I. Young
发明人: Galina V. Mukamolova , Arseny S. Kaprelyants , Michael Young , Douglas B. Kell , Danielle I. Young
CPC分类号: C07K14/33 , A61K38/00 , A61K39/00 , C07K14/195 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/335 , C07K14/34 , C07K14/35 , C07K14/36
摘要: RP-factors, their cognate receptors, convertases, respective genes and inhibitors or mimetics thereof are described. In particular, antibodies, pharmaceutical compositions and (therapeutic, diagnostic) methods based on the RP-factors and their receptors/convertases are described
摘要翻译: 描述了RP因子,它们的同源受体,转化酶,各自的基因和抑制剂或其模拟物。 特别地,描述了基于RP因子及其受体/转化酶的抗体,药物组合物和(治疗,诊断)方法
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公开(公告)号:US08431354B1
公开(公告)日:2013-04-30
申请号:US09445289
申请日:1998-06-03
IPC分类号: G01N33/554 , G01N33/53 , C12Q1/70 , C12N5/00
CPC分类号: C07K14/33 , A61K38/00 , A61K39/00 , C07K14/195 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/335 , C07K14/34 , C07K14/35 , C07K14/36
摘要: RP-factors, their cognate receptors, convertases, respective genes and inhibitors or mimetics thereof are described. In particular, antibodies, pharmaceutical compositions and (therapeutic, diagnostic) methods based on the RP-factors and their receptors/convertases are described.
摘要翻译: 描述了RP因子,它们的同源受体,转化酶,各自的基因和抑制剂或其模拟物。 特别地,描述了基于RP因子及其受体/转化酶的抗体,药物组合物和(治疗,诊断)方法。
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