公开(公告)号：US08823923B2

公开(公告)日：2014-09-02

申请号：US13426220

申请日：2012-03-21

申请人： Elena S. F. Berman ,  John R. Speakman ,  Manish Gupta ,  Edward L. Melanson, Jr. ,  Susan L. Fortson ,  Douglas S. Baer

发明人： Elena S. F. Berman ,  John R. Speakman ,  Manish Gupta ,  Edward L. Melanson, Jr. ,  Susan L. Fortson ,  Douglas S. Baer

IPC分类号： G01N33/48 ,  G01N21/03 ,  G01N21/35 ,  G01N21/39

CPC分类号： G01N21/031 ,  G01N21/3577 ,  G01N21/39

摘要： A method of measuring energy expenditure in a living subject comprises: (a) administering a specified dose of doubly-labeled water (2H218O) to a living subject; (b) obtaining samples at three or more times of body water from the living subject; (c) measuring 2H/1H, 17O/16O and 18O/16O ratios in each of the obtained samples using optical spectroscopy; and (d) determining (1) a combined value of flux of body water and exhaled carbon dioxide from a change in measured 18O/16O over time, (2) a value of flux of body water alone from a change in measured 2H/1H over time, and (3) a reference value of isotopic background fluctuation from a change in measured 17O/16O over time. Using 17O measurements to estimate background fluctuations of the 2H and 18O decreases the required isotope dosing of subjects or decreases uncertainty at current dosing levels.

摘要翻译： 一种测量活体受试者能量消耗的方法包括：（a）向生物体施用指定剂量的双重标记水（2H218O）; （b）从活体取得3次或3次以上的体力水样品; （c）使用光谱测量每个获得的样品中的2H / 1H，17O / 16O和18O / 16O比值; （d）根据测量的18O / 16O随时间的变化，确定（1）体内水分和呼出二氧化碳的通量的组合值，（2）单独的身体水流量与测量的2H / 1H的变化值 随着时间的推移，（3）随着时间的推移，测量的17O / 16O的变化同位素背景波动的参考值。 使用17O测量来估计2H和18O的背景波动可减少受试者所需的同位素剂量，或降低当前剂量水平下的不确定性。

公开(公告)号：US20130027705A1

公开(公告)日：2013-01-31

申请号：US13426220

申请日：2012-03-21

申请人： Elena S.F. Berman ,  John R. Speakman ,  Manish Gupta ,  Edward L. Melanson, JR. ,  Susan L. Fortson ,  Douglas S. Baer

发明人： Elena S.F. Berman ,  John R. Speakman ,  Manish Gupta ,  Edward L. Melanson, JR. ,  Susan L. Fortson ,  Douglas S. Baer

IPC分类号： G01J3/42

CPC分类号： G01N21/031 ,  G01N21/3577 ,  G01N21/39

摘要： A method of measuring energy expenditure in a living subject comprises: (a) administering a specified dose of doubly-labeled water (2H218O) to a living subject; (b) obtaining samples at three or more times of body water from the living subject; (c) measuring 2H/1H, 17O/16O and 18O/16O ratios in each of the obtained samples using optical spectroscopy; and (d) determining (1) a combined value of flux of body water and exhaled carbon dioxide from a change in measured 18O/16O over time, (2) a value of flux of body water alone from a change in measured 2H/1H over time, and (3) a reference value of isotopic background fluctuation from a change in measured 17O/16O over time. Using 17O measurements to estimate background fluctuations of the 2H and 18O decreases the required isotope dosing of subjects or decreases uncertainty at current dosing levels.

摘要翻译： 一种测量活体受试者能量消耗的方法包括：（a）向生物体施用指定剂量的双重标记水（2H218O）; （b）从活体取得3次或3次以上的体力水样品; （c）使用光谱测量每个获得的样品中的2H / 1H，17O / 16O和18O / 16O比值; （d）根据测量的18O / 16O随时间的变化，确定（1）体内水分和呼出二氧化碳的通量的组合值，（2）单独的身体水流量与测量的2H / 1H的变化值 随着时间的推移，（3）随着时间的推移，测量的17O / 16O的变化同位素背景波动的参考值。 使用17O测量来估计2H和18O的背景波动可减少受试者所需的同位素剂量，或降低当前剂量水平下的不确定性。

公开(公告)号：US07468797B1

公开(公告)日：2008-12-23

申请号：US11466348

申请日：2006-08-22

申请人： Anthony O'Keefe ,  Manish Gupta ,  Thomas G. Owano ,  Douglas S. Baer

发明人： Anthony O'Keefe ,  Manish Gupta ,  Thomas G. Owano ,  Douglas S. Baer

IPC分类号： G01N21/00

CPC分类号： G01N21/31 ,  G01J3/42 ,  G01N21/031

摘要： An absorption spectroscopy instrument is provided with a re-injection mirror to greatly increase the optical power coupled into an optical cavity, comprised of two or more mirrors, for the purpose of increasing the quality of absorption and extinction measurements made in the cavity. Light reflected from the first cavity mirror upon which a light beam is incident, can be efficiently collected and back reflected onto the same mirror, effectively producing a plurality of optical injections into the cavity. The instrument can be used for off-axis cavity ringdown spectroscopy, off-axis integrated cavity output spectroscopy, or other cavity-based spectroscopy applications.

摘要翻译： 吸收光谱仪器具有再注射镜，以大大增加耦合到由两个或更多个镜子组成的光学腔中的光功率，以增加在空腔中进行的吸收和消光测量的质量。 从入射光束的第一腔镜反射的光可以被有效地收集并反射回到相同的反射镜上，有效地产生多个光学注入到空腔中。 该仪器可用于离轴腔衰减光谱，离轴积分腔体输出光谱或其他基于腔的光谱应用。

公开(公告)号：US07298490B2

公开(公告)日：2007-11-20

申请号：US11240190

申请日：2005-09-30

申请人： Douglas S. Baer ,  Manish Gupta ,  Thomas Owano ,  Anthony O'Keefe

发明人： Douglas S. Baer ,  Manish Gupta ,  Thomas Owano ,  Anthony O'Keefe

IPC分类号： G01B9/02 ,  G01J3/45

CPC分类号： G01N21/3504 ,  G01N21/39

摘要： The disclosure describes an absorption spectroscopy method for sensing hydrogen gas in a sample atmosphere and an associated hydrogen sensor. A light beam, having a wavelength corresponding to a vibrational transition of hydrogen molecules from a ground vibration state to any excited rotational vibration state via a quadrupole interaction, is introduced into an optical cavity adapted to receive a sample atmosphere to be tested for the presence of hydrogen gas. The light is introduced into the cavity in an off-axis alignment to systematically eliminate cavity resonances, while preserving the absorption signal amplifying properties of such cavities. Hydrogen absorption is measured is terms of cavity output, as in the ICOS technique.

摘要翻译： 本公开描述了用于检测样品气氛中的氢气和相关联的氢传感器的吸收光谱法。 具有对应于氢分子从地面振动状态到任何激发的旋转振动状态的经四极相互作用的振动转变的波长的光束被引入适于接收待测样品气氛的光学腔， 氢气。 光以离轴对准引入空腔，以系统地消除空腔谐振，同时保持这种空腔的吸收信号放大性能。 氢吸收测量是空腔输出的术语，如ICOS技术。