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1.发明公开公开(公告)号：US20240316182A1
公开(公告)日：2024-09-26
申请号：US18351512
申请日：2022-01-14
Inventor： Ki Hwan Kwon , Ji Hwa Chung
CPC classification number: A61K39/215 , A61K9/19 , A61K9/5063 , A61P31/14 , C12N7/00 , A61K2039/55555 , A61K2039/572 , C12N2770/20033
Abstract: The present invention relates to an extracellular vesicle including a coronavirus-derived antigen protein or a gene encoding the protein, and a use of the extracellular vesicle. According to the present invention, when mice are immunized by administering an activated immune cell-derived extracellular vesicle loaded with an antigen protein or mRNA, excellent antigen-specific neutralizing antibody production and T cell response induction effects are confirmed. When the extracellular vesicle is stored under room-temperature and refrigerated conditions after freeze-drying, high stability and an excellent antibody production effect are experimentally confirmed. From these results, the extracellular vesicle according to the present invention or a vaccine composition including the same may serve as a platform applicable to various diseases with an excellent antigen-specific immune response induction effect and excellent stability, and thus is expected to be effectively used for the development of vaccines for preventing or treating various diseases including infectious diseases, particularly coronavirus infections.
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公开(公告)号：US20250082349A1
公开(公告)日：2025-03-13
申请号：US18288030
申请日：2023-10-13
Applicant: EXOLLENCE CO., LTD.
Inventor： Jihwa CHUNG , Minyoung LEE
IPC: A61B17/22 , A61B17/00 , A61B17/221 , A61B17/225 , A61B18/24 , A61B18/26
Abstract: The present invention relates to an extracorporeal shock wave device for loading a target substance into a delivery vehicle. According to the present invention, the time taken to load the target substance into the delivery vehicle can be significantly reduced, and the loading rate can also be greatly improved.
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