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公开(公告)号：US08318916B2
公开(公告)日：2012-11-27
申请号：US13198263
申请日：2011-08-04
IPC分类号： C07H21/04
CPC分类号： C07K16/2818 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/025 , A01K2267/03 , A01K2267/0325 , A01K2267/0381 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C12N15/8509 , Y02A50/386 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： The present invention provides novel human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
摘要翻译： 本发明提供了针对人CTLA-4的新型人序列抗体以及使用这些抗体治疗人类疾病，感染和其他病症的方法。
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公开(公告)号：US20110296546A1
公开(公告)日：2011-12-01
申请号：US13198263
申请日：2011-08-04
CPC分类号： C07K16/2818 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/025 , A01K2267/03 , A01K2267/0325 , A01K2267/0381 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C12N15/8509 , Y02A50/386 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： The present invention provides novel human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
摘要翻译： 本发明提供了针对人CTLA-4的新型人序列抗体以及使用这些抗体治疗人类疾病，感染和其他病症的方法。
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公开(公告)号：US20100047244A1
公开(公告)日：2010-02-25
申请号：US12564756
申请日：2009-09-22
IPC分类号： A61K39/395 , A61P35/04
CPC分类号： C07K16/2818 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/025 , A01K2267/03 , A01K2267/0325 , A01K2267/0381 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C12N15/8509 , Y02A50/386 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： The present invention provides novel human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
摘要翻译： 本发明提供了针对人CTLA-4的新型人序列抗体以及使用这些抗体治疗人类疾病，感染和其他病症的方法。
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公开(公告)号：US08784815B2
公开(公告)日：2014-07-22
申请号：US13666672
申请日：2012-11-01
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2818 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/025 , A01K2267/03 , A01K2267/0325 , A01K2267/0381 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C12N15/8509 , Y02A50/386 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： The present invention provides novel human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
摘要翻译： 本发明提供了针对人CTLA-4的新型人序列抗体以及使用这些抗体治疗人类疾病，感染和其他病症的方法。
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公开(公告)号：US08563694B2
公开(公告)日：2013-10-22
申请号：US13388028
申请日：2010-07-26
申请人： Jennifer Marie Mataraza , Andrea Van Elsas , Alan J. Korman , Edward L. Halk , Kent B. Thudium , Mark Selby , Timothy W. Sproul , Heidi N. Leblanc
发明人： Jennifer Marie Mataraza , Andrea Van Elsas , Alan J. Korman , Edward L. Halk , Kent B. Thudium , Mark Selby , Timothy W. Sproul , Heidi N. Leblanc
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/2818 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to binding compounds specific for BTLA and uses thereof. More specifically, the invention relates to fully human antibodies that recognize human BTLA and modulate its activity in cancer, inflammatory, and autoimmune disorders.
摘要翻译： 本发明涉及对BTLA特异性的结合化合物及其用途。 更具体地，本发明涉及识别人BTLA并调节其在癌症，炎性和自身免疫性疾病中的活性的完全人抗体。
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公开(公告)号：US08137667B2
公开(公告)日：2012-03-20
申请号：US12653137
申请日：2009-12-09
IPC分类号： A61K39/395
CPC分类号： C07K16/2878 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K2039/505 , A61K2039/53 , A61K2039/55516 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/75 , C07K2317/92 , C12N2740/15034 , A61K2300/00
摘要： Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeutically effective amount of the antibody to said subject.
摘要翻译： 与人4-1BB结合并允许人4-1BB与人4-1BB配体结合的完全人抗体及其抗原结合部分。 一方面，抗体是IgG4抗体。 还提供了治疗受试者疾病的方法，包括向所述受试者施用治疗有效量的抗体。
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7.发明申请ANTI-CTLA-4 ANTIBODIES WITH REDUCED BLOCKING OF BINDING OF CTLA-4 TO B7 AND USES THEREOF 有权抗CTLA-4抗CTLA-4与B7结合阻断的抗体及其用途公开(公告)号：US20110081354A1
公开(公告)日：2011-04-07
申请号：US12866149
申请日：2009-02-04
申请人： Alan Korman , Edward L. Halk , Changyu Wang , Kent B. Thudium , Lan Yang , Kristopher Toy
发明人： Alan Korman , Edward L. Halk , Changyu Wang , Kent B. Thudium , Lan Yang , Kristopher Toy
IPC分类号： A61K39/395 , C07K16/28 , A61P35/00
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/55516 , C07K2317/52 , C07K2317/565 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： The present invention provides isolated monoclonal antibodies that bind to CTLA-4 and that are capable of increasing the response of T cells to antigenic stimulation in vivo yet the antibodies do not substantially block the binding of CTLA-4 to B7 ligands (e.g., B7-1 and B7-2) in vitro. Thus, the antibodies of the invention demonstrate that is it possible to separate the immunostimulatory function of anti-CTLA-4 antibodies from their ability to block the binding of B7 ligands. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for increasing the response of T cells to antigenic stimulation using the antibodies of the invention, including methods for treating cancer using the antibodies of the invention.
摘要翻译： 本发明提供了与CTLA-4结合并且能够增加T细胞对体内抗原刺激的反应的分离的单克隆抗体，但是该抗体基本上不阻断CTLA-4与B7配体的结合（例如，B7- 1和B7-2）。 因此，本发明的抗体证明可以将抗CTLA-4抗体的免疫刺激功能从其阻断B7配体结合的能力分离出来。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体增加T细胞对抗原刺激的应答的方法，包括使用本发明的抗体治疗癌症的方法。
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公开(公告)号：US20110003319A1
公开(公告)日：2011-01-06
申请号：US12878679
申请日：2010-09-09
申请人： KAZUMA TOMIZUKA , ISAO ISHIDA , NILS LONBERG , EDWARD L. HALK
发明人： KAZUMA TOMIZUKA , ISAO ISHIDA , NILS LONBERG , EDWARD L. HALK
IPC分类号： C12N5/20 , G01N33/566
CPC分类号： A01K67/0278 , A01K67/02 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K39/00 , A61K2039/505 , C07K14/70535 , C07K16/00 , C07K16/18 , C07K16/243 , C07K16/2812 , C07K16/2818 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/92 , C12N5/0635 , C12N5/163 , C12N15/8509 , C12N2015/8518 , C12P21/005 , C12Q1/6881 , C12Q2600/158
摘要： The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
摘要翻译： 本发明提供能够产生人序列抗体的新型转基因非人哺乳动物，以及生产和使用这些抗体的方法。
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公开(公告)号：US20100183621A1
公开(公告)日：2010-07-22
申请号：US12653137
申请日：2009-12-09
IPC分类号： A61K39/395 , C07K16/28 , A61P35/00 , C07H21/04
CPC分类号： C07K16/2878 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K2039/505 , A61K2039/53 , A61K2039/55516 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/75 , C07K2317/92 , C12N2740/15034 , A61K2300/00
摘要： Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeutically effective amount of the antibody to said subject.
摘要翻译： 与人4-1BB结合并允许人4-1BB与人4-1BB配体结合的完全人抗体及其抗原结合部分。 一方面，抗体是IgG4抗体。 还提供了治疗受试者疾病的方法，包括向所述受试者施用治疗有效量的抗体。
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公开(公告)号：US07288638B2
公开(公告)日：2007-10-30
申请号：US10961567
申请日：2004-10-08
IPC分类号： C07K16/28 , C07K16/00 , A61K39/395
CPC分类号： C07K16/2878 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K2039/505 , A61K2039/53 , A61K2039/55516 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/75 , C07K2317/92 , C12N2740/15034 , A61K2300/00
摘要： Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeutically effective amount of the antibody to said subject.
摘要翻译： 与人4-1BB结合并允许人4-1BB与人4-1BB配体结合的完全人抗体及其抗原结合部分。 一方面，抗体是IgG4抗体。 还提供了治疗受试者疾病的方法，包括向所述受试者施用治疗有效量的抗体。
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