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公开(公告)号：US20120321674A1
公开(公告)日：2012-12-20
申请号：US13400065
申请日：2012-02-18
申请人： Michael Vachon , Edward M. RUDNIC
发明人： Michael Vachon , Edward M. RUDNIC
IPC分类号： A61K9/00 , A61K31/485
CPC分类号： A61K31/485 , A61K9/2027 , A61K9/2081 , A61K9/284 , A61K9/2886 , A61K9/5073
摘要： Abuse resistant pharmaceutical formulations are provided that contain one or more abusable drugs and one or more abuse deterrent components. The abuse deterrent component(s) prevent the abusable drug(s) from being removed/extracted to an appreciable extent and/or rate. The abuse deterrent component(s) may be in the form of pellets, beads, beadlets, granules, powders, or the like, and may comprise a core that contains a material that is both hydrophilic and hydrophobic, and optionally a pH-dependent coating.
摘要翻译： 提供了滥用药物制剂，其含有一种或多种可滥用药物和一种或多种滥用威慑成分。 滥用威慑成分可以防止滥用药物以明显的程度和/或率被去除/提取。 滥用威慑组分可以是丸粒，珠粒，珠粒，颗粒，粉末等的形式，并且可以包含含有亲水和疏水的材料的芯，以及任选的pH依赖性涂层 。
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公开(公告)号：USRE42096E1
公开(公告)日：2011-02-01
申请号：US11091011
申请日：2005-03-24
申请人： Beth A. Burnside , Xiaodi Guo , Kimberly Fiske , Richard A. Couch , Rong-Kun Chang , Donald J. Treacy , Charlotte M. McGuiness , Edward M. Rudnic
发明人： Beth A. Burnside , Xiaodi Guo , Kimberly Fiske , Richard A. Couch , Rong-Kun Chang , Donald J. Treacy , Charlotte M. McGuiness , Edward M. Rudnic
IPC分类号： A61K9/16
CPC分类号： A61K9/5026 , A61K9/5047 , A61K9/5078 , A61K31/137
摘要： A multiple pulsed dose drug delivery system for pharmaceutically active amphetamine salts, comprising an immediate-release component and an enteric delayed-release component wherein (1) the enteric release coating has a defined minimum thickness and/or (2) there is a protective layer between the pharmaceutically active amphetamine salt and the enteric release coating and/or (3) there is a protective layer over the enteric release coating. The product can be composed of either one of a number of beads in a dosage form, including either capsule, tablet, or sachet method for administering the beads.
摘要翻译： 一种用于药物活性苯丙胺盐的多脉冲剂量药物递送系统，其包含速释组分和肠溶缓释组分，其中（1）肠释放包衣具有限定的最小厚度和/或（2）存在保护层 在药物活性苯丙胺盐和肠溶释放包衣之间和/或（3）在肠溶释放包衣上有保护层。 产品可以由剂型中的多个珠粒之一组成，包括用于施用珠粒的胶囊，片剂或小袋方法。
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3.发明授权公开(公告)号：US07074417B2
公开(公告)日：2006-07-11
申请号：US10211729
申请日：2002-08-02
CPC分类号： A61K9/2054 , A61K9/1652 , A61K9/2031 , A61K9/2081 , A61K9/5015 , A61K9/5026 , A61K9/5047 , A61K9/5084 , A61K31/7048
摘要： An anti-viral product is comprised of at least three delayed release dosage forms, each of which has a different release profile, with the Cmax for the anti-viral product being reached in less than about twelve hours after initial release of anti-viral from the product.
摘要翻译： 抗病毒产品由至少三种延迟释放剂型组成，每种延迟释放剂型具有不同的释放特征，抗小鼠产品的C max在小于约12小时内达到 最初从产品中释放出抗病毒药物。
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公开(公告)号：US06667057B2
公开(公告)日：2003-12-23
申请号：US10027366
申请日：2001-12-20
IPC分类号： A61K922
CPC分类号： A61K9/2081 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5084 , A61K31/00 , A61K31/4164 , A61K31/43 , A61K31/7048 , A61K45/06 , Y10S514/964 , A61K2300/00
摘要： An antibiotic product, in particular levofloxacin, is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as two or more delayed release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.
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公开(公告)号：US06541014B2
公开(公告)日：2003-04-01
申请号：US09791906
申请日：2001-02-22
IPC分类号： A61K900
CPC分类号： A61K9/2081 , A61K9/4808 , A61K9/5026 , A61K9/5078 , A61K9/5084 , A61K31/7048
摘要： An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as two or more delayed release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.
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公开(公告)号：US06322819B1
公开(公告)日：2001-11-27
申请号：US09176542
申请日：1998-10-21
申请人： Beth A. Burnside , Xiaodi Guo , Kimberly Fiske , Richard A. Couch , Donald J. Treacy , Rong-Kun Chang , Charlotte McGuinness , Edward M. Rudnic
发明人： Beth A. Burnside , Xiaodi Guo , Kimberly Fiske , Richard A. Couch , Donald J. Treacy , Rong-Kun Chang , Charlotte McGuinness , Edward M. Rudnic
IPC分类号： A61K916
CPC分类号： A61K9/5026 , A61K9/5047 , A61K9/5078 , A61K31/137
摘要： A multiple pulsed dose drug delivery system for pharmaceutically active amphetamine salts, comprising an immediate-release component and an enteric delayed-release component wherein (1) the enteric release coating has a defined minimum thickness and/or (2) there is a protective layer between the pharmaceutically active amphetamine salt and the enteric release coating and/or (3) there is a protective layer over the enteric release coating. The product can be composed of either one or a number of beads in a dosage form, including either capsule, tablet, or sachet method for administering the beads.
摘要翻译： 一种用于药物活性苯丙胺盐的多脉冲剂量药物递送系统，其包含速释组分和肠溶缓释组分，其中（1）肠释放包衣具有限定的最小厚度和/或（2）存在保护层 在药物活性苯丙胺盐和肠溶释放包衣之间和/或（3）在肠溶释放包衣上有保护层。 产物可以由剂型中的一种或多种珠组成，包括用于施用珠的胶囊，片剂或小袋方法。
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公开(公告)号：US6110498A
公开(公告)日：2000-08-29
申请号：US954947
申请日：1997-10-22
申请人： Edward M. Rudnic , Beth A. Burnside , Henry H. Flanner , Sandra E. Wassink , Richard A. Couch , Jill E. Pinkett
发明人： Edward M. Rudnic , Beth A. Burnside , Henry H. Flanner , Sandra E. Wassink , Richard A. Couch , Jill E. Pinkett
CPC分类号： A61K9/0004 , Y10S514/96
摘要： An osmotic drug delivery system, preferably in tablet form, which dispenses a therapeutic agent having limited water solubility in solubilized form. The delivery system comprises a core that is free of swellable polymers and comprises nonswelling solubilizing agents and wicking agents. The solubilized therapeutic agent is delivered through a passageway in the semipermeable coating of the tablet.
摘要翻译： 渗透性药物递送系统，优选片剂形式，其分散具有溶解形式的水溶性有限的治疗剂。 递送系统包括不含可溶胀聚合物的芯，并且包含非溶胀增溶剂和芯吸剂。 溶解的治疗剂通过片剂的半透性涂层中的通道递送。
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公开(公告)号：US5262165A
公开(公告)日：1993-11-16
申请号：US828859
申请日：1992-02-04
CPC分类号： A61K9/7053 , A61K31/21 , A61K47/12 , A61K47/22 , A61K9/0014 , A61K9/7061 , A61K9/7069 , Y10S514/946 , Y10S514/947
摘要： A transdermal nitroglycerin patch exhibiting superior nitroglycerin skin penetrating characteristics comprising a percutaneous penetration enhancer is disclosed, wherein the penetration enhancer may be one or more of N-methyl-2-pyrrolidone, oleic acid, oleyl butanediol, linoleic acid, isopropyl linoleate, azone and alcohol. Also disclosed is a transdermal patch design comprising two concentric rings, wherein the concentrations of nitroglycerin and the permeability enhancer are varied.
摘要翻译： 公开了一种表现出优异的硝酸甘油皮肤穿透特性的透皮硝酸甘油片，其包含经皮穿透增强剂，其中渗透促进剂可以是N-甲基-2-吡咯烷酮，油酸，油基丁二醇，亚油酸，亚油酸异丙酯， 醇。 还公开了包括两个同心环的透皮贴剂设计，其中硝酸甘油和渗透性增强剂的浓度是变化的。
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公开(公告)号：US4999189A
公开(公告)日：1991-03-12
申请号：US270311
申请日：1988-11-14
CPC分类号： A61K47/48184 , A61K9/0095 , A61K9/5073 , Y10S514/964
摘要： Stable sustained release wax- and polymer-coated drug-ion exchange resin complexes especially useful in preparing oral suspensions are disclosed.
摘要翻译： 公开了在制备口服悬浮液中特别有用的稳定的持续释放蜡和聚合物涂覆的药物 - 离子交换树脂配合物。
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公开(公告)号：US20130022646A1
公开(公告)日：2013-01-24
申请号：US13442849
申请日：2012-04-09
申请人： Edward M. Rudnic , Michael Vachon , Gary W. Pace
发明人： Edward M. Rudnic , Michael Vachon , Gary W. Pace
IPC分类号： A61K31/485 , A61P25/04 , A61K9/00
CPC分类号： A61K45/06 , A61K9/1635 , A61K9/2077 , A61K9/2081 , A61K9/209 , A61K9/2846 , A61K9/5026 , A61K9/5042 , A61K9/5073 , A61K31/485 , A61K2300/00
摘要： Pharmaceutical formulations containing opioid components that each has a release profile. The components may provide immediate or controlled release of the opioid. The invention is also directed to methods of controlling release of one or more opioid compounds and methods of treating pain.
摘要翻译： 含有阿片样物质成分的药物制剂，各自具有释放特征。 组分可以提供阿片样物质的即时或受控释放。 本发明还涉及控制一种或多种阿片类化合物释放的方法和治疗疼痛的方法。
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