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公开(公告)号:US20060052611A1
公开(公告)日:2006-03-09
申请号:US10539512
申请日:2003-12-16
申请人: Mark Fraley , Robert Garbaccio , Christy Olson , Edward Tasber
发明人: Mark Fraley , Robert Garbaccio , Christy Olson , Edward Tasber
IPC分类号: C07D401/02 , C07D211/70
CPC分类号: C07D401/04 , C07D211/70
摘要: The present invention relates to tetrahydropyridine compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals
摘要翻译: 本发明涉及可用于治疗细胞增殖性疾病,用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的四氢吡啶化合物。 本发明还涉及包含这些化合物的组合物,以及使用它们治疗哺乳动物癌症的方法
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公开(公告)号:US20060105997A1
公开(公告)日:2006-05-18
申请号:US10517559
申请日:2003-06-12
申请人: Kenneth Arrington , Paul Coleman , Christopher Cox , Mark Fraley , Robert Garbaccio , George Hartman , William Hoffman , Edward Tasber
发明人: Kenneth Arrington , Paul Coleman , Christopher Cox , Mark Fraley , Robert Garbaccio , George Hartman , William Hoffman , Edward Tasber
IPC分类号: A61K31/675 , A61K31/4025 , C07D43/02
CPC分类号: C07D401/12 , C07D207/14 , C07D207/20 , C07D207/48 , C07D265/30 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12
摘要: The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译: 本发明涉及可用于治疗细胞增殖性疾病,用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的二氢吡咯化合物。 本发明还涉及包含这些化合物的组合物,以及使用它们治疗哺乳动物癌症的方法。
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