公开(公告)号：US5998151A

公开(公告)日：1999-12-07

申请号：US758034

申请日：1996-11-27

申请人： Patrick G. Johnston ,  Carmen J. Allegra ,  Edwin R. Fisher

发明人： Patrick G. Johnston ,  Carmen J. Allegra ,  Edwin R. Fisher

IPC分类号： C07K16/40 ,  C12N9/12 ,  G01N33/573 ,  G01N33/574 ,  G01N33/53 ,  C07K1/00 ,  C07K16/00

CPC分类号： C12N9/1229 ,  C07K16/40 ,  G01N33/573 ,  G01N33/57484 ,  G01N2800/52

摘要： Methods for determining whether a chemotherapeutic treatment is appropriate for patients afflicted with gastrointestinal cancers, comprising;(a) obtaining a solid tumor tissue sample from the patient;(b) measuring a thymidylate synthase expression level in the tissue sample; and(c) comparing the thymidylate synthase expression level with a group of standard tumor tissue samples, the standards having known thymidylate synthase expression levels and known responses to the chemotherapeutic treatment, to determine if that chemotherapeutic treatment is appropriate for the patient.

摘要翻译： 用于确定化学治疗是否适合于患有胃肠癌的患者的方法，包括： （a）从患者获得实体肿瘤组织样品; （b）测量组织样品中的胸苷酸合酶表达水平; 和（c）将胸苷酸合酶表达水平与一组标准肿瘤组织样品进行比较，所述标准品具有已知的胸苷酸合酶表达水平和对化学治疗处理的已知反应，以确定该化学治疗是否适合于患者。