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公开(公告)号：US20100105882A1
公开(公告)日：2010-04-29
申请号：US12517964
申请日：2007-12-05
CPC分类号： C12N15/62 , C07K14/47 , C07K2319/23 , G01N33/532
摘要： The present invention aims at providing a general-purpose experimental tool which specifically binds to a macromolecular substance that will be a receptor for a specific ligand such as drug, and is applicable throughout various processes to explore the nature of the macromolecular substance. In order to achieve this object, a molecular module has been developed which binds to a target compound and is used for purifying or labeling the target compound, wherein the molecular module has a rod-like spacer substance, an interacting substance that interacts with the target compound, a tag and a labeling substance, the interacting substance being positioned at one end of the rod-like spacer substance, and the tag and the labeling substance being positioned at the other end of the rod-like spacer substance.
摘要翻译： 本发明的目的在于提供一种特异性结合作为特定配体如药物的受体的大分子物质的通用实验工具，并且可用于各种过程以探索大分子物质的性质。 为了实现该目的，开发了一种结合目标化合物并用于纯化或标记目标化合物的分子模块，其中分子模块具有棒状间隔物质，与靶标相互作用的相互作用物质 化合物，标签和标记物质，所述相互作用物质位于所述棒状间隔物质的一端，并且所述标签和所述标记物质位于所述棒状间隔物质的另一端。
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2.发明申请公开(公告)号：US20070253612A1
公开(公告)日：2007-11-01
申请号：US11810632
申请日：2007-06-06
申请人： Eisaku Katayama , Norio Baba , Yoshitaka Kimori
发明人： Eisaku Katayama , Norio Baba , Yoshitaka Kimori
CPC分类号： H01J37/22 , G01N23/046 , G01N2223/419 , H01J2237/221 , H01J2237/2611
摘要： There is provided a three-dimensional image reconstructing apparatus for reconstructing a three-dimensional image of an object. The three-dimensional image reconstructing apparatus includes an image-capturing section that captures a plurality of transmission-type images each of which is represented by densities of different levels, a characteristic region selecting section that selects a plurality of characteristic regions in each of the transmission-type images, a characteristic region distribution calculating section that calculates a spatial distribution of the characteristic regions based on respective positions of the characteristic regions, in each of the transmission-type images, and a three-dimensional image reconstructing section that, when reconstructing the three-dimensional image which shows the three-dimensional structure of the object and in which the densities of different levels are allocated to the whole object by integrating the transmission-type images, allocates the densities of different levels of the transmission-type images to respective positions, in the three-dimensional image, of the characteristic regions based on the spatial distribution of the characteristic regions, so as to reconstruct the three-dimensional image in which a three-dimensional structure in each of the characteristic regions is shown.
摘要翻译： 提供了一种用于重建物体的三维图像的三维图像重建装置。 三维图像重建装置包括：图像拍摄部，其捕获各自以不同等级的浓度表示的多个发送型图像;特征区域选择部，其在所述发送中选择多个特征区域 特征区域分布计算部分，其基于每个发送型图像中的特征区域的各个位置来计算特征区域的空间分布;以及三维图像重建部分，当重建 通过对发送型图像进行积分，显示对象的三维结构，将不同级别的密度分配给整个对象的三维图像，将发送型图像的不同级别的密度分配给各自的 位置，三维图像，c 基于特征区域的空间分布的特征区域，以重建其中示出了每个特征区域中的三维结构的三维图像。
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3.发明授权Image processing apparatus, image processing method, computer readable medium, and computer program thereof 有权图像处理装置，图像处理方法，计算机可读介质及其计算机程序公开(公告)号：US07639865B2
公开(公告)日：2009-12-29
申请号：US10461920
申请日：2003-06-13
申请人： Eisaku Katayama , Norio Baba
发明人： Eisaku Katayama , Norio Baba
IPC分类号： G06K9/00
CPC分类号： G01N23/046 , G01N2223/419 , G06T7/55 , G06T15/00
摘要： It is an object of the present invention to acquire 3-dimensional image data that correctly express a structural configuration of the subject by processing the projected image data obtained by projecting the subject toward the plural angles . A shape computing unit 260 calculates shape data which represent a outline of the subject, using a plurality of 1st image data of the subject obtained by projecting the subject toward the plural angles. A distributing unit 220 generates gray-scale density-distributions by spreading and distributing densities shown in gray-scale image of the subject respectively within angles along which said gray-scale image was captured. A second integrating unit 240 generates 3-dimensional gray-scale data, which expresses the subject with the 3-dimensional image data, by integrating a plurality of said gray-scale density-distributions generated from a plurality of gray-scale image captured from a plurality of angles. A first integrating unit 280 integrates the shape data and 3-dimensional gray-scale image. A data processing unit 300 generates 3-dimensional image data by extracting only density that exists in perimeter of a shape that the shape data represent, from the 3-dimensional gray-scale data.
摘要翻译： 本发明的目的是通过处理通过将被摄体投影到多个角度而获得的投影图像数据来获取正确表达被摄体的结构构造的3维图像数据。 形状计算单元260使用通过将对象投影到多个角度而获得的被摄体的多个第一图像数据来计算表示被摄体的轮廓的形状数据。 分配单元220通过在被摄体的灰度级图像的角度内分别扩散和分布被摄物体的灰度图像中所示的密度来生成灰度密度分布。 第二积分单元240通过对从多个灰度图像中捕获的多个灰度级图像进行积分而生成多个所述灰度密度分布，生成表示具有3维图像数据的被摄体的三维灰度数据 多个角度 第一积分单元280对形状数据和三维灰度图像进行积分。 数据处理单元300通过从三维灰度数据中仅提取存在于形状数据表示的形状的周边的密度来生成三维图像数据。
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4.发明授权公开(公告)号：US07379582B2
公开(公告)日：2008-05-27
申请号：US10660464
申请日：2003-09-11
申请人： Eisaku Katayama , Norio Baba
发明人： Eisaku Katayama , Norio Baba
IPC分类号： G06K9/00
CPC分类号： G06K9/00134 , G06T7/0002 , G06T7/001 , G06T7/564 , G06T7/97 , G06T2200/04
摘要： A projection image data captured from a plurality of angles is processed, and a three-dimensional image data accurately indicating a three dimensional structure for an object is obtained. A shape computing unit 260 computes shape data indicating an outline of a subject using a plurality of first image data of the subject captured from a plurality of angles. A distributing unit 220 generates a gray-scale density-distribution by extending and distributing density indicated in a gray-scale image of the subject acquired by a projection image capturing apparatus to an angle at which the gray-scale image is captured. The second integrating unit 240 generates a three-dimensional gray-scale data indicating the subject with three-dimensional image data by integrating a plurality of gray-scale images acquired from a plurality of angles and a plurality of gray-scale density-distribution. The first integrating unit 280 integrates the three-dimensional gray-scale image and shape data. The data processing unit 300 generates the three-dimensional image data by extracting only the gray-scale data which exists in the circumference of the shape indicated in the shape data from the three-dimensional gray-scale data.
摘要翻译： 处理从多个角度拍摄的投影图像数据，并且获得准确地指示对象的三维结构的三维图像数据。 形状计算单元260使用从多个角度捕获的对象的多个第一图像数据来计算指示对象的轮廓的形状数据。 分配单元220通过将由投影图像捕获装置获取的被摄体的灰度图像中指示的浓度扩展并分布到捕获灰度图像的角度来生成灰度密度分布。 第二积分单元240通过对从多个角度获得的多个灰度图像和多个灰度密度分布进行积分，生成表示具有三维图像数据的对象的三维灰度数据。 第一积分单元280对三维灰度图像和形状数据进行积分。 数据处理单元300通过从三维灰度数据中仅提取存在于形状数据中指示的形状的圆周中的灰度数据来生成三维图像数据。
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公开(公告)号：US08304520B2
公开(公告)日：2012-11-06
申请号：US12517964
申请日：2007-12-05
CPC分类号： C12N15/62 , C07K14/47 , C07K2319/23 , G01N33/532
摘要： The present invention aims at providing a general-purpose experimental tool which specifically binds to a macromolecular substance that will be a receptor for a specific ligand such as drug, and is applicable throughout various processes to explore the nature of the macromolecular substance. In order to achieve this object, a molecular module has been developed which binds to a target compound and is used for purifying or labeling the target compound, wherein the molecular module has a rod-like spacer substance, an interacting substance that interacts with the target compound, a tag and a labeling substance, the interacting substance being positioned at one end of the rod-like spacer substance, and the tag and the labeling substance being positioned at the other end of the rod-like spacer substance.
摘要翻译： 本发明的目的在于提供一种特异性结合作为特定配体如药物的受体的大分子物质的通用实验工具，并且可用于各种过程以探索大分子物质的性质。 为了实现该目的，开发了一种结合目标化合物并用于纯化或标记目标化合物的分子模块，其中分子模块具有棒状间隔物质，与靶标相互作用的相互作用物质 化合物，标签和标记物质，所述相互作用物质位于所述棒状间隔物质的一端，并且所述标签和所述标记物质位于所述棒状间隔物质的另一端。
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6.发明授权公开(公告)号：US07853069B2
公开(公告)日：2010-12-14
申请号：US11810632
申请日：2007-06-06
申请人： Eisaku Katayama , Norio Baba , Yoshitaka Kimori
发明人： Eisaku Katayama , Norio Baba , Yoshitaka Kimori
IPC分类号： G06K9/00
CPC分类号： H01J37/22 , G01N23/046 , G01N2223/419 , H01J2237/221 , H01J2237/2611
摘要： There is provided a three-dimensional image reconstructing apparatus for reconstructing a three-dimensional image of an object. The three-dimensional image reconstructing apparatus includes an image-capturing section that captures a plurality of transmission-type images each of which is represented by densities of different levels, a characteristic region selecting section that selects a plurality of characteristic regions in each of the transmission-type images, a characteristic region distribution calculating section that calculates a spatial distribution of the characteristic regions based on respective positions of the characteristic regions, in each of the transmission-type images, and a three-dimensional image reconstructing section that, when reconstructing the three-dimensional image which shows the three-dimensional structure of the object and in which the densities of different levels are allocated to the whole object by integrating the transmission-type images, allocates the densities of different levels of the transmission-type images to respective positions, in the three-dimensional image, of the characteristic regions based on the spatial distribution of the characteristic regions, so as to reconstruct the three-dimensional image in which a three-dimensional structure in each of the characteristic regions is shown.
摘要翻译： 提供了一种用于重建物体的三维图像的三维图像重建装置。 三维图像重建装置包括：图像拍摄部，其捕获各自以不同等级的浓度表示的多个发送型图像;特征区域选择部，其在所述发送中选择多个特征区域 特征区域分布计算部分，其基于每个发送型图像中的特征区域的各个位置来计算特征区域的空间分布;以及三维图像重建部分，当重建 通过对发送型图像进行积分，显示对象的三维结构，将不同级别的密度分配给整个对象的三维图像，将发送型图像的不同级别的密度分配给各自的 位置，三维图像，c 基于特征区域的空间分布的特征区域，以重建其中示出了每个特征区域中的三维结构的三维图像。
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7.发明授权公开(公告)号：US06828555B2
公开(公告)日：2004-12-07
申请号：US10612820
申请日：2003-07-02
申请人： Eisaku Katayama , Norio Baba
发明人： Eisaku Katayama , Norio Baba
IPC分类号： H01J3726
CPC分类号： H01J37/26 , H01J37/222 , H01J2237/22 , H01J2237/2611 , H01J2237/2617
摘要： Verification of properness of a modeling theory of an uncrystallized substance or an image processing method is made easy. There includes: a first displaying unit 120 for rotationally displaying an simulated three-dimensionally shaded model image, which is a shaded image of the three-dimensional reconstruction image; and a second displaying unit 140 for displaying the three-dimensional image of the substance acquired by experimental structural analysis, which synchronously rotates with the simulated three-dimensionally shaded model image.
摘要翻译： 验证未结晶物质的建模理论的正确性或图像处理方法是容易的。 包括：第一显示单元120，用于旋转地显示作为三维重建图像的阴影图像的模拟三维阴影模型图像; 以及第二显示单元140，用于显示通过实验结构分析获得的物质的三维图像，其与模拟的三维阴影模型图像同步旋转。
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